Insulin and glucagon secretion by renal adenocarcinoma

Pavelić, Krešimir; Popovic, M

doi:10.1002/1097-0142(19810701)48:1<98::aid-cncr2820480119>3.0.co;2-a

Cited by 41 publications

(17 citation statements)

References 10 publications

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“…Many tumours have been reported to be insulin-producing/ secreting in humans, such as: insulinoma (Yoshinobu et al, 1985), cervix carcinoma and corpus uteri carcinoma (Pavelic et al, 1982a), mammary and bronchial carcinoma (Greenberg et al, 1968), thoracic sarcomata and fibrosarcoma (Linscheer et al, 1967), renal adenocarcinoma (Pavelic & Pavelic, 1981). Hodgkin's and non-Hodgkin's lymphoma (Pavelic et al, 1982b;Pavelic & Vuk-Pavlovic, 1983).…”

Section: El4 Tumourmentioning

confidence: 99%

Insulin-tumour interrelationship in EL4 lymphoma or thymoma-bearing mice. I. Alloxan-diabetic or non-diabetic mice

Yam

Zilberstein²,

Fink³

et al. 1990

Br J Cancer

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Summary A study has been carried out in which a comparison was made between EU lymphoma (assumed to be an insulin-producing secreting tumour) and thymoma (an insulin-dependent tumour). Tumour development and incidence, 3H-thymidine incorporation and insulin content in tumours, the host's food intake, blood insulin, glucose and cholesterol were determined in non-diabetic and alloxan-diabetic mice. Whereas no significant differences were observed between the diabetic and non-diabetic EL4 tumour-bearing mice, the diabetic, thymoma tumour-bearing mice showed reduced tumour growth and lower tumour incidence as compared with their non-diabetic counterparts. Insulin administration to diabetic tumour bearing mice, enhanced 3H-thymidine incorporation in the thymoma tumour cells only, and the insulin content of the EM tumours was found to be higher than that of the thymoma tumours. Rapid diabetes remission was observed in the diabetic, EL4 tumour-bearing mice as compared with the thymoma tumour-bearing mice.

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Section: El4 Tumourmentioning

confidence: 99%

Insulin-tumour interrelationship in EL4 lymphoma or thymoma-bearing mice. I. Alloxan-diabetic or non-diabetic mice

Yam

Zilberstein²,

Fink³

et al. 1990

Br J Cancer

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“…One case noted increased levels of glucagon, which trended down after nephrectomy and presents the possibility of an endocrine mechanism of hyperglycemia (6). Another case detected elevation of anti-glutamic acid dehydroxylase (GAD) and antiislet cell antibodies, which also normalized following nephrectomy and suggested a possible insulin deprivation mechanism due to pancreatic dysfunction on the level of the beta-islet cell (5).…”

Section: Discussionmentioning

confidence: 99%

“…A review of the literature revealed 7 previously reported cases of RCC with hyperglycemia in the English literature that were available for review (4)(5)(6)(7)(8)(9)(10). Years of publication ranged from 1981 to 2016.…”

Section: Discussionmentioning

confidence: 99%

New onset hyperglycemia attributed to renal cell carcinoma

Gapp

Anwar

Parekh

et al. 2018

IRDR

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“…Çoğu hastada nefrektomi sonrası bu bozukluklar ortadan kalkmaktadır. Bu semptomlar tümör hücrelerinden birtakım hormonların salgılanabileceği fikrini akıllara getirmiştir ve yapılan çalışmalarda tümör ekstrelerinde insülin ve glukagon hormonlarına rastlanılmıştır (50 …”

Section: çEşitli Endokrin Anomalilerunclassified

Renal Hücreli Kanserde Paraneoplastik Sendromlar

İzol¹,

Kaplan²

2014

uob

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Genitoüriner kanserler arasında renal hücreli karsinom, hastaların yaklaşık üçte birinde paraneoplastik sendroma ait semptom ve bulguların görülebilmesiyle kendini gösteren bir patolojidir. Renal hücreli karsinom ile ilgili paraneoplastik sendromlar konstitüsyonel semptomları (örneğin; ateş, kaşeksi ve kilo kaybı) ve bunun yanı sıra spesifik metabolik ve biyokimyasal anormallikleri (örneğin; hiperkalsemi, nonmetastatik hepatik disfonksiyon, amiloidoz vb.) içermektedir. Paraneoplastik sendrom varlığı ne metastatik hastalık işareti ne de kötü prognoz göstergesidir. Renal hücreli karsinom ile ilgili paraneoplastik sendromların patofizyolojisi ve biyolojisinin anlaşılmasıyla birlikte, konstitüsyonel semptomlar veya metabolik anormallikler primer veya tekrarlayan hastalığın ilk belirtisi olabilir. Bu hastalarda, paraneoplastik sendromların doğru tanısı ve yönetimi hastaların palyatif tedavisinde önemli olabilir. RHK ile ilgili kaşeksi, ateş, karaciğer fonksiyon bozukluğu, anemi ve amiloidoz gibi paraneoplastik belirtilerin patofizyolojisi henüz tam olarak aydınlatılamamıştır. Hiperkalsemi dışındaki paraneoplastik sendromlarda geleneksel medikal tedaviler nadiren faydalıdır. Erken tanı ve etkin tedavi bu hastaların yaşam kalitesini ve prognozunu değiştirebilir. Bu derlemede, renal hücreli karsinom ile ilgili birçok paraneoplastik sendromun ortaya çıkış mekanizmalarıyla birlikte, bunların klinik yansımalarını ve bu önemli bozukluklar için mevcut tedavi seçeneklerini tartışacağız. (Üroonkoloji Bülteni 2014;13:130-134) Anah tar Ke li me ler: Paraneoplastik sendrom, renal hücreli kanser, hiperkalsemi Renal cell carcinoma which is among genitourinary cancers is a pathology presenting with signs and symptoms of paraneoplastic syndrome in almost one third of the affected patients. The paraneoplastic syndromes associated with renal cell carcinoma include constitutional symptoms (ie, fever, cachexia, and weight loss), as well as specific metabolic and biochemical abnormalities (ie, hypercalcemia, nonmetastatic hepatic dysfunction, amyloidosis, etc). The presence of a paraneoplastic syndrome in a patient with renal cell carcinoma is neither a marker of metastatic disease nor necessarily indicative of a poor prognosis. The importance of understanding the pathophysiology and biology behind the many paraneoplastic syndromes associated with renal cell carcinoma lies in the fact that the presence of these protean symptoms may be the initial presentation of either primary or recurrent disease. In these patients, the accurate diagnosis and management of paraneoplastic syndromes may be important in palliative management. Pathophysiology of paraneoplastic symptoms of RCC such as cachexia, fever, hepatic dysfunction, anemia, and amyloidosis, remains incomplete. Except for hypercalcemia, conventional medical therapies are seldom helpful in the treatment of paraneoplastic symptoms. An early diagnosis and effective treatment might improve quality of life and alter prognosis of these patients. In this review, we will describe the proposed...

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Insulin and glucagon secretion by renal adenocarcinoma

Abstract: A patient with histologically verified renal adenocarcinoma had dramatic increases in glucagon and insulin levels in plasma and in tumor tissue.

Cited by 41 publications

References 10 publications

Insulin-tumour interrelationship in EL4 lymphoma or thymoma-bearing mice. I. Alloxan-diabetic or non-diabetic mice

Insulin-tumour interrelationship in EL4 lymphoma or thymoma-bearing mice. I. Alloxan-diabetic or non-diabetic mice

New onset hyperglycemia attributed to renal cell carcinoma

Renal Hücreli Kanserde Paraneoplastik Sendromlar

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