Insulin-Like Growth Factor-1 as a Vascular Protective Factor

Conti, Elena; Carrozza, Cinzia; Capoluongo, Ettore; Volpe, Massimo; Crea, Filippo; Zuppi, Cecilia; Andreotti, Felicita

doi:10.1161/01.cir.0000144309.87183.fb

Cited by 227 publications

(178 citation statements)

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“…IGF-I has been shown to be a strong profibrogenic mediator, acting as a potent mitogen (24) and stimulator of collagen synthesis (19,24). Liver principally produces serum IGF-I (7,14) as a result of growth hormone induction. In addition, a number of different cells (such as fibroblasts and endothelial cells) may also release IGF-I (14,27).…”

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confidence: 99%

“…Liver principally produces serum IGF-I (7,14) as a result of growth hormone induction. In addition, a number of different cells (such as fibroblasts and endothelial cells) may also release IGF-I (14,27). Lung macrophages are the cells responsible for the IGF-I synthesis and release in adult patients with idiopathic pulmonary fibrosis (27) and other fibrotic lung diseases (20), including interstitial lung disease in children (20,24).…”

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confidence: 99%

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Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants

Capoluongo

Ameglio

Lulli

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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Preterm newborns developing retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) show persistently low levels of insulin-like growth factor-I (IGF-I) in sera. They also present higher free IGF-I concentrations in epithelial lining fluids (ELFs) and lung tissues. Pregnancy-associated plasma protein-A (PAPP-A) is a metalloproteinase that dissociates three binding proteins from the active form of IGF-I, namely free IGF-I. The present study analyzes the ELF concentrations of free IGF-I, PAPP-A, and their ratios in preterm newborns developing or not BPD, defined as O2 dependence at 36 wk postmenstrual age. Bronchoalveolar lavage fluids of 41 infants (34 without and 7 with BPD) were analyzed on the 2nd and 4th day after birth. Infants developing BPD showed increased ELF free IGF-I and decreased PAPP-A concentrations on both days 2 and 4 compared with newborns without BPD. A nonsignificant trend between these 2 days was observed for free IGF-I (increasing) and PAPP-A (decreasing). On the same days, the free IGF-I-to-PAPP-A ratio was always significantly higher in patients developing BPD. These differences were more significant than those of IGF-I or PAPP-A when individually evaluated. A multivariate analysis confirmed the significance for free IGF-I on day 4, whereas the ratio was confirmed on both days 2 and 4. The same ratio was significantly correlated with some indexes of disease severity, such as hours of oxygen administration, days of hospitalization, and ROP severity scores. Finally, the ratio between ELF free IGF-I and PAPP-A appears to be a useful marker for lung injury of premature newborns.

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confidence: 99%

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confidence: 99%

Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants

Capoluongo

Ameglio

Lulli

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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“…21 In the present study, we showed that CPT%PDV was positively associated with plasma free IGF-I in the entire study population, and subjects with vasospasm to intracoronary acetylcholine had lower plasma free IGF-I and CPT%PDV than the others. IGF-I has been known to protect directly against endothelial dysfunction, atherosclerotic plaque development, clinical instability, and ischemic myocardial damage by induction of NO production, 8 although it had been considered a mediator of cardiovascular disease previously. 8,22,23 Therefore, CPT%PDV may act as a marker of coronary endothelial function.…”

Section: Discussionmentioning

confidence: 99%

“…IGF-I has been known to protect directly against endothelial dysfunction, atherosclerotic plaque development, clinical instability, and ischemic myocardial damage by induction of NO production, 8 although it had been considered a mediator of cardiovascular disease previously. 8,22,23 Therefore, CPT%PDV may act as a marker of coronary endothelial function. sCD40L is an inflammatory mediator that promotes the various stages of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…endothelial dysfunction. 8 Several studies demonstrate that plasma C-reactive protein (CRP), adipocytokines and soluble CD40 ligand (sCD40L) act as atherosclerotic biomarkers and are independently associated with cardiovascular events. 7,9,10 Development in ultrasound technology has made it possible to assess blood flow in the distal left anterior descending coronary artery (LAD) with transthoracic Doppler echocardiography (TTE).…”

Section: Introductionmentioning

confidence: 99%

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Change of Coronary Flow Velocity During the Cold Pressor Test Is Related to Endothelial Markers in Subjects With Chest Pain and a Normal Coronary Angiogram

Hwang

Youn

Lee

et al. 2011

Clinical Cardiology

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Background: Several studies demonstrated that endothelial or atherosclerotic biomarkers, including plasma free insulin-like growth factor-I(IGF-I), soluble CD40 ligand (sCD40L), adiponectin, and leptin have an influence on coronary endothelial function. Hypothesis: The aim of the present study was to investigate whether change of coronary flow velocity of the distal left anterior descending artery (LAD) during the cold pressor test (CPT) with transthoracic Doppler echocardiography (TTE) was associated with these biomarkers in subjects with chest pain and a normal coronary angiogram. Methods: In 190 subjects (mean age, 54 ± 11 years; male:female, 113:77) with chest pain and a normal coronary angiogram, peak diastolic velocity (PDV) of the distal LAD during the CPT with TTE was assessed. Acetylcholine provocation test was performed in 58 subjects (mean age, 51 ± 10 years) who were clinically suspected of vasospasm. CPT%PDV was defined as the percent change in PDV during the CPT. Associations between CPT%PDV and clinical parameters were analyzed. Results: According to multiple regression analysis, CPT%PDV was associated with plasma free IGF-I in the entire study population (β = 0.295, P < 0.001 in all subjects; β = 0.341, P = 0.001 in males; β = 0.243, P = 0.037 in females; β = 0.303, P = 0.002 in nonsmokers; and β = 0.256, P = 0.047 in smokers), and sCD40L in males (β = −0.269, P = 0.008)and smokers (β = −0.261, P = 0.046). Subjects with vasospasm to intracoronary acetylcholine had lower plasma free IGF-I(6.9 ± 3.3 vs 8.9 ± 3.4, P = 0.026) and CPT%PDV (8.8 ± 24.9 vs 52.7 ± 26.0, P < 0.001) than the others. Plasma adiponectin and leptin were not associated with CPT%PDV. Conclusions: Change of coronary flow velocity assessed using the CPT with TTE may be related to endothelial markers, especially plasma free IGF-I.

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Bioengineering Alginate for Regenerative Medicine Applications

Ruvinov

Cohen

2016

Biomaterials From Nature for Advanced Devices and Therapies

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Insulin-Like Growth Factor-1 as a Vascular Protective Factor

Cited by 227 publications

References 86 publications

Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants

Epithelial lining fluid free IGF-I-to-PAPP-A ratio is associated with bronchopulmonary dysplasia in preterm infants

Change of Coronary Flow Velocity During the Cold Pressor Test Is Related to Endothelial Markers in Subjects With Chest Pain and a Normal Coronary Angiogram

Bioengineering Alginate for Regenerative Medicine Applications

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