Insulation lifetime improvement of polyimide thin film neural implants

Ceyssens, Frederik; Puers, Robert

doi:10.1088/1741-2560/12/5/054001

Cited by 37 publications

(34 citation statements)

References 21 publications

(36 reference statements)

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“…256-channel polyimide-based neural probes ( Figure 1) aimed at interfacing rat sciatic nerves were fabricated using a process similar to [2] except a layer of gold (~150 nm) was used on the top of 50 nm platinum to facilitate electroplating. Iridium oxide (200 nm) was sputtered onto electrode sites to lower the AC impedance.…”

Section: Electrode Interconnect and Insertion Structure Fabricationmentioning

confidence: 99%

“…The authors of this paper, among many others, have long recognized these problems which prompted research of flexible neural probes based on polymers which would offer far better mechanical matching with the tissue while being very inert and durable. Despite a plethora of research [2,3], these electrodes were so far limited to a small channel counts-usually less than 100. Typically, commercial off-the-shelf (COTS) connectors and cables are used to route the signals toward the external circuitry.…”

Section: Introductionmentioning

confidence: 99%

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Polymer-CMOS Hybrid Neural Probes for Large-Scale Neuro-Electronic Interfacing

2018

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Achieving a stable, long-term connection with millions of neurons within living organisms remains one of the dreams of neuroscience. Silicon shank based probes lead the field in terms of pure channel count. On the other hand, polymer neural probes offer superior biocompatibility, ruggedness and lower cost. This work tries to merge these technologies while exploring new electronic and interconnect design methods, ultimately yielding a prototype of a polymer-CMOS hybrid neural probe with a gold bump interconnect along with an electronic design based on bipolar transistor input devices, pseudo-capacitive AC coupling and in-pixel digitization.

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Section: Electrode Interconnect and Insertion Structure Fabricationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymer-CMOS Hybrid Neural Probes for Large-Scale Neuro-Electronic Interfacing

2018

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“…These high channel-count devices have enabled novel experimental paradigms with acute and semi-chronic recording, but they have yet to be demonstrated as robust for chronic implantation in large animals. Thin silicon probes are fragile, and polymer-substrate probes commonly suffer from cracking (Kozai et al, 2015) and delamination between insulation and electrode (Ceyssens and Puers, 2015;Čvančara et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Argo: A 65,536 channel recording system for high density neural recordingin vivo

Sahasrabuddhe¹,

Khan²,

Ap³

et al. 2020

Preprint

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Here we demonstrate the Argo System, a massively parallel neural recording system based on platinum-iridium microwire electrode arrays bonded to a CMOS voltage amplifier array. The Argo system is the highest channel count in vivo neural recording system built to date, supporting simultaneous recording from 65,536 channels, sampled at over 32 kHz and 12-bit resolution. This system is designed for cortical recordings, compatible with both penetrating and surface microelectrodes. We have validated this system by recording spiking activity from 791 neurons in rats and cortical surface Local Field Potential (LFP) activity from over 30,000 channels in sheep. While currently adapted for head-fixed recording, the microwire-CMOS architecture is well suited for clinical translation. Thus, this demonstration helps pave the way for a future high data rate intracortical implant.

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“…The main goal of this research is to build a test framework, by combining the RAA test method and a Weibull probability model to evaluate the risk and progression of device failure. In the future, we will apply this framework to evaluate other organic and inorganic materials that are widely used in biomedical device packaging, such as polyimide [ 31 , 32 , 33 , 34 , 35 , 36 ], SiC [ 37 , 38 ], diamond-like carbon [ 39 , 40 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Stability Performance Analysis of Various Packaging Materials and Coating Strategies for Chronic Neural Implants under Accelerated, Reactive Aging Tests

et al. 2020

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Reliable packaging for implantable neural prosthetic devices in body fluids is a long-standing challenge for devices’ chronic applications. This work studied the stability of Parylene C (PA), SiO2, and Si3N4 packages and coating strategies on tungsten wires using accelerated, reactive aging tests in three solutions: pH 7.4 phosphate-buffered saline (PBS), PBS + 30 mM H2O2, and PBS + 150 mM H2O2. Different combinations of coating thicknesses and deposition methods were studied at various testing temperatures. Analysis of the preliminary data shows that the pinholes/defects, cracks, and interface delamination are the main attributes of metal erosion and degradation in reactive aging solutions. Failure at the interface of package and metal is the dominating factor in the wire samples with open tips.

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Insulation lifetime improvement of polyimide thin film neural implants

Abstract: By improving the lifetime and insulation impedance of polyimide insulation with one order of magnitude, this work increases the applicability of polyimide in chronic thin film neural implants considerably.

Cited by 37 publications

References 21 publications

Polymer-CMOS Hybrid Neural Probes for Large-Scale Neuro-Electronic Interfacing

Polymer-CMOS Hybrid Neural Probes for Large-Scale Neuro-Electronic Interfacing

The Argo: A 65,536 channel recording system for high density neural recordingin vivo

Stability Performance Analysis of Various Packaging Materials and Coating Strategies for Chronic Neural Implants under Accelerated, Reactive Aging Tests

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