Insulin and insulin-like growth factor-1 action on human skeletal muscle: Preferential effects of insulin-like growth factor-1 in type 2 diabetic subjects

Ciaraldi, Theodore P.; Carter, Leslie; Rehman, N.; Mohideen, Pharis; Mudaliar, Sunder; Henry, Robert R.

doi:10.1053/meta.2002.34050

Cited by 22 publications

(15 citation statements)

References 44 publications

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“…Insulin binding to IR has been reported to be normal [52] or impaired [53,54]. Furthermore, tyrosine phosphorylation and/or activity of the IR has been reported to be normal [51,53,[55][56][57] or impaired [50,54,58] in skeletal muscle from non-obese and obese Type 2 diabetic subjects, compared with nondiabetic subjects.…”

Section: Insulin Signaling Defects Are Associated With Type 2 Diabetesmentioning

confidence: 99%

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

Karlsson

Zierath

2007

Cell Biochem Biophys

120

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Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular mechanism accounting for skeletal muscle insulin resistance in Type 2 diabetes. Furthermore, the effects of pharmaceutical treatment of Type 2 diabetic patients on insulin signaling and glucose uptake are discussed. The identification and characterization of pathways governing insulin action on glucose metabolism will facilitate the development of strategies to improve insulin sensitivity in an effort to prevent and treat Type 2 diabetes mellitus.

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Section: Insulin Signaling Defects Are Associated With Type 2 Diabetesmentioning

confidence: 99%

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

Karlsson

Zierath

2007

Cell Biochem Biophys

120

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“…39 In skeletal muscle cells of type II diabetic patients, IGF-1 was found to be a more potent stimulant of glucose transport than insulin itself. 40 The administration of recombinant human IGF-1 to diabetic patients can reduce insulin dose requirement by 50% and serum glucose levels by 23% 41 while improving glucose tolerance, hyperinsulinemia, and hypertriglyceridemia. 42,43 Even in normal volunteers, Figure 1.…”

Section: Igf-1 and The Metabolic Syndromementioning

confidence: 99%

Insulin-Like Growth Factor-1 as a Vascular Protective Factor

Conti¹,

Carrozza²,

Capoluongo³

et al. 2004

Circulation

225

162

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“…Low serum IGF1 levels are also associated with determinants of the metabolic syndrome including insulin resistance, serum leptin levels, waist-to-hip ratio, and type 2 diabetes mellitus (14)(15)(16)(17)(18). Moreover, low baseline levels of serum IGF1 predict an increased risk of fatal coronary events (19).…”

Section: Introductionmentioning

confidence: 99%

Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample

Völzke

Nauck²,

Rettig³

et al. 2009

European Journal of Endocrinology

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Context: It is assumed that hepatic steatosis plays a role in the development and progression of the metabolic syndrome and its cardiovascular sequelae. Low serum IGF1 levels might mediate these associations. Objectives: The aims of this study were i) to investigate the associations of hepatic steatosis with serum IGF1 and IGF binding protein-3 (IGFBP-3) levels using ultrasound and serum alanine aminotransaminase (ALT) data to define hepatic steatosis, and ii) to analyze the specific role of alcohol consumption in this context. Design: We analyzed data from the population-based Study of Health in Pomerania. Methods: We used data from 3863 subjects (1971 women) aged 20-79 years who had no history of viral hepatitis, liver cirrhosis, or malignant diseases. Liver hyperechogenicity was diagnosed using ultrasound. Serum IGF1 and IGFBP-3 levels were determined by automated two-site chemiluminescence immunoassays. Results: Hyperechogenic liver pattern was associated with low serum IGF1 levels and low serum IGF1/IGFBP-3 ratios. The lowest serum IGF1 and IGF1/IGFBP-3 values and highest IGFBP-3 levels were present in subjects who had a hyperechogenic liver pattern and increased serum ALT levels. All of these associations were independent of alcohol consumption. Conclusions: Our data show that hepatic steatosis is associated with low serum IGF1 levels. This association is independent of alcohol consumption.

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Insulin and insulin-like growth factor-1 action on human skeletal muscle: Preferential effects of insulin-like growth factor-1 in type 2 diabetic subjects

Cited by 22 publications

References 44 publications

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

Insulin-Like Growth Factor-1 as a Vascular Protective Factor

Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample

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