Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques

Interfacing Liquid State Hyperpolarization Methods with NMR Instrumentation

“…On the other hand, stricter requirements on sample purity, composition and delivery exist. These applications are the subject of other reviews [ 95 – 97 ].…”

Recent advances in the application of parahydrogen in catalysis and biochemistry

“…The main advantages of PHIP schemes compared to DNP are their independency of any sophisticated experimental hardware and the opportunity to be implemented on any modern NMR spectrometer for few thousands of Euros. An overview of current PHIP instrumentations is given in a recent review by Schmidt et al 21 Other advantages are the use of inexpensive chemical compounds and the fast formation of the polarization within seconds. PHIP schemes can be employed at ambient temperature and are thus easily amenable for kinetic studies.…”

Metabolic Reactions Studied by Zero- and Low-Field Nuclear Magnetic Resonance

“…The entangled state of the 1 H nuclearspin pair can be converted into a magnetic state of the 13 C spin via a magnetic field sweep. 20,21 Preparing the molecules in a 13 C-polarized state facilitates the detection of metabolic transformations, since as long as a magnetic field of 1 µT is applied to the sample, the 13 C nuclei will remain polarized during chemical transformations. We show that the combination of PHIP and ZULF NMR enables the study of biological systems using magnetic resonance in portable devices, without the need for bulky permanent or superconducting magnets.…”