Insulin and HOMA in Spanish prepubertal children: Relationship with lipid profile

Garcés, Cármen; Cano, Beatriz; Granizo, Juan José; Benavente, Mercedes; Viturro, Enrique; Gutiérrez-Guisado, Javier; Oya, Iría de; Lasunción, Miguel A.; Oya, Manuel de

doi:10.1016/j.clinbiochem.2005.07.004

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…Plasma total FFA concentrations did not differ between children with and without AO, and the groups’ values were similar to those reported in the literature between 0.332 and 1.02 mmol/L [ 17 , 25 , 27 ]. According to the “fatty acid theory”, obesity induces insulin resistance in adipocytes, triggering higher lipolysis rate and increased fatty acid release; these alterations augment FFA concentration in blood [ 7 , 8 ].…”

Section: Discussionsupporting

confidence: 87%

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Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity

et al. 2018

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Increased plasma free fatty acids (FFAs) are associated with cardiometabolic risk factors in adults with abdominal obesity (AO). However, this association remains controversial in children. This study analyzed plasma FFA concentration in children with and without AO. Twenty-nine children classified with AO were matched by age and sex with 29 non-obese individuals. Blood samples were collected after fasting for 10–12 h. Plasma concentration of glucose, insulin, triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were determined by automatized methods. FFAs were analyzed by gas chromatography. Children with and without AO had similar age (7.1 ± 2.6 vs. 7.2 ± 2.7 years; p > 0.05) but obese children showed higher (p < 0.05) body mass index (BMI) (+4.3 kg/m2), systolic blood pressure (+5.1 mmHg), and insulin (+27.8 pmol/L). There were no significant differences in plasma total FFA concentration between groups (1.02 ± 0.61 vs. 0.89 ± 0.37 mmol/L; p > 0.05). However, children with AO had higher palmitoleic acid (0.94 vs. 0.70 wt %; p < 0.05) and dihomo-gamma linoleic acid (DHGL) (2.76 vs. 2.07 wt %; p < 0.05). Palmitoleic and DHGL acids correlated (p < 0.05) with BMI (r = 0.397; r = 0.296, respectively) and with waist circumference (r = 0.380; r = 0.276, respectively). Palmitoleic acid correlated positively with systolic blood pressure (r = 0.386; p < 0.05) and negatively with HDL-C (−0.572; p < 0.01). In summary, children with AO have higher plasmatic concentrations of free palmitoleic and DHGL fatty acids, which correlate with cardiometabolic risk factors.

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Section: Discussionsupporting

confidence: 87%

“…Most studies in children only report the total FFA concentration [ 18 , 19 , 25 , 26 , 27 ]. However, the FFA profile adds significant information given that different fatty acids might have diverse metabolic effects [ 6 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity

et al. 2018

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“…Thus, the association of overweight with elevated insulin levels also appears to be independent of DHEA‐S levels. As reported before in our population, insulin resistance seems to start to be present in our children (29). Although insulin levels were significantly higher in overweight children, other manifestations of insulin resistance, such as high glucose levels, were not present yet.…”

Section: Discussionsupporting

confidence: 86%

Dehydroepiandrosterone Sulfate and High‐density Lipoprotein‐cholesterol Levels in Overweight Children

Garcés

Cano

Lasunción

et al. 2007

Obesity

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“…Among 90 Pima Indian children aged 5 and 10 years, concentrations of insulin were similar in boys and girls aged 5 years but were higher in girls than in boys at the age of 10 years (32). In addition, many studies conducted in other countries have also reported higher circulating concentrations of insulin in females than in males (33)(34)(35)(36)(37)(38). However, in some studies no sex differences were found (38,39).…”

Section: Research Design Andmentioning

confidence: 97%

Age, Sex, and Ethnic Variations in Serum Insulin Concentrations Among U.S. Youth

Ford

Imperatore

et al. 2006

Diabetes Care

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OBJECTIVE—Distributions of serum concentrations of insulin among adolescents and young adults are poorly understood in the U.S. The objective of this study was to describe the distribution of serum insulin across demographic characteristics of U.S. adolescents and young adults. RESEARCH DESIGN AND METHODS—A total of 1,791 male and female subjects aged 12–19 years who participated in the National Health and Nutrition Examination Surveys for 1999–2002 were included in the analyses. RESULTS—Among male participants, serum concentrations of insulin increased from age 12 to 14 years before decreasing. Among female participants, concentrations were highest at age 13 years before decreasing steadily through age 19 years. Among participants aged 12–17 years but not those aged 18–19 years, females had higher mean log-transformed concentrations than males (P, Wald, F = 0.038 and 0.125, respectively) after adjusting for age and ethnicity. After adjusting for age and BMI percentile, mean log-transformed concentrations were higher in African-American females aged 12–17 years than in white or Mexican-American participants. No significant ethnic differences were found among female participants aged 18–19 years or male participants aged 12–19 years. Concentrations of insulin increased strongly with increasing levels of BMI. CONCLUSIONS—These results provide detailed information about serum concentrations of insulin in a representative sample of U.S. adolescents and young adults and may be useful to monitor future trends of this risk factor for diabetes and cardiovascular disease.

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Insulin and HOMA in Spanish prepubertal children: Relationship with lipid profile

Cited by 11 publications

References 25 publications

Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity

Concentrations of Plasma Free Palmitoleic and Dihomo-Gamma Linoleic Fatty Acids Are Higher in Children with Abdominal Obesity

Dehydroepiandrosterone Sulfate and High‐density Lipoprotein‐cholesterol Levels in Overweight Children

Age, Sex, and Ethnic Variations in Serum Insulin Concentrations Among U.S. Youth

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