Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis

Conese, Massimo; D’Oria, Susanna; Castellani, Stefano; Trotta, Rosa; Montemurro, P.; Liso, Arcangelo

doi:10.1007/s00011-017-1107-6

Cited by 13 publications

(13 citation statements)

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“…78 We recently investigated whether IGFBP-6 could have any effect on neutrophils' functions as diverse ROS production, degranulation and chemotaxis. 23 IGFBP-6 induced a significant increase in ROS production in neutrophils obtained from healthy donors at all the concentrations tested as compared to untreated controls, with a peak obtained at 1 lg/mL. In relation to degranulation, IGFBP-6 increased significantly MPO levels but did not modify MMP-9 levels as compared to controls.…”

Section: Inflammatory Response An D Inflammatory Disordersmentioning

confidence: 80%

“…Therefore, we explored in our recent publications21, 22, 23 whether recombinant IGFBP‐6 could be part of a comprehensive working model, amenable to experimental validation, of the possible mechanism driving the physical thermal input into a physiological adaptation in MoDCs.…”

Section: Hyperthermia Induces Specific Genetic and Metabolic Reprogramentioning

confidence: 99%

“…At the mucosal level, this multi‐step process leads to migration across the endothelium, the extracellular matrix and the epithelium because of a chemoattractant gradient 78. We recently investigated whether IGFBP‐6 could have any effect on neutrophils’ functions as diverse ROS production, degranulation and chemotaxis 23. IGFBP‐6 induced a significant increase in ROS production in neutrophils obtained from healthy donors at all the concentrations tested as compared to untreated controls, with a peak obtained at 1 μg/mL.…”

Section: Igfbp‐6 New Role In the Inflammatory Response And Inflammatomentioning

confidence: 99%

“…In our hands, IGFBP-6 was in fact the only specifically up-regulated under hyperthermic conditions by MoDCs. 21 Therefore, we explored in our recent publications [21][22][23]…”

Section: Hyperthermia Induce S Specific Genetic and Metabolic Repromentioning

confidence: 99%

“…Moreover, more recently other functions of IGFBP-6 related to the immune system have been discovered (Figure 2), as we found that IGFBP-6 in vitro acts as a chemoattractant towards neutrophils, monocytes and T cells, but clearly not B cells. 21,23 As hyperthermia could induce an increased expression of IGFBP-6 by at the level of dendritic cells (DCs), as well as their metabolic reprogramming, we are currently testing the ability of IGFBP-6 to induce metabolic reprogramming in DCs. The implications of all these findings for cancer biology and pathogenesis of inflammatory disorders are further discussed below.…”

Section: Nuclear Actions Of Igfbp-6mentioning

confidence: 99%

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From fever to immunity: A new role for IGFBP‐6?

Liso

Capitanio

Gerli

et al. 2018

J Cellular Molecular Medi

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Fever is a fundamental response to infection and a hallmark of inflammatory disease, which has been conserved and shaped through millions of years of natural selection. Although fever is able to stimulate both innate and adaptive immune responses, the very nature of all the molecular thermosensors, the timing and the detailed mechanisms translating a physical trigger into a fundamental biological response are incompletely understood. Here we discuss the consequence of hyperthermic stress in dendritic cells (DCs), and how the sole physical input is sensed as an alert stimulus triggering a complex transition in a very narrow temporal window. Importantly, we review recent findings demonstrating the significant and specific changes discovered in gene expression and in the metabolic phenotype associated with hyperthermia in DCs. Furthermore, we discuss the results that support a model based on a thermally induced autocrine signalling, which rewires and sets a metabolism checkpoint linked to immune activation of dendritic cells. Importantly, in this context, we highlight the novel regulatory functions discovered for IGFBP‐6 protein: induction of chemotaxis; capacity to increase oxidative burst and degranulation of neutrophils, ability to induce metabolic changes in DCs. Finally, we discuss the role of IGFBP‐6 in autoimmune disease and how novel mechanistic insights could lead to exploit thermal stress‐related mechanisms in the context of cancer therapy.

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Section: Inflammatory Response An D Inflammatory Disordersmentioning

confidence: 80%

Section: Hyperthermia Induces Specific Genetic and Metabolic Reprogramentioning

confidence: 99%

Section: Igfbp‐6 New Role In the Inflammatory Response And Inflammatomentioning

confidence: 99%

“…In our hands, IGFBP-6 was in fact the only specifically up-regulated under hyperthermic conditions by MoDCs. 21 Therefore, we explored in our recent publications [21][22][23]…”

Section: Hyperthermia Induce S Specific Genetic and Metabolic Repromentioning

confidence: 99%

Section: Nuclear Actions Of Igfbp-6mentioning

confidence: 99%

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