Insulin-enhancing activity of a dinuclear vanadium complex: 5-chloro-salicylaldhyde ethylenediamine oxovanadium(V) and its permeability and cytotoxicity

Xie, Ming‐Jin; Yang, Xiaoda; Liu, Weiping; Yan, Shi‐Ping; Meng, Zhaohui

doi:10.1016/j.jinorgbio.2010.03.018

Cited by 58 publications

(18 citation statements)

References 38 publications

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“…Vanadium compounds possess some medicinal uses including antiviral, antiparasitic, antibacterial and also therapeutic potential in diabetes [9][10][11]. The origin of anticancer activity of vanadium compounds is disruption of cellular metabolism through the M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 3 generation of ROS and also their ability on DNA damage [9,12].…”

Section: Introductionmentioning

confidence: 99%

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

Kazemi

Rudbari

Mirkhani

et al. 2017

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

Kazemi

Rudbari

Mirkhani

et al. 2017

European Journal of Medicinal Chemistry

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“…Several vanadium complexes derived from Schiff bases have shown to normalize blood glucose level with high efficiency and low toxicity, even at low concentration. 14,15 Schiff bases with hydrazone type are of particular interest due to their biological properties. [16][17][18][19][20] In recent years, a number of vanadium complexes were prepared from tridentate hydrazones, because of their excellent coordination ability and facilitate preparation.…”

Section: Introductionmentioning

confidence: 99%

4-Fluoro-N'-(2-hydroxy-3-methoxybenzylidene) benzohydrazide and its Oxidovanadium(V) Complex: Syntheses, Crystal Structures and Insulin-enhancing Activity

Lei

Wang²,

Huo³

et al. 2016

ACSi

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A hydrated hydrazone compound, 4-fluoro-N'-(2-hydroxy-3-methoxybenzylidene)benzohydrazide monohydrate (H 2 L · H 2 O), was prepared and characterized by elemental analysis, HRMS, IR, UV-Vis and 1 H NMR spectroscopy. Reaction of H 2 L, kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; Hka) and VO(acac) 2 in methanol afforded a novel oxidovanadium(V) complex, [VO(ka)L]. The complex was characterized by elemental analysis, IR, UV-Vis and 1 H NMR spectroscopy. Thermal analysis was also performed. Structures of H 2 L and the complex were further confirmed by single crystal structural X-ray diffraction. The vanadium complex is the first structurally characterized vanadium complex of kojic acid. Insulin-mimetic tests on C2C12 muscle cells indicate that the complex significantly stimulated cell glucose utilization with cytotoxicity at 0.11 g L -1 .

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“…E-mail: wangning7903@yahoo.com.cn Oxovanadium(V) complexes with N-and O-containing ligands have been extensively investigated in recent years with respect to their remarkable efficiency as insulin mimetic compounds [1][2][3]. The interaction of simple vanadium species with ligands having pharmacological activity is of particular interest.…”

Section: Introductionmentioning

confidence: 99%

Oxovanadium(V) Complexes With Schiff Base Ligands: Synthesis, Structure, and Catalytic Property

Wang

Guo

2013

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-

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The reaction of [VO(acac) 2 ] with N,N'-ethylenebis(3-ethoxysalicylideneimine) (H 2 L 1 ) and N,N'-ethylenebis(3-methylsalicylideneimine) (H 2 L 2 ), respectively, in methanol, affords two new oxovanadium(V) complexes [VOL 1 ]·H 2 O (1) and [VOL 2 ] (2). Both complexes have been characterized by elemental analysis, i.r., and single crystal X-ray diffraction methods. The V atoms in the complexes are in distorted square pyramidal coordination. The dinegative Schiff base ligands coordinate to the metal atoms through phenolate and imine donor atoms. Both complexes have effective catalytic property for the sulfoxidation reaction.

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Insulin-enhancing activity of a dinuclear vanadium complex: 5-chloro-salicylaldhyde ethylenediamine oxovanadium(V) and its permeability and cytotoxicity

Cited by 58 publications

References 38 publications

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

Self-recognition of the racemic ligand in the formation of homochiral dinuclear V(V) complex: In vitro anticancer activity, DNA and HSA interaction

4-Fluoro-N'-(2-hydroxy-3-methoxybenzylidene) benzohydrazide and its Oxidovanadium(V) Complex: Syntheses, Crystal Structures and Insulin-enhancing Activity

Oxovanadium(V) Complexes With Schiff Base Ligands: Synthesis, Structure, and Catalytic Property

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