Insulin-like growth factor 1 gene polymorphism in women with breast cancer

Abstract

Breast cancer is a disease of unknown etiology; however, the major risk factors are genetic alterations. Studies have demonstrated an association between insulin-like growth factor 1 (IGF-1) gene polymorphism and cell proliferation and reduced apoptosis, in addition to its role in breast cancer growth and aggressiveness. Two polymorphic variants of the IGF-1 gene are highlighted in association with breast cancer, rs6220 and rs7136446, although controversy exists as to this relationship. The current study included 137 women (68 breast cancer cases and 69 controls without breast cancer) who had 3 ml of peripheral blood drawn for the study of genomic DNA extracted from leukocytes using the genotyping technique by real-time polymerase chain reaction. The CC genotype (rs7136446) was present in 4 women (5.9%) from the case group and in 2 (3.0%) women from the control group (p = 0.67), while the GG genotype (rs6220) occurred in 8 (11.5%) women from the case group and in 5 (7.2%) women from the control group (p = 0.75). No statistically significant difference was observed between the CC genotype of variant rs7136446 in premenopausal case and control women (p = 0.31), thus as there was also no significant difference between case and control postmenopausal women (p = 1.00). Concerning the GG genotype of rs6220, it occurred in 6 (14.2%) premenopausal case and 4 (8%) control women (p = 0.71) and no difference was found in postmenopausal women (p = 1.00). In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.

Genetic Polymorphisms of Insulin-Like Growth Factor 1 Are Associated with Osteosarcoma Risk and Prognosis

“…In a study recruiting 110 colorectal cancer cases and 137 breast cancer cases, the genetic polymorphisms of IGF-1 were evaluated. The authors reported that IGF-1 SNPs were correlated with cancer risk and prognosis [ 20 ]. In addition, another recent study provided some evidence that targeting IGF-1R might suppress osteosarcoma progression, highlighting the role that the IGF-1 family plays in osteosarcoma [ 21 ].…”

Assessment of IGF-1 expression in the peripheral blood of women with recurrent breast cancer

“…[ 6 ] Therefore, breast cancer is a multifactorial disease, and one of the main risk factors is genetic alterations. [ 7 – 9 ] In this regard, one of the genes to draw attention due to its possible association with breast cancer tumorigenesis is the insulin-like growth factor 1 (IGF-1) gene. IGF-1 is located on the long arm of chromosome 12 and covers an area of over 80 kb of genomic DNA.…”

Influence of Insulin-Like Growth Factor 1 Gene Expression in Women with Breast Cancer: A Systematic Review

“…For the year 2018, approximately 2.1 million new cases of breast cancer were estimated to occur worldwide [3]. Breast cancer is a complex disease of unknown and multifactorial etiology, in which one of the main risk factors is genetic alteration [4,5]. Thus, genetic mutations of breast cancer (BRCA) 1 and 2 genes are related to the increased risk of hereditary breast and ovarian cancer over time [6], however, the participation of genes in breast cancer has not yet been fully elucidated [4,5].…”

“…Breast cancer is a complex disease of unknown and multifactorial etiology, in which one of the main risk factors is genetic alteration [4,5]. Thus, genetic mutations of breast cancer (BRCA) 1 and 2 genes are related to the increased risk of hereditary breast and ovarian cancer over time [6], however, the participation of genes in breast cancer has not yet been fully elucidated [4,5]. Thus, changes in expression levels of the insulin-like growth factor 1 [IGF-1] gene have been evaluated in breast cancer, however, there is a need for further elucidation of the association between changes in IGF-1 levels and increase in the risk, survival, and disease progression of breast cancer [7,8].…”

“…The IGF system consists of two peptidic hormones (IGF-1 and IGF-2), two cell surface receptors (IGF-1R and IGF-2R), and at least six IGF-binding proteins [IGFBP [1][2][3][4][5][6]] that control normal growth and differentiation in most tissues [9,10]. The effects of free IGF-1 protein, which represent about 1% of the circulating proteins, are mediated by IGF-1R [11].…”