Intravenous calcium infusion in a calving protocol disrupts calcium homeostasis compared with an oral calcium supplement

Wilms, J.N.; Wang, Guanlin; Doelman, John; Jacobs, M.; Martín-Tereso, J.

doi:10.3168/jds.2018-15754

Cited by 20 publications

(24 citation statements)

References 22 publications

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“…For the purposes of this study, clinical hypocalcemia was defined as blood [Ca 2+ ] <1.10 mmol/L (Wilms et al, 2019) at any sampling time in combination with clinical signs as previously described. A cow was diagnosed with SCH if blood [Ca 2+ ] <1.10 mmol/L was determined at any time during the study but was not associated with apparent symptoms.…”

Section: Discussionmentioning

confidence: 99%

Effects of restricted dietary phosphorus supply to dry cows on periparturient calcium status

Wächter

Cohrs²,

Golbeck

et al. 2022

Journal of Dairy Science

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Restricted dietary P supply to transition dairy cows has recently been reported to beneficially affect the Ca balance of periparturient cows. The objective of the present study was to determine whether this effect on the Ca balance can be reproduced when limiting the P-restricted feeding to the last 4 wk of gestation. A total of 30 dairy cows in late pregnancy were randomly assigned to a dry cow diet with either low or adequate P content (0.16 and 0.30% P in DM, respectively) to be fed in the 4 wk before expected calving. After calving, all cows received the same lactating cow ration with adequate P content (0.46% P in DM). Blood was collected daily from 4 d antepartum until calving, at calving (d 0), 6 and 12 h after calving (d +0.25 and d +0.5, respectively) and on days +1, +2, +3, +4 and +7 relative to calving. Blood gas analyses were conducted to determine the concentration of ionized Ca in whole blood ([Ca 2+ ]), and plasma was assayed for concentrations of inorganic phosphorus ([Pi]), total calcium, parathyroid hormone ([PTH]), 1,25-dihydroxyvitamin D ([1,25-(OH) 2 D 3 ]), and CrossLaps ([CTX]), a biomarker for bone resorption (Immunodiagnostic Systems GmbH). Repeated-measures ANOVA was conducted to study treatment, time, and lactation number effects. The mean [Ca 2+ ] in P-deprived cows remained above the threshold of 1.10 mmol/L throughout the study, and values were higher compared with cows on adequate P supply between d 0 and d +2 and on d +4.The [Ca 2+ ] differed between treatments at the sampling times d 0, d +0.25, d +0.5, d +2, and d +4. Plasma [PTH] and [1, 2 D 3 ] did not differ between treatments, but P-deprived cows had greater [CTX] than cows with adequate P supply at d +1, d +2, and d +7. These results indicate that restricted dietary P supply to during the last 4 wk of the dry period improves the Ca homeostasis of these cows in the first days of lactation, an effect that seems to be primarily driven by increased bone tissue mobilization.

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Section: Discussionmentioning

confidence: 99%

Effects of restricted dietary phosphorus supply to dry cows on periparturient calcium status

Wächter

Cohrs²,

Golbeck

et al. 2022

Journal of Dairy Science

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“…Reasons for the aforementioned discrepancies are unclear, but may be explained by administration route, effects of secondary signals, or the confounding effects of yeast. Intravenous Ca is apparently detrimental to hormonal regulation of Ca when compared with oral delivery, and studies suggest it should not be used to treat SCH (Wilms et al, 2019). However, because Ca was purposely infused to avoid hypercalcemia, it is unlikely that signaling pathways controlling Ca status were meaningfully altered herein.…”

Section: Discussionmentioning

confidence: 99%

Effects of maintaining eucalcemia following immunoactivation in lactating Holstein dairy cows

Horst

Mayorga

Al‐Qaisi

et al. 2020

Journal of Dairy Science

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Periparturient hypocalcemia is a common metabolic disorder and it is ostensibly associated with negative health and production outcomes. Acute infection also markedly decreases circulating Ca, but the reasons for and consequences of it on physiological and immunological parameters are unknown. Objectives were to evaluate the effects of maintaining eucalcemia on production, metabolic, and immune variables following an intravenous lipopolysaccharide (LPS) challenge. Twelve multiparous lactating Holstein cows (717 ± 20 kg of body weight; 176 ± 34 d in milk; parity 3 ± 0.2) were enrolled in a study containing 2 experimental periods (P); during P1 (3 d), cows consumed feed ad libitum and baseline values were obtained. At the initiation of P2 (4 d), cows were randomly assigned to 1 of 2 treatments: (1) LPS administered (LPS-Con; 0.5 μg/kg of body weight LPS; n = 6) or (2) LPS administered + eucalcemic clamp (LPS-Ca; 0.5 μg/kg of body weight LPS; Ca infusion; n = 6). Cows were fasted for the first 12 h during P2. After LPS administration, ionized Ca was determined every 15 min for 6 h and every 30 min for an additional 6 h and intravenous Ca infusion was adjusted in LPS-Ca cows to maintain eucalcemia. Blood ionized Ca was decreased 23% for the first 12 h postbolus in LPS-Con cows, and by design, Ca infusion prevented hypocalcemia. To maintain eucalcemia for the 12 h, 13.7 g of Ca was infused. The total Ca deficit (including Ca not secreted into milk) accumulated over the 12 h was 10.4 and 20.2 g for the LPS-Con and LPS-Ca treatments, respectively. Mild hyperthermia (0.8°C) occurred for ~6 h post-LPS administration relative to P1. From 6 to 7 h postbolus rectal temperature from LPS-Ca cows was increased (0.6°C) relative to LPS-Con cows. On d 1 of P2, milk yield decreased (61%) in both treatments relative to P1. Relative to LPS-Con cows, milk yield decreased (15%) in LPS-Ca cows during P2. Overall, circulating LPS-binding protein continuously increased postbolus, and at 24 h LPS-binding protein levels in LPS-Ca cows were increased (80%) relative to LPS-Con cows. During P2, serum amyloid A increased (4-fold) in both treatments relative to P1. Administering LPS initially decreased circulating neutrophils, then cell counts progressively increased with time. Calcium infusion decreased neutrophil counts (40%) from 9 to 12 h postbolus relative to LPS-Con cows. Neutrophil function, as assessed by oxidative burst and myeloperoxidase production, did not differ due to treatment. In summary, maintaining eucalcemia (via intravenous Ca infusion) during an immune challenge appeared to intensify inflammation and adversely affect lactation performance.

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“…Hypocalcemia is a metabolic disorder in which homeostatic mechanisms fail to maintain normal blood Ca concentrations at the onset of lactation [ 20 , 29 ]. Although the incidence of clinical milk fever in the United States is approximately 5%, as many as 50% of periparturient dairy cows may have subclinical hypocalcemia, with total blood Ca concentrations being between 1.38 and 2.0 mM [ 7 , 18 ].…”

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confidence: 99%

Validation of the bovine blood calcium checker as a rapid and simple measuring tool for the ionized calcium concentration in cattle

Suzuki

Kondo

Takagi³

et al. 2021

J. Vet. Med. Sci.

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Point-of-care (POC) devices that veterinary practitioners can use to easily and rapidly measure blood ionized calcium (iCa) levels in cows immediately after withdrawing a blood sample on the dairy farm are needed. Aims of present studies was to compare the commercially available ion-selective electrode handheld iCa meter (bovine blood iCa checker) with the benchtop blood gas analyzer GEM premier 3500 and handheld analyzer i-STAT 1. Sixty-two paired-point whole blood samples were obtained from three cows with hypocalcemia experimentally induced by Na 2 -EDTA infusion. Whole blood samples were also obtained from the 36 cows kept on a farm in field conditions. The results using the bovine blood iCa checker correlated with those using the GEM premier 3500 and i-STAT 1. Bovine blood iCa checker was “compatible” with the GEM premier 3500 and i-STAT 1 because the frequency of differences between the measurements within ± 20% of the mean were 100% (65/65, >75%) and 90.8% (59/65, >75%), respectively. In the field trial, the blood iCa concentration measured by the bovine blood Ca checker was significantly positively correlated with that measured by the i-STAT 1 portable analyzer. Bovine blood iCa checker was “compatible” with the i-STAT 1 because the frequency of differences between the measurements within ± 20% of the mean was 100% (36/36, >75%). Results from these findings, the bovine blood iCa checker may be applied as a simplified system to measure the iCa concentration in bovine whole blood.

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Intravenous calcium infusion in a calving protocol disrupts calcium homeostasis compared with an oral calcium supplement

Cited by 20 publications

References 22 publications

Effects of restricted dietary phosphorus supply to dry cows on periparturient calcium status

Effects of restricted dietary phosphorus supply to dry cows on periparturient calcium status

Effects of maintaining eucalcemia following immunoactivation in lactating Holstein dairy cows

Validation of the bovine blood calcium checker as a rapid and simple measuring tool for the ionized calcium concentration in cattle

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