Insulin‐like growth factor‐1 is inversely associated with liver fibrotic markers in patients with type 2 diabetes mellitus

Abstract

Aims/Introduction Insulin‐like growth factor‐1 (IGF‐1) regulates mitochondrial function, oxidative stress, inflammation, stellate cells and insulin sensitivity in the liver, and it might be associated with liver fibrosis from non‐alcoholic steatohepatitis. In contrast, type 2 diabetes mellitus is closely associated with the progression from non‐alcoholic fatty liver to non‐alcoholic steatohepatitis and cirrhosis, so careful evaluation of liver fibrosis is required for patients with type 2 diabetes mellitus. Therefore, we examined the relationship between IGF‐1 and liver fibrosis markers in type 2 diabetes patients without obvious alcoholic consumption and determined whether IGF‐1 is associated with fibrosis of non‐alcoholic fatty liver disease. Materials and Methods We selected 415 patients with type 2 diabetes without obvious alcohol consumption, who were admitted to Uwajima City Hospital between May 2013 and December 2016. We collected and analyzed clinical data to determine correlations between IGF‐1 or IGF‐1 standard deviation score and fibrosis‐4 index or 7S domain of type IV collagen. Results Multiple linear regression analysis showed that the fibrosis‐4 index was inversely correlated with IGF‐1 and IGF‐1 standard deviation score. Furthermore, the 7S domain of type IV collagen was also inversely correlated with IGF‐1 and IGF‐1 standard deviation score. Conclusions IGF‐1 was inversely correlated with liver fibrosis markers in type 2 diabetes mellitus patients without obvious alcoholic consumption. Measuring serum IGF‐1 levels might help clinicians to identify type 2 diabetes mellitus patients with advanced non‐alcoholic steatohepatitis.

Treatment potential of LPCN 1144 on liver health and metabolic regulation in a non-genomic, high fat diet induced NASH rabbit model

“…Finally, the pattern of IGF-1 mRNA expression between groups was consistent with ones observed in circulating and liver homogenates protein levels. This is in line with the reported literature showing inverse correlation between IGF-1 and fibrosis [55].…”

Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

“…While a few clinical studies have associated low serum IGF-1 with increased severity of steatosis ( 46 , 47 ) or lobular inflammation ( 48 ), our results and those of others ( 49 ) failed to show any association. On the other hand, clinical studies are consensual when reporting low serum IGF-1 association with the severity of fibrosis ( 46 , 48 – 50 ). In fact, in vitro and in vivo studies showed that IGF-1 can induce cellular senescence and hepatic stellate cell inactivation through a p53-dependent manner, thus improving experimental fibrosis ( 51 ).…”

Hepatocrinology

“…Serum IGF-1 levels are decreased in cirrhosis as the synthetic capacity of the liver is diminished [ 18 , 19 ]. Hepatic IGF-1 production is also lower in those with higher degrees of steatosis, non-alcoholic fatty liver disease (NAFLD) activity score (NAS), and hepatic fibrosis [ 20 , 21 ]. Conversely, NAFLD occurs more commonly in adult GHD.…”