Insights into tyrosinase inhibition by compounds isolated from Greyia radlkoferi Szyszyl using biological activity, molecular docking and gene expression analysis

Lall, Namrita; Mogapi, Elizabeth; Canha, Marco Nuno De; Crampton, Bridget Genevieve; Nqephe, M.; Hussein, Ahmed A.; Kumar, Vivek

doi:10.1016/j.bmc.2016.09.054

Cited by 20 publications

(11 citation statements)

References 40 publications

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“…Tyrosinase inhibitory activity of many plant extracts was carried out to find new sources of anti-tyrosinase compounds. For example, anti-tyrosinase activities of the following plants have been reported by various researchers: Asphodelus microcarpus 133 , Morus nigra L 134 , Greyia radlkoferi Szyszyl 45 , Limonium tetragonum 135 , Arctostaphylos uva-ursi 136 , Pleurotus ferulae 137 , Agastache rugosa Kuntze fermented with Lactobacillus rhamnosus and Lactobacillus paracasei 138 , Artemisia aucheri Boiss 139 , Cassia tora 140 , S. brevibracteata subsp 141 , Rhodiola crenulata, Alpinia officinarum Hance and Zanthoxylum bungeanum Maxim 142 , Mangifera indica 143 , Podocarpus falcatus 144 , Momordica charantia 142 , Cymbopogon citrates 145 , Greyia flanaganii (IC 50 = 32.62 µg/ml) 146 , Vitis vinifera Leaf extracts (IC 50 = 3.84 mg/mL) 147 and Inula britannica L 146 …”

Section: Natural Tyrosinase Inhibitor Sourcesmentioning

confidence: 98%

A comprehensive review on tyrosinase inhibitors

Zolghadri

Bahrami

Khan³

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

758

471

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Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.

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Section: Natural Tyrosinase Inhibitor Sourcesmentioning

confidence: 98%

A comprehensive review on tyrosinase inhibitors

Zolghadri

Bahrami

Khan³

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

758

471

View full text Add to dashboard Cite

show abstract

“…The default docking parameters were employed for the docking study. It includes 100,000 genetic operations on a population size of 100 individuals and mutation rate of 95 as used by various recent studies [14][15][16] . The crystal structure of COX-2 from Homo sapiens was taken from the Protein Data Bank (PDB ID: 5IKR) 17 .…”

Section: Molecular Docking Of Cox-2mentioning

confidence: 99%

Antibacterial and Anticancer Activity of Ethnomedicinal Plants Used in the Jongilanga Community, Mpumalanga

Lall¹,

Mn²,

Reid³

et al. 2018

Phyto

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Seventy-four ethanolic extracts were prepared from traditionally used medicinal plants in the Jongilanga community in Mpumalanga South Africa. The aim was to determine the biological activity of the selected plants against cancer, mycobacteria species and acne. From the results, it was evident that Mundulea sericea was able to inhibit the proliferation of human melanoma cells (A375) with a fifty percent inhibitory concentration (IC50) ranging between 50 and 100 µg/ml as well as the ability to inhibit Mycobacterium tuberculosis, Mycobacterium smegmatis and Propionibacterium acnes with minimum inhibitory concentrations (MIC) of 125, 31.25 and 7.9 µg/ml respectively. This further led to the investigation of the antioxidant and anti-inflammatory activity as well as the influence of the extract on mycothiol disulphide reductase (Mtr) and glutathione reductase enzymes (Gtr) as potential targets against the above-mentioned diseases. M. sericea inhibited the COX-2 enzyme, responsible for inflammation, with an IC50 value of 10.70 ± 1.14 µg/ml, furthermore compounds previously isolated from M. sericea showed potential inhibition of COX-2 in molecular docking studies. Low radical scavenging capacity against the DPPH free radical with an IC50 value of 60.52 ± 2.40 µg/ml was obtained, however, M. sericea showed a higher affinity towards Mtr as compared to Gtr, which makes it an ideal plant for use as an antimycobacterial agent.

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“…Here, several plant extracts have proven to be more effective in targeting the inhibition of the oxidation of either L-DOPA or L-tyrosine. This is illustrated by the TYR assay results obtained for Haloxylon articulatum, Greyia radlkoferi, Pituranthos scoparius, Myrsine africana, Hyaenanche globose, and Cleome Arabica [40,45,57]. Additional studies also included extracts of Dolichopentas longiflora, where preparations exhibited a stimulatory response on melanogenesis, whereas the IC 50 value for TYR activity (26 ± µg/mL) showed contrasting results.…”

Section: Resultsmentioning

confidence: 99%

Tyrosinase and Melanogenesis Inhibition by Indigenous African Plants: A Review

et al. 2020

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The indiscriminate use of non-regulated skin lighteners among African populations has raised health concerns due to the negative effects associated with skin lightener toxicity. For this reason, there is a growing interest in the cosmetic development of plants and their metabolites as alternatives to available chemical-derived skin lightening formulations. Approximately 90% of Africa’s population depends on traditional medicine, and the continent’s biodiversity holds plant material with various biological activities, thus attracting considerable research interest. This study aimed to review existing evidence and document indigenous African plant species capable of inhibiting the enzyme tyrosinase and melanogenesis for potential incorporation into skin lightening products. Literature search on melanin biosynthesis, skin lightening, and tyrosinase inhibitors resulted in the identification of 35 plant species were distributed among 31 genera and 21 families across 15 African countries and 9 South African provinces. All plants identified in this study showed competent tyrosinase and melanogenesis inhibitory capabilities. These results indicate that African plants have the potential to serve as alternatives to current chemically-derived skin lighteners.

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Insights into tyrosinase inhibition by compounds isolated from Greyia radlkoferi Szyszyl using biological activity, molecular docking and gene expression analysis

Cited by 20 publications

References 40 publications

A comprehensive review on tyrosinase inhibitors

A comprehensive review on tyrosinase inhibitors

Antibacterial and Anticancer Activity of Ethnomedicinal Plants Used in the Jongilanga Community, Mpumalanga

Tyrosinase and Melanogenesis Inhibition by Indigenous African Plants: A Review

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