Insulin-dependent glucose metabolism in dairy cows with variable fat mobilization around calving

Weber, Claudia; Schäff, C.T.; Kautzsch, Ulrike; Börner, S.; Erdmann, Susanne; Görs, Solvig; Röntgen, Monika; Sauerwein, H.; Bruckmaier, Rupert M.; Metges, C. C.; Kuhla, Björn; Hammon, H.M.

doi:10.3168/jds.2016-11022

Cited by 41 publications

(57 citation statements)

References 61 publications

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“…The observed decreased insulin concentration in both groups postpartum is related to the onset of lactation when blood glucose concentrations are low as the mammary gland uses glucose for energy and the synthesis of lactose (Weber et al, 2016). This insulin pattern postpartum in dairy cows has been already described by several authors (Lucy, 2004;Gross et al, 2011;Weber et al, 2016). These results reflect that the infusion of 5-HTP is able to regulate calcium homeostasis without affecting regulatory pathways of carbohydrate and energy metabolism during early lactation.…”

Section: Discussionsupporting

confidence: 66%

“…Those results are in agreement with our previously presented results where glucose concentrations were not affected by prepartum 5-HTP infusions . The observed decreased insulin concentration in both groups postpartum is related to the onset of lactation when blood glucose concentrations are low as the mammary gland uses glucose for energy and the synthesis of lactose (Weber et al, 2016). This insulin pattern postpartum in dairy cows has been already described by several authors (Lucy, 2004;Gross et al, 2011;Weber et al, 2016).…”

Section: Discussionmentioning

confidence: 55%

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Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor

Hernández-Castellano

Hernández

Sauerwein

et al. 2017

Journal of Dairy Science

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Serotonin (5-HT) has been shown to be involved in calcium homeostasis, modulating calcium concentration in blood. In addition, 5-HT participates in a variety of metabolic pathways, mainly through the modulation of glucose and lipid metabolism. The hypothesis of the present study was that the prepartum administration of 5-hydroxy-l-tryptophan (5-HTP), a 5-HT precursor, would affect endocrine systems related to calcium homeostasis, and interact with other endocrine and metabolic pathways during the transition period. In this study, 20 Holstein dairy cows were randomly assigned to 2 experimental groups. Both groups received a daily i.v. infusion of 1 L of either 0.9% NaCl (control group; n = 10) or 0.9% NaCl containing 1 mg of 5-HTP/kg of BW (5-HTP group, n = 10). Infusions started d 10 before estimated parturition date and ended the day of parturition, resulting in a minimum of 4 d of infusion (8.4 ± 0.7 d of infusion). Until parturition, blood samples were collected before the daily infusions, and postpartum daily until d 7, and on d 30. Plasma concentrations of parathyroid hormone (PTH) were transiently increased at parturition and on d 1 in control cows. In the 5-HTP group PTH remained unchanged. The concentration of pyridinoline (PYD), an established marker for calcium release from the bone to the bloodstream, increased on d 1 postpartum only in the 5-HTP group. In control cows, PYD concentrations did not change on d 1 postpartum. Melatonin concentrations were slightly but significantly increased in the 5-HTP group compared with the control group. Insulin concentrations decreased in both groups postpartum. Before parturition, leptin concentrations decreased in both groups and remained at this level until d 30 postpartum. Plasma IgG concentrations decreased in both groups on d -1 postpartum. Haptoglobin increased in both groups on d -1 and remained at this level until d 7 postpartum. No differences between groups were observed for insulin, glucagon, IgG, leptin, adiponectin, and haptoglobin concentrations. The results obtained in the present study evidenced that 5-HT is regulating calcium homeostasis independent of PTH. The lack of treatment effects on IgG and on other hormones and metabolites indicates that 5-HTP did not affect these other metabolic pathways and the IgG concentration during the transition period.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 55%

Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor

Hernández-Castellano

Hernández

Sauerwein

et al. 2017

Journal of Dairy Science

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“…The effect of time was significant (P < 0.01). The observed transient state of hyperglycemia at calving was independent of treatment and has been previously documented in dairy cows, where a distinct transient increase in glycemia occurred at parturition (Janovick et al, 2011;Weber et al, 2016).…”

Section: Blood Glucosesupporting

confidence: 74%

Intravenous calcium infusion in a calving protocol disrupts calcium homeostasis compared with an oral calcium supplement

Wilms¹,

Wang²,

Doelman³

et al. 2019

Journal of Dairy Science

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“…Insulin plays a key role in regulating energy metabolism during the transition period in dairy cows (Weber et al . ). Therefore, insulin metabolism should be an important pathogenic factor for KET.…”

Section: Data Summary Of the Final Dataset Used For Analysesmentioning

confidence: 97%

Genome‐wide association study identifies energy metabolism genes for resistance to ketosis in Chinese Holstein cattle

et al. 2019

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Ketosis (KET) is one common metabolic disorder that occurs mainly in early lactation and affects the dairy industry with significant economic losses. Cows with ketosis have lower milk yield and reproductive performance and greater risk of other periparturient diseases. As a metabolic disease, the pathogenesis of KET is multifactorial. To better understand the genetic background of KET, a genome-wide association study was performed using the Illumina BovineSNP50 BeadChip. Single-step genomic BLUP methodology was used to incorporate genomic data into a threshold-liability model. Results of the GWAS are reported as the proportion of variance explained by 20-SNP windows. Six genomic regions on Bos taurus autosomes 10, 13, 14 and 25 showed association with KET. Most interestingly, several candidate genes, including previously reported genes (BMP4, HNF4A and APOBR) and newly identified genes (SOCS4, GCH1, ATG14, RGS6, CYP7A1 and MAPK3), are involved in insulin metabolism or lipid metabolism, implicating the contribution of energymetabolism-associated genes to the genetic basis of KET. Our results provide new information about the underlying biology and molecular mechanisms associated with KET. Future studies that combine genomic variation analysis and functional gene information may help elucidate the biology of KET.

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Insulin-dependent glucose metabolism in dairy cows with variable fat mobilization around calving

Cited by 41 publications

References 61 publications

Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor

Endocrine and metabolic changes in transition dairy cows are affected by prepartum infusions of a serotonin precursor

Intravenous calcium infusion in a calving protocol disrupts calcium homeostasis compared with an oral calcium supplement

Genome‐wide association study identifies energy metabolism genes for resistance to ketosis in Chinese Holstein cattle

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