Insulin-like growth factor binding protein (IGFBP)-mediated hair cell survival on the mouse utricle exposed to neomycin: the roles of IGFBP-4 and IGFBP-5

Park, Ji Yeong; Park, Taesung; Shin, Dong Hoon; Oh, Seung Ha

doi:10.1080/03655230701624822

Cited by 11 publications

(2 citation statements)

References 32 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, we examined changes in the expression levels of proteins involved in hair growth. Kim et al (2013) found that VEGF and IGF-1 expression levels were associated with hair growth and that IGF-I promotes hair growth by activating cells at the hair follicle, prolonging the anagen phase of the hair growth cycle ( Park et al, 2007 ; Angunsri et al, 2011 ). VEGF regulates hair follicle stem cell development and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Minoxidil delivered via a stem cell membrane delivery controlled release system promotes hair growth in C57BL/6J mice

Song,

Pan,

Jin

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Objective: Umbilical cord-derived mesenchymal stem cell membrane-loaded minoxidil (MXD) nanoparticles (STCM-MXD-NPs) were prepared to investigate their effects on hair growth in C57BL/6J mice.Methods: STCM-MXD-NPs were obtained by freeze-thawing and differential centrifugation, and their effects on hair growth were evaluated using C57BL/6J mice. The mRNA and protein expression levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) were detected by real-time polymerase chain reaction and enzyme-linked immunosorbent assays, respectively. Protein expression levels of marker of proliferation Ki-67 (MKI67) and β-catenin (CTNNB) in skin tissue were detected by immunohistochemistry.Results: STCM-MXD-NPs improved MXD solubility. They released the drug slowly, increasing its transdermal properties, accumulation in the skin, and content in the hair bulb tissues with a better efficacy than that of ordinary MXD. Moreover, STCM-MXD-NPs significantly upregulated the mRNA and protein levels of VEGF and IGF-1 and promoted the protein expression of MKI67 and CTNNB in mouse skin tissues, promoting mouse hair growth.Conclusion: Stem cell membrane-loaded MXD nanoparticles with slow-release properties increased MXD accumulation in the skin by improving its transdermal properties, increasing VEGF, IGF-1, MKI67, and CTNNB expression levels and promoting hair growth in C57BL/6J mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Minoxidil delivered via a stem cell membrane delivery controlled release system promotes hair growth in C57BL/6J mice

Song,

Pan,

Jin

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Treatment with IGF-1 as well as acidic fibroblast growth factor, epidermal growth factor, and transforming growth factors β1 prevented the loss of outer HCs, suggesting the survival effect of IGF-1 on mature mammalian outer HCs (Malgrange et al, 2002). The survival effect of IGF-1 against aminoglycoside-induced severe HC loss was observed in explant cultures of postnatal mammalian utricle (Park et al, 2007; Angunsri et al, 2011) and in vivo vestibular systems of mature guinea pigs (Kopke et al, 2001). In the case of the in vivo experiments, the perilymph of the mature guinea pig inner ear was infused with mixture of transforming growth factor α, IGF-1, and retinoic acid after injury induced by aminoglycoside, and functional as well as morphological recovery of HCs was observed (Kopke et al, 2001).…”

Section: Igf-1 and The Inner Earmentioning

confidence: 99%

Application of insulin-like growth factor-1 in the treatment of inner ear disorders

2014

View full text Add to dashboard Cite

Sensorineural hearing loss (SNHL) is considered an intractable disease, given that hair and supporting cells (HCs and SCs) of the postnatal mammalian cochlea are unable to regenerate. However, with progress in regenerative medicine in the 21st century, several innovative approaches for achieving regeneration of inner ear HCs and SCs have become available. These methods include stem cell transplantation, overexpression of specific genes, and treatment with growth factors. Insulin-like growth factor-1 (IGF-1) is one of the growth factors that are involved in the development of the inner ear. Treatment with IGF-1 maintains HC numbers in the postnatal mammalian cochlea after various types of HC injuries, with activation of two major pathways downstream of IGF-1 signaling. In the aminoglycoside-treated neonatal mouse cochlear explant culture, promotion of the cell-cycle in SCs as well as inhibition of HC apoptosis was observed in the IGF-1-treated group. Activation of downstream molecules was observed in SCs and, in turn, SCs contribute to the maintenance of HC numbers. Using comprehensive analysis of the gene expression, the candidate effector molecules of the IGF-1 signaling pathway in the protection of HCs were identified as Netrin1 and Gap43. Based on these studies, a clinical trial has sought to investigate the effects of IGF-1 on SNHL. Sudden SNHL (SSHL) that was refractory to systemic steroids was treated with IGF-1 in a gelatin hydrogel and the outcome was compared with a historical control of hyperbaric oxygen therapy. The proportion of patients showing hearing improvement was significantly higher in the IGF-1-treatment group at 24 weeks after treatment than in the control group. A randomized clinical trial is ongoing to compare the effect of IGF-1 treatment with that of intra-tympanic steroids for SSHL that is refractory to systemic steroids.

show abstract

Progress in protecting vestibular hair cells

Jiang

Zheng

2021

Arch Toxicol

View full text Add to dashboard Cite

Vestibular hair cells are mechanosensory receptors that are capable of detecting changes in head position and thereby allow animals to maintain their posture and coordinate their movement. Vestibular hair cells are susceptible to ototoxic drugs, aging, and genetic factors that can lead to permanent vestibular dysfunction. Vestibular dysfunction mainly results from the injury of hair cells, which are located in the vestibular sensory epithelium. This review summarizes the mechanisms of different factors causing vestibular hair cell damage and therapeutic strategies to protect vestibular hair cells.

show abstract

Insulin-like growth factor binding protein (IGFBP)-mediated hair cell survival on the mouse utricle exposed to neomycin: the roles of IGFBP-4 and IGFBP-5

Cited by 11 publications

References 32 publications

Minoxidil delivered via a stem cell membrane delivery controlled release system promotes hair growth in C57BL/6J mice

Minoxidil delivered via a stem cell membrane delivery controlled release system promotes hair growth in C57BL/6J mice

Application of insulin-like growth factor-1 in the treatment of inner ear disorders

Progress in protecting vestibular hair cells

Contact Info

Product

Resources

About