Insulin-like growth factor (IGF)-binding proteins in serum--do they have additional roles besides modulating the endocrine IGF actions?

Mohan, Subburaman; Baylink, D J; Pettis, Jessica

doi:10.1210/jcem.81.11.8923818

Cited by 77 publications

(42 citation statements)

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“…Insulin/IGF1-signaling pathway has long been known to modulate the regulation of thyroid gene expression and might be considered as additional important factors in thyrocyte proliferation and differentiation (35,36). TSH is a wellknown mitogen in the presence of insulin in cell cultures, and it also suppresses apoptotic cell death in response to various stimuli (37).…”

Section: Thyroid Nodulementioning

confidence: 99%

Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area

Ayturk

Gürsoy

Kut

et al. 2009

European Journal of Endocrinology

182

146

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Objective: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities with insulin resistance (IR) as a major component. It has been recently questioned whether MetS and its related components are associated with functional and morphological alterations of the thyroid gland. The aim of our study is to examine thyroid volume and nodule prevalence in a case-control study of patients with MetS in a mild-to-moderate iodine-deficient area. Design: Two hundred and seventy-eight patients with MetS were randomly matched for age, gender, and smoking habits with 261 subjects without MetS. Serum TSH, free tri-iodothyronine and thyroxine, and the level of IR, which was estimated by the homeostasis model assessment for IR, as well as other MetS parameters were evaluated. Thyroid ultrasonography was performed in all subjects. All subjects with thyroid nodules O1 cm were offered to undergo thyroid fine needle aspiration biopsy. Results: TSH was significantly positively correlated with the presence of MetS diagnosis. There was no association between free thyroid hormone levels and MetS and its related components. Mean thyroid volume was significantly higher in patients with MetS than in controls (17.5G5.5 vs 12.2G4.2 ml, P!0.0001). Also the percentage of patients with thyroid nodules was significantly higher in patients with MetS (50.4 vs 14.6%, P!0.0001). Subjects were also divided into two groups according to the presence of IR. The group of subjects with IR had increased thyroid volume and nodule formation. The odds ratio for the development of thyroid nodule in the presence of IR was 3.2. TSH as well as all MetS components were found to be independent predictors for thyroid volume increase. IR but not TSH was found to be correlated with thyroid nodule formation. Thyroid cancer was diagnosed in 3 out of 38 patients with MetS who agreed to have a biopsy (7.9%). None of the subjects in the control group was diagnosed to have thyroid cancer. Conclusions:The results suggest that patients with MetS have significantly increased thyroid volume and nodule prevalence. Multivariate regression analysis model demonstrated that the presence of IR contributed substantially to this increased risk. Our data provide the first evidence that IR is an independent risk factor for nodule formation in an iodine-deficient environment.

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Section: Thyroid Nodulementioning

confidence: 99%

Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area

Ayturk

Gürsoy

Kut

et al. 2009

European Journal of Endocrinology

182

146

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show abstract

“…In experimental systems the addition of IGFBPs generally inhibits the activities of IGFs, presumably by sequestering a high proportion of the free growth factor 23 . In this way IGFBPs act as regulators of IGF action and increase their half-life.…”

Section: Igf-1 Andmentioning

confidence: 99%

The GH–IGF-I axis and breast cancer

Laban

Bustin

Jenkins

2003

Trends in Endocrinology & Metabolism

109

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“…It has also been suggested recently that the IGFBP themselves may bind to cell surfaces and have effects via IGF-independent mechanisms (see Mohan & Baylink, 1996). At least five of the IGFBP appear to be produced by muscle cells in culture, with IGFBP-2, -3, -4, -5 and -6 being found at varying levels in different muscle cell types.…”

Section: Autocrine Expression Of Growth Factors and Their Receptorsmentioning

confidence: 99%

Nutritional and hormonal control of skeletal-muscle cell growth and differentiation

et al. 1998

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Insulin-like growth factor (IGF)-binding proteins in serum--do they have additional roles besides modulating the endocrine IGF actions?

Cited by 77 publications

References 0 publications

Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area

Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area

The GH–IGF-I axis and breast cancer

Nutritional and hormonal control of skeletal-muscle cell growth and differentiation

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