Insights on the pharmacological, phytochemical and ethnobotanical aspects of Artemisia roxburghiana: a rather less explored but therapeutically important species of lower Himalayas
“…A total of 170 compounds for molecular docking study were selected from our previous reports on the individual herbs of the present PHF and other antidiabetic agents. 11 , 17 , 19 , 21 , 24 , 27 Molecular interactions between protein-ligand complexes, including hydrogen bonds and other bonds, were analyzed and depicted using discovery studio software.…”
Section: Methodsmentioning
confidence: 99%
“…ex Besser (Compositae) is used as a traditional medicine in India for diabetes, rheumatic arthritis and malarial fever. 17 , 18 Earlier scientific studies revealed its antiprotozoal, anthelmintic, anti-inflammatory and antidiabetic potential. Various secondary metabolites such as taraxerol acetate, lupeol, friedelan-3β-ol, friedelin, betulinic acid, betulin, apigenin, artemisinin, apigenin-7,4-dimethyl ether, α-selinene, α-copaene, α-gurjunene, α-eudesmol, curcumene, caryophyllene oxide, β-selinene, germacrene D, β-eudesmol, δ-cadinene, bicyclogermacrene, artemisinin, scopoletin and quercetin have been reported from this plant.…”
“…A total of 170 compounds for molecular docking study were selected from our previous reports on the individual herbs of the present PHF and other antidiabetic agents. 11 , 17 , 19 , 21 , 24 , 27 Molecular interactions between protein-ligand complexes, including hydrogen bonds and other bonds, were analyzed and depicted using discovery studio software.…”
Section: Methodsmentioning
confidence: 99%
“…ex Besser (Compositae) is used as a traditional medicine in India for diabetes, rheumatic arthritis and malarial fever. 17 , 18 Earlier scientific studies revealed its antiprotozoal, anthelmintic, anti-inflammatory and antidiabetic potential. Various secondary metabolites such as taraxerol acetate, lupeol, friedelan-3β-ol, friedelin, betulinic acid, betulin, apigenin, artemisinin, apigenin-7,4-dimethyl ether, α-selinene, α-copaene, α-gurjunene, α-eudesmol, curcumene, caryophyllene oxide, β-selinene, germacrene D, β-eudesmol, δ-cadinene, bicyclogermacrene, artemisinin, scopoletin and quercetin have been reported from this plant.…”
“…It is characterized by its creeping rootstock, simple stem, deeply dissected wooly or nearly hairless leaves, and purplish flower heads in terminal and lateral spikes (Polunin and Stanton, 1990). In various Asian countries, the species is used as a folk remedy for the treatment of malaria, skin disorders, and intestinal worms, although its medicinal properties have not yet been scientifically validated (Joshi et al, 2016;Kumar et al, 2019) except in one recent report on its antidiabetic properties (Kumar et al, 2022).…”
“…The use of Artemisia species in traditional medicine is well-documented [ 5 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ] and demonstrates the great ethnopharmacological value of this genus. Artemisia annua L. and Artemisia absinthium L. are the best known for their uses in traditional medicine around of the World.…”
Section: Introductionmentioning
confidence: 99%
“…The Artemisia secondary metabolites belong to the several organic compounds families [ 44 , 47 , 48 , 49 ] such as terpenoids [ 14 , 44 ], mostly monoterpenes in essential oils [ 31 , 44 ] and sesquiterpene lactones [ 40 , 41 , 50 ], flavonoids [ 14 , 46 , 51 , 52 ], lignans [ 52 , 53 , 54 , 55 ], alkaloids [ 56 ], steroids [ 14 , 57 ], phenolic acids [ 37 , 47 , 58 ] and coumarins [ 14 , 53 , 59 ], all of them well known for their large range of biological activities.…”
The genus Artemisia, often known collectively as “wormwood”, has aroused great interest in the scientific community, pharmaceutical and food industries, generating many studies on the most varied aspects of these plants. In this review, the most recent evidence on health effects of edible Artemisia species and some of its constituents are presented and discussed, based on studies published until 2020, available in the Scopus, Web of Sciences and PubMed databases, related to food applications, nutritional and sesquiterpene lactones composition, and their therapeutic effects supported by in vivo and clinical studies. The analysis of more than 300 selected articles highlights the beneficial effect on health and the high clinical relevance of several Artemisia species besides some sesquiterpene lactones constituents and their derivatives. From an integrated perspective, as it includes therapeutic and nutritional properties, without ignoring some adverse effects described in the literature, this review shows the great potential of Artemisia plants and some of their constituents as dietary supplements, functional foods and as the source of new, more efficient, and safe medicines. Despite all the benefits demonstrated, some gaps need to be filled, mainly related to the use of raw Artemisia extracts, such as its standardization and clinical trials on adverse effects and its health care efficacy.
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