Instantaneous phytosynthesis of gold nanoparticles via Persicaria salicifolia leaf extract, and their medical applications

Hosny, Mohamed; Fawzy, Manal

doi:10.1016/j.apt.2021.06.004

Cited by 40 publications

(25 citation statements)

References 86 publications

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“…Gold nanoparticles showed tremendous antioxidant properties toward common free radicals, e.g., DPPH. Prepared gold nanoparticles had excellent anti-ovarian cancer activity against Sw-626, SK-0V, and P cell lines [141]. In another study, the aqueous extract Centaurea behen was utilized for the simple and environmental production of gold nanoparticles.…”

Section: Synthesis Of Gold Nanoparticles Using Leaves: (2019-2021)mentioning

confidence: 99%

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

et al. 2021

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Nanotechnology emerged as a scientific innovation in the 21st century. Metallic nanoparticles (metal or metal oxide nanoparticles) have attained remarkable popularity due to their interesting biological, physical, chemical, magnetic, and optical properties. Metal-based nanoparticles can be prepared by utilizing different biological, physical, and chemical methods. The biological method is preferred as it provides a green, simple, facile, ecofriendly, rapid, and cost-effective route for the green synthesis of nanoparticles. Plants have complex phytochemical constituents such as carbohydrates, amino acids, phenolics, flavonoids, terpenoids, and proteins, which can behave as reducing and stabilizing agents. However, the mechanism of green synthesis by using plants is still highly debatable. In this report, we summarized basic principles or mechanisms of green synthesis especially for metal or metal oxide (i.e., ZnO, Au, Ag, and TiO2, Fe, Fe2O3, Cu, CuO, Co) nanoparticles. Finally, we explored the medical applications of plant-based nanoparticles in terms of antibacterial, antifungal, and anticancer activity.

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Section: Synthesis Of Gold Nanoparticles Using Leaves: (2019-2021)mentioning

confidence: 99%

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

et al. 2021

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“…Furthermore, the antioxidant efficiency of rGO-AuNPs could be accredited to the antioxidant potentiality of the P. salicifolia aqueous extract. 101 Vitamin C, which is used as a reference, achieved 14.25, 32.05, and 48.7% of DPPH removal at concentrations of 12.5, 25, and 50 μg/mL ( Figure 9 ), respectively, which are higher than that of rGO-AuNPs. All in all, the current results confirmed the good antioxidant capability of the rGO-AuNP nanocomposite against DPPH and its promising application in the scavenging of other free radicals in further studies.…”

Section: Resultsmentioning

confidence: 94%

“…Consequently, exogenous antioxidants are used in these conditions. Among these antioxidants, several metallic nanoparticles (e.g., AuNPs, AgNPs, and PtNPs) , and also nanocomposites (e.g., rGO-AuNPs) have been confirmed to have a good antioxidant efficiency …”

Section: Introductionmentioning

confidence: 99%

Catalytic and Medical Potential of a Phyto-Functionalized Reduced Graphene Oxide–Gold Nanocomposite Using Willow-Leaved Knotgrass

et al. 2021

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In the current study, a simple, environmentally friendly, and cost-effective reduced graphene oxide–gold nanoparticle (rGO-AuNP) nanocomposite was successfully phytosynthesized using the aqueous leaf extract of a common weed found on the Nile banks, Persicaria salicifolia , for the first time. The phytosynthesis of rGO-AuNPs was first confirmed via the color transformation from brown to black as well as throughvarious techniques such as transmission electron microscopy (TEM) and Raman spectroscopy. Two UV–vis peaks at 275 and 530 nm were observed for the nanocomposite with a typical particle size of mostly spherical AuNPs of 15–20 nm. However, other shapes were occasionally detected including rods, triangles, and rhomboids. Existing phytoconstituents such as flavonoids and glycosides in the plant extract were suggested to be responsible for the phytosynthesis of rGO-AuNPs. The excellent catalytic efficacy of rGO-AuNPs against MB degradation was confirmed, and a high antibacterial efficiency against Escherichia coli and Klebsiella pneumonia was also confirmed. Promising antioxidant performance of rGO-AuNPs was also proved. Furthermore, it was concluded that rGO-AuNPs acquired higher efficiency than AuNPs synthesized from the same plant extract in all of the studied applications.

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“…Green synthesized AuNPs have been tested mostly against MCF-7 cancer cell line, and various ways in which AuNPs have interacted with MCF-7 cells have been reported, including alteration of the integrity of cell membranes, oxidative stress, interrupting physiological as well as metabolic processes, severing synthesis of ATP, halting the transfer of electrons, and finally, shrinking of cells and apoptosis [ 143 , 144 , 145 ]. Results of the study conducted by Devendiran et al [ 146 ] unveil the prodigious potential of AuNPs as carriers of chemotherapy drugs in drug delivery systems.…”

Section: Green Synthesis Of Aunps For Cancer Theranosticsmentioning

confidence: 99%

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

Sargazi

Laraib

et al. 2022

Nanomaterials

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Nanoparticles are currently used for cancer theranostics in the clinical field. Among nanoparticles, gold nanoparticles (AuNPs) attract much attention due to their usability and high performance in imaging techniques. The wide availability of biological precursors used in plant-based synthesized AuNPs allows for the development of large-scale production in a greener manner. Conventional cancer therapies, such as surgery and chemotherapy, have significant limitations and frequently fail to produce satisfying results. AuNPs have a prolonged circulation time, allow easy modification with ligands detected via cancer cell surface receptors, and increase uptake through receptor-mediated endocytosis. To exploit these unique features, studies have been carried out on the use of AuNPs as contrast agents for X-ray-based imaging techniques (i.e., computed tomography). As nanocarriers, AuNPs synthesized by nontoxic and biocompatible plants to deliver therapeutic biomolecules could be a significant stride forward in the effective treatment of various cancers. Fluorescent-plant-based markers, including AuNPs, fabricated using Medicago sativa, Olax Scandens, H. ambavilla, and H. lanceolatum, have been used in detecting cancers. Moreover, green synthesized AuNPs using various extracts have been applied for the treatment of different types of solid tumors. However, the cytotoxicity of AuNPs primarily depends on their size, surface reactivity, and surface area. In this review, the benefits of plant-based materials in cancer therapy are firstly explained. Then, considering the valuable position of AuNPs in medicine, the application of AuNPs in cancer therapy and detection is highlighted with an emphasis on limitations faced by the application of such NPs in drug delivery platforms.

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Instantaneous phytosynthesis of gold nanoparticles via Persicaria salicifolia leaf extract, and their medical applications

Cited by 40 publications

References 86 publications

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article

Catalytic and Medical Potential of a Phyto-Functionalized Reduced Graphene Oxide–Gold Nanocomposite Using Willow-Leaved Knotgrass

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

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