Instrumentation and Characterization of Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry

Chen, Huanwen; Lai, Jinhu; Zhou, Yu-Fen; Huan, Yanfu; Li, Jianqiang; Xie, Zhiyong; Wang, Zhi‐Chang; Luo, Mingbiao

doi:10.1016/s1872-2040(07)60079-6

Cited by 60 publications

(32 citation statements)

References 12 publications

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“…Although the chemical composition and origins of samples can change dramatically in different studies, solid surfaces, solutions, and liquid mixtures are usually the states to be characterized by ambient mass spectrometry. Solid surfaces are classic samples for analysis by DESI [2] and similar techniques such as DART [3], desorption-atmospheric pressure chemi-cal ionization (DAPCI) [45,46], dielectric barrier discharge ionization (DBDI) [47], and ionization by a lowtemperature plasma (LTP) [48]. Theoretically, there are no restrictions with respects to sample geometry, size, and weight.…”

Section: Samples Accessible For Analysis By Ambient Ionization Technimentioning

confidence: 99%

“…Obviously, solutions containing a high percentage of organic solvents are not perfectly compatible for in vivo characterization of biological surfaces, especially for diagnosis of patients with allergies. Other techniques such as DAPCI utilize water to efficiently generate the reagent ions [45,46,59,106] and, thus, have been proposed for in vivo characterization of biological surfaces. However, people might be afraid and thus behave abnormally once they see that a "bright fire" (i.e., a high voltage plasma) contacting their skin.…”

Section: In Vivo Analysismentioning

confidence: 99%

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What can we learn from ambient ionization techniques?

Chen

Gamez

Zenobi

2009

J. Am. Soc. Mass Spectrom.

227

178

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Ambient mass spectrometry-mass spectrometric analysis with no or minimal effort for sample preparation-has experienced a very rapid development during the last 5 years, with many different methods now available for ionization. Here, we review its range of applications, the hurdles encountered for its quantitative use, and the proposed mechanisms for ion formation. Clearly, more effort needs to be put into investigation of matrix effects, into defining representative sampling of heterogeneous materials, and into understanding and controlling the underlying ionization mechanisms. Finally, we propose a concept to reduce the number of different acronyms describing very similar embodiments of ambient mass spectrometry. (J Am Soc Mass

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Section: Samples Accessible For Analysis By Ambient Ionization Technimentioning

confidence: 99%

Section: In Vivo Analysismentioning

confidence: 99%

What can we learn from ambient ionization techniques?

Chen

Gamez

Zenobi

2009

J. Am. Soc. Mass Spectrom.

227

178

View full text Add to dashboard Cite

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“…DAPCI type sources are based around a high voltage corona discharge electrode [14][15][16]. Reagent or solvent molecules near the electrode are ionized and directed at the sample surface.…”

Section: Introductionmentioning

confidence: 99%

“…A sheath gas can be used to promote ionization through the introduction of solvents/reagents or, if the gas is heated, through thermal desorption [14,[17][18][19]. Additional DAPCI source descriptions and parameters can be found in a variety of articles [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Examples of applications where DAPCI type sources have been used include hydrocarbons [28], explosives detection [21,29,30], pharmaceuticals [17,24], imaging [31], and natural products [20,23].…”

Section: Introductionmentioning

confidence: 99%

Molecular Ionization-Desorption Analysis Source (MIDAS) for Mass Spectrometry: Thin-Layer Chromatography

Winter

Wilhide

LaCourse

2015

J. Am. Soc. Mass Spectrom.

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Abstract. Molecular ionization-desorption analysis source (MIDAS), which is a desorption atmospheric pressure chemical ionization (DAPCI) type source, for mass spectrometry has been developed as a multi-functional platform for the direct sampling of surfaces. In this article, its utility for the analysis of thin-layer chromatography (TLC) plates is highlighted. Amino acids, which are difficult to visualize without staining reagents or charring, were detected and identified directly from a TLC plate. To demonstrate the full potential of MIDAS, all active ingredients from an analgesic tablet, separated on a TLC plate, were successfully detected using both positive and negative ion modes. The identity of each of the compounds was confirmed from their mass spectra and compared against standards. Post separation, the chemical signal (blue permanent marker) as reference marks placed at the origin and solvent front were used to calculate retention factor (R f ) values from the resulting ion chromatogram. The quantitative capabilities of the device were exhibited by scanning caffeine spots on a TLC plate of increasing sample amount. A linear curve based on peak are, R 2 = 0.994, was generated for seven spots ranging from 50 to 1000 ng of caffeine per spot.

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“…Recently, breakthrough of mass [36,37]. After DESI, more than 20 ambient ionization techniques were further developed, including direct analysis in real time (DART) [38,39], surface desorption atmospheric pressure chemical ionization (DAPCI) [40,41], extractive electrospray ionization (EESI) [42], low temperature plasma (LTP) [43,44], and easy ambient sonic ionization (EASI) [45]. Two major advantages of ambient mass spectrometry are minimal sample pre-treatment and high-throughput MS analysis [46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Detection of trace levels of lead in aqueous liquids using extractive electrospray ionization tandem mass spectrometry

Liu

Zhang

Xiao

et al. 2012

Talanta

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a b s t r a c tA sensitive approach, based on semi-quantitative measurement of the characteristic fragments in multistage extractive electrospray ionization mass spectrometry (EESI-MS n ), was developed for fast detection of trace levels of lead in aqueous liquids including mineral water, lake water, tap water, energy drinks, soft drinks, beer, orange juice, and tea. A disodium ethylene-diamine-tetraacetic acid (EDTA) aqueous solution was electrosprayed to produce negatively charged primary ions which then intersected the neutral sample plume to generate anions of EDTA-Pb(II) complexes. The charged EDTA-Pb(II) complexes were characterized with multistage collision induced dissociation (CID) experiments. The limit of detection (LOD) using EESI-MS 3 was estimated to be at the level of 10 -13 g/mL for directly detecting lead in many of these samples. The linear dynamic range was higher than 2 orders of magnitude. A single sample analysis could be completed within 2 min with reasonable semi-quantitative performance, e.g., relative standard deviations (RSDs) for deionized water were 4.6-7.6% during 5 experimental runs (each of them had 10 repeated measurements). Coca-cola and Huiyuan orange juice, representative beverage samples with complex matrices, generated recovery rates of 91.5% and 129%, respectively. Our experimental data demonstrated that EESI-MS is a useful tool for the fast detection of lead in various solutions, and EESI-MS showed promises for fast screening of lead-contaminated aqueous liquid samples.

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Instrumentation and Characterization of Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry

Cited by 60 publications

References 12 publications

What can we learn from ambient ionization techniques?

What can we learn from ambient ionization techniques?

Molecular Ionization-Desorption Analysis Source (MIDAS) for Mass Spectrometry: Thin-Layer Chromatography

Detection of trace levels of lead in aqueous liquids using extractive electrospray ionization tandem mass spectrometry

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