Nutritional and hormonal control of skeletal-muscle cell growth and differentiation

Brameld, John M.; Buttery, P. J.; Dawson, J. M.; Harper, J.M.M.

doi:10.1079/pns19980033

Cited by 67 publications

(58 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Muscle cell proliferation has been found to be dependent on maternal nutrition and the supply of maternal nutrients in pigs (Robinson 1969;Buitrago et al 1974;Powell and Aberle 1981;Dwyer et al 1994) and other species (Glore and Layman 1983;Dwyer et al 1995). Nevertheless, it remains unclear whether higher nutrient availability affected cell proliferation directly or indirectly via hormones/growth factors controlled by nutrient intake (see Brameld et al 1998). Direct effects of increased growth hormone and IGF-I in maternal plasma (Kanitz et al 1995) on the embryos can be largely excluded, because there is no physiologically important transfer of peptide hormones across the placenta (Milner and Hill 1987;Fholenhag et al 1994).…”

Section: Discussionmentioning

confidence: 98%

Maternal treatment with somatotropin during early gestation affects basic events of myogenesis in pigs

et al. 2001

View full text Add to dashboard Cite

The effects of maternal treatment with somatotropin during early gestation on fetal muscle development were determined. Crossbred gilts received daily injections of either 3 ml of a placebo ( n=31) or of 6 mg porcine somatotropin ( n=31) from day (d) 10 to 27 of gestation and samples were collected from d 28 embryos, d 37 and 62 fetuses, and from neonates. Administration of somatotropin increased the total number of fibres (primary and secondary fibres) in neonatal semitendinosus muscle of middle- and low-weight littermates, whilst no increase was observed in psoas major muscle. Somatotropin induced increases in muscular protein concentration, creatine kinase activity, muscle fibre girth, as well as type II to type I fibre conversion which revealed an advanced degree of differentiation at birth. Treatment effects on prenatal development preceded these changes. Increased DNA concentrations at d 28 of gestation indicate stimulation of cellular proliferation during the embryonic stages. Thereafter, the withdrawal of somatotropin caused a transient delay of differentiation as indicated by lower protein concentrations and creatine kinase activity compared with controls at d 37 of gestation. This was compensated again at d 62, and the number of semitendinosus primary fibres was increased in middle-weight fetuses, whereas secondary or total fibre number did not yet differ. However, enhanced expression of Myf5 and MyoD indicates higher numbers of initially determined, proliferating myoblasts that may have contributed to increased formation of secondary fibres. In conclusion, maternal somatotropin is an influential factor in early pregnancy capable of affecting the basic events of myogenesis.

show abstract

Section: Discussionmentioning

confidence: 98%

Maternal treatment with somatotropin during early gestation affects basic events of myogenesis in pigs

et al. 2001

View full text Add to dashboard Cite

show abstract

“…In contrast, there are several studies (Louey et al 2005;De Blasio et al 2007;Wallace et al 2011b;Hancock et al 2012) suggesting that low birthweight, often as a consequence of placental insufficiency, is associated with increased adiposity in both young and old offspring. Studies in runted pigs (IUGR) show not only fewer muscle fibres in later life compared with their high birthweight littermates, but also increased adipose tissue depot weights and reduced postnatal growth rates (see Brameld et al 2003). Increased adiposity in runted pigs is thought to be due to increased numbers of small-diameter adipocytes in the various fat depots.…”

Section: Body Fat or Adipositymentioning

confidence: 99%

Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

View full text Add to dashboard Cite

Abstract. The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

show abstract

“…The effect of reducing maternal nutrient intake on fetal development depends upon the timing, duration and severity of the nutritional insult (see Robinson et al 1999) and may be mediated through alterations in the fetal insulin-like growth factor (IGF) axis (Bauer et al 1995). The insulinlike growth factors (IGF-I and IGF-II) are mitogenic peptides that have a fundamental role in regulating fetal growth due to their ability to stimulate proliferation and differentiation of a number of cell types (Cohick & Clemmons 1993, Brameld et al 1998. They are expressed by most cell types, with the highest expression of IGF-II occurring during fetal development (Han et al 1988).…”

Section: Introductionmentioning

confidence: 99%

Maternal nutrition alters the expression of insulin-like growth factors in fetal sheep liver and skeletal muscle

Brameld¹,

Mostyn²,

Dandrea³

et al. 2000

Journal of Endocrinology

109

View full text Add to dashboard Cite

We investigated the influence of maternal dietary restriction between days 28 and 80 of gestation followed by re-feeding to the intake of well-fed ewes up to 140 days of gestation (term is 147 days) in sheep, on expression of mRNA for insulin-like growth factor (IGF)-I, IGF-II and growth hormone receptor (GHR) in fetal liver and skeletal muscle. Singleton bearing ewes either consumed 3·2-3·8 MJ/day of metabolisable energy (ME) (i.e. nutrient restricted -approximately 60% of ME requirements, taking into account requirements for both ewe maintenance and growth of the conceptus) or 8·7-9·9 MJ/day (i.e. well fed -approximately 150% of ME requirements) between days 28 and 80 of gestation. All ewes were then well fed (150% of ME requirements)

show abstract

Nutritional and hormonal control of skeletal-muscle cell growth and differentiation

Cited by 67 publications

References 110 publications

Maternal treatment with somatotropin during early gestation affects basic events of myogenesis in pigs

Maternal treatment with somatotropin during early gestation affects basic events of myogenesis in pigs

Epigenetics and developmental programming of welfare and production traits in farm animals

Maternal nutrition alters the expression of insulin-like growth factors in fetal sheep liver and skeletal muscle

Contact Info

Product

Resources

About