Insulin-like Growth Factor I—Releasing Alginate-Tricalciumphosphate Composites for Bone Regeneration

Abstract

A prototype in situ-hardening composite system for conformal filling of bone defects supporting osteoblastic activity for further clinical testing in relevant fracture models was developed and characterized.

Three‐dimensional fibrous PLGA/HAp composite scaffold for BMP‐2 delivery

“…6) obtained from this experiment is consistent with the in vitro release profiles of many studies of bone engineering (Hedberg et al, 2002;Jansen et al, 2005;Luginbuehl et al, 2005;Ruhe et al, 2004), but some differences should be emphasized after introducing HAp. Generally, there is a higher percentage of BMP-2 released when more HAp nanoparticles were added.…”

Adipose mesenchymal stem cells in the field of bone tissue engineering

“…The introduction of specific biomolecules has been shown in animal models to enhance the union of nonunion type (a fracture that does not heal by itself after several months) bone fractures [32] . Many growth factors that have been used in bone repair with some degree of success include mitogens such as platelet-derived growth factors, metabolic regulators such as insulin-like growth factors, angiogenic proteins such as basic fibroblast growth factors, and morphogens such as bone morphogenetic proteins (BMPs) [35][36][37][38][39] . BMPs, which are members of the transforming growth factor beta (TGF-β) superfamily, have been the most extensively studied, as they are potent osteoinductive factors that induce the mitogenesis and differentiation of mesenchymal stem cells and other osteoprogenitors [35,11] .…”

Bioengineering Approaches to Controlled Protein Delivery

“…For example, in cartilage-engineering applications, one group incorporated transforming growth factor ␤1 in gelatin microparticles into an oligo(poly(ethylene glycol) fumarate) gel (44), while investigators who delivered it using PLGA microparticles in a PEG-based hydrogel (45) obtained different release profiles. Other examples of this approach include use in bone regeneration, where insulin-like growth factor I encapsulated in PLGA microparticles was placed into an alginate-tricalciumphosphate hydrogels (46) and delivery of VEGF from alginate microparticles incorporated into collagen/fibronectin hydrogels for new vessel formation (data not published).…”