Insulin Affects Glucose Uptake by Muscle and Mammary Tissues of Lactating Ewes

Leenanuruksa, D; Niumsup, P; McDowell, GH

doi:10.1071/bi9880453

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The recent report that insulin infusion can decrease mammary glucose a-v in sheep (Leenanuruksa et al, 1988) was not confirmed in the present study. Leenanuruksa et al (1988) were also infusing somatostatin into their animals and the decrease in mammary glucose a-v was seen after about 6 h of insulin infusion; hence, several factors could account for the different findings.…”

Section: Discussioncontrasting

confidence: 99%

“…Raising the plasma insulin concentration had no effect on the glucose a-v difference across the mammary gland, as found previously in studies with goats (Hove, 1978) and cattle (Laarveld et al, 1981(Laarveld et al, , 1985. The recent report that insulin infusion can decrease mammary glucose a-v in sheep (Leenanuruksa et al, 1988) was not confirmed in the present study. Leenanuruksa et al (1988) were also infusing somatostatin into their animals and the decrease in mammary glucose a-v was seen after about 6 h of insulin infusion; hence, several factors could account for the different findings.…”

Section: Discussionsupporting

confidence: 61%

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Insulin resistance of hind-limb tissues in vivo in lactating sheep

Vernon

Faulkner

Hay

et al. 1990

Biochemical Journal

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1. The effects of varying the plasma insulin concentration by infusion while maintaining euglycaemia by infusion of glucose on nutrient arterio-venous differences across the hind-limb and mammary gland in lactating and non-lactating sheep were investigated. 2. Insulin infusion increased the glucose arterio-venous difference across the hind-limb; this effect of insulin was decreased by lactation, suggesting that lactation induces insulin resistance in skeletal muscle. 3. Lactation increased but insulin infusion decreased the plasma concentrations of acetate, beta-hydroxybutyrate and non-esterified fatty acids. 4. Insulin infusion decreased the arterio-venous differences of acetate and hydroxybutyrate across the hind-limb; this effect of insulin is probably indirect, resulting from the decrease in plasma concentrations of these metabolites. 5. Infusion of insulin had no effect on the glucose arterio-venous difference across the mammary gland, but did decrease the oxygen arterio-venous difference. 6. The results suggest that lactation results in insulin resistance in skeletal muscle, at least with respect to glucose utilization; this should facilitate the preferential utilization of glucose by the mammary gland.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 61%

Insulin resistance of hind-limb tissues in vivo in lactating sheep

Vernon

Faulkner

Hay

et al. 1990

Biochemical Journal

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“…This is in keeping with the proposed mechanism of IGF-I in suppressing the secretion of insulin (Kawai et al 1990; Van Schravendijk, Heylen, Van der Brande & Pipeleers, 1990). It is of interest that mammary function was not compromised by the diminished concentrations of insulin, supporting ear¬ lier data suggesting that the mammary gland of rumi¬ nants is relatively insensitive to changes in insulin (Hove, I91c\a,b;Laarveld, Christensen & Brockman, 1981;Laarveld, Chaplin & Brockman, 1985;Leenanuruska, Niumsup & McDowell, 1988;Vernon, Faulkner, Hay et al 1990). Frequent milking on the day before infusion of IGF-I also attenuated the MBF response, but this effect was not completely abolished.…”

Section: Discussionsupporting

confidence: 52%

Milking frequency alters the milk yield and mammary blood flow response to intra-mammary infusion of insulin-like growth factor-I in the goat

Prosser¹,

Davis²

1992

Journal of Endocrinology

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The milk yield and mammary blood flow responses to close-arterial, intra-mammary infusion of IGF-I were investigated in five Saanen goats milked frequently or normally the day before. Animals were infused for 6 h with recombinant human IGF-I (1.3 nmol/min) and milked hourly following i.v. injection of oxytocin beginning 2 h before infusion and then every 2 h. On one occasion animals were milked five times (after i.v. injection of oxytocin) on the day before infusion and on the other they were milked twice, without oxytocin. The ratio of milk yield from the infused to that from non-infused gland increased by 17 +/- 4% (mean +/- S.E.M.) in goats milked twice the day before infusion and by 6 +/- 2% when the infusion was preceded by frequent milking. Maximal responses were obtained 4 h after the start of the infusion and differed significantly (P < 0.05), according to pretreatment milking. Blood flow through the infused gland rose in parallel to the milk yield response. At 5 h, when maximal levels were achieved, blood flow was 182 +/- 23% of the pre-infusion flow rate following twice-daily milking and 139 +/- 3% of the pre-infusion flow rate following more frequent milk removal. Thus, more frequent milk removal on the day before close-arterial infusion of IGF-I attenuated both the milk yield and mammary blood-flow response to the infusion of IGF-I.

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Hormonal Control of Energy and Protein Metabolism

McDowell

Annison

1991

Physiological Aspects of Digestion and Metabolism in Ruminants

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Insulin Affects Glucose Uptake by Muscle and Mammary Tissues of Lactating Ewes

Cited by 5 publications

References 30 publications

Insulin resistance of hind-limb tissues in vivo in lactating sheep

Insulin resistance of hind-limb tissues in vivo in lactating sheep

Milking frequency alters the milk yield and mammary blood flow response to intra-mammary infusion of insulin-like growth factor-I in the goat

Hormonal Control of Energy and Protein Metabolism

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