Insulin Metabolism is Altered in Migraineurs: A New Pathogenic Mechanism for Migraine?

Cavestro, Cinzia; Rosatello, Annalisa; Micca, Gianmatteo; Ravotto, Marisa; Marino, Maria; Asteggiano, Giovanni; Beghi, Ettore

doi:10.1111/j.1526-4610.2007.00719.x

Cited by 89 publications

(78 citation statements)

References 29 publications

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“…Lastly, I/C ratio was significantly different between the three groups with I/C ratio on average lower in male migraineurs and higher in female migraineurs. Recent work comparing glucose and insulin concentrations in migraineurs, headache patients, and non-migraine/headache controls has confirmed that while an elevation in glucose may be associated with headaches in general, an elevated insulin level is specific to migraineurs [7]. In the present study we noted a non-significant trend for a higher plasma glucose level following a sucrose load in migraineurs with the level of plasma glucose becoming significantly elevated in migraineurs at 150-min.…”

Section: Discussionsupporting

confidence: 71%

Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences

Kokavec

2015

Physiology & Behavior

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Section: Discussionsupporting

confidence: 71%

Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences

Kokavec

2015

Physiology & Behavior

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“…Cavestro [32] compared glucose and insulin concentrations in 84 migraineurs, 25 headache patients, and 26 nonmigraine/headache controls and confirmed that an elevation in glucose may be associated with headaches in general, but elevated insulin level seems to be specifically associated with migraine attacks.…”

Section: Fasting Glucose Metabolism and Migrainementioning

confidence: 99%

Food as trigger and aggravating factor of migraine

Finocchi

Sivori

2012

Neurol Sci

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A relevant proportion of patients say that their migraine attacks may be precipitated by dietary items, the percentage of patients reporting foods as trigger ranging in different study from 12 to 60 %. Fasting, alcohol, chocolate and cheese are the dietary precipitating factors more frequently reported. The finding that diet-sensitive migraineurs are usually sensitive to several and different foods, lead to the hypothesis of antigenic similarities between these disparate foods or common chemical constituents, but a clear scientific explanation of the mechanisms implicated in the development of migraine attacks supposedly precipitated by food is still lacking. The possibility that the elimination diets based on the hypothesis of food hypersensivity IgE or IgG-mediated improve migraine has been explored in different studies but the results are inconclusive. Fasting as trigger for migraine is frequently reported. Some migraineurs show reactive hypoglycaemia due to diet-induced hyperinsulinism. In conclusion, identification of environmental factors (including dietary factors) that consistently trigger migraine in some subjects may be helpful to reduce attacks frequency. The biological mechanism by means of triggers in general and food in particular precipitate migraine attacks remains obscure.

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“…Current studies by Rainero et al (1) and Cavestro et al (2) show that insulin sensitivity is impaired in migraine patients, which suggests a role for insulin resistance in the comorbidity of migraine and vascular diseases. Impaired insulin sensitivity in migraine patients is of particular interest, as insulin resistance has emerged as a risk factor for coronary artery disease, hypertension and stroke (3)(4)(5).…”

Section: Introductionmentioning

confidence: 97%

Hyperinsulinaemia in migraineurs is associated with nitric oxide stress

Hj¹,

Bernecker²,

Pailer³

et al. 2009

Cephalalgia

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There is growing evidence that alterations in the insulin and glucose metabolism may be involved in the pathogenesis of migraine. Nitric oxide (NO) stress has been associated with migraine. However, the role of NO on the insulin and glucose metabolism in migraineurs has remained elusive to date. The aim of the present study was to investigate the insulin and glucose metabolism in migraineurs and to determine possible interactions with the NO pathway. One hundred and twenty non-obese probands participated in this study, including 48 migraineurs and 72 healthy volunteers. Various parameters of the NO pathway, glucose metabolism as well as body measurement parameters were determined. We found a highly significantly increased insulin and Homeostasis Model Assessment (HOMA)-index in migraine patients, whereas fasting glucose was decreased. Logistic regression revealed an odds ratio of 5.67 for migraine, when comparing the lowest with the highest quartile of HOMA. Multivariate analysis showed that HOMA, waist-to-length ratio and nitrite as parameters of NO stress were highly significantly correlated. We show here that hyperinsulinaemia is associated with migraine and, furthermore, is correlated with increased NO stress. These findings represent a new pathophysiological mechanism that may be of clinical relevance.

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Insulin Metabolism is Altered in Migraineurs: A New Pathogenic Mechanism for Migraine?

Cited by 89 publications

References 29 publications

Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences

Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences

Food as trigger and aggravating factor of migraine

Hyperinsulinaemia in migraineurs is associated with nitric oxide stress

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