Insulin-like effects of vanadium: basic and clinical implications

Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line

“…Insulin, a peptide that binds to specific membrane tyrosine kinase receptors, initiates intracellular signalling that either results in the regulation of protein, lipid, carbohydrate and mineral metabolism, or cell differentiation and proliferation, depending on the involved pathways: phosphatidyl inositol-3 kinase (PI3-K) pathway for metabolic effects or mitogen-activated protein kinase (MAPK) pathway for cell proliferation and differentiation effects (Cheatham and Kahn 1995;Cohick and Clemmons 1993;LeRoith 2000). Vanadium insulinmimetic properties have been associated to the activity of tyrosine phosphatases and consequent activation of tyrosine kinase receptors, including the insulin receptor (Goldwaser et al 2000;Shechter et al 1995;Shisheva and Shechter 1993). In vertebrates, a major process regulated by insulin (and insulin-like growth factor 1) is linear bone growth (McCarthy et al 2000;Moriyama et al 2000).…”

New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L<sup>1</sup>)

“…The square pyramidal geometry around V 4+ is completed by water, EtOH and sulphate which have characteristics bands appeared in the spectrum. The spectrum also shows broad bands in the 3222 -3447 cm −1 region together with a band at 1604 cm −1 region assigned to ѵ(OH) and ∂(OH) vibrations of H 2 O molecule, respectively. Existence of strong band at 976 cm −1 is strong evidence for the coordination of vanadium ion with L 1 as it is characterized for V=O vibration in VO 2+ [25].…”

“…water and hot EtOH with ratio (1:9) to VOSO 4 solution (2 mmol, 0.44 g) dissolved in 100 ml redistilled water H 2 O. The reaction mixture was refluxed on a hot plate for 2 h. The complex was isolated in the pH range 5 -6.…”

“…The antibacterial activity of a common standard Antifungal Colitrimazole and antibiotic ampicillin was also recorded utilizing the same procedure as above at the same solvents and concentration. 2 O, respectively then completed to the mark (50 ml). In continuous variation (CV) study, a series of 10 ml solutions was prepared by mixing solutions of V 4+ and L 1 solutions in different ratios keeping the total molar concentration constant as 6 × 10 −3 M and the absorbance at 604 nm was recorded.…”

“…Vanadium complexes have various biological activities, for example, an insulin-like activity [1]- [2] and the de- (18), 432 (19), 392 (70), 312 (100), 104 (45), 78 (26), (64) (25), (52) (26). Anal.…”