Insights into the swelling process and drug release mechanisms from cross-linked pectin/high amylose starch matrices

Carbinatto, Fernanda Mansano; Castro, André Luís da Silva; Evangelista, Raul Cesar; Cury, Beatriz Stringhetti Ferreira

doi:10.1016/j.ajps.2013.12.002

Cited by 150 publications

(89 citation statements)

References 53 publications

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“…The IPN beads prepared with lower amounts of polymer displayed higher water imbibition rates(Deshpande; due to their reduced matrix strength and greater porosity. However, the poor water retention capacity into 502 these matrices could result in decreased % swelling(Carbinatto et al, 2014).…”

mentioning

confidence: 99%

Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Bera¹,

Boddupalli²,

Nayak

2015

Carbohydrate Polymers

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mentioning

confidence: 99%

Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Bera¹,

Boddupalli²,

Nayak

2015

Carbohydrate Polymers

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“…The rate as a function of time (t n-1 ), the release constant K = 0.41 min -1 , correlation coefficient R 2 = 0.97 and diffusion exponent n = 0.49 were found for the 4 g.L -1 herbicide concentration, see Figure 13 (b). According to CARBINATTO et al 21 , the correlation between release exponent (n) values for the Korsmeyer-Peppas equation and drug release mechanisms depending on the geometry shape and for the sphere particle form 0.43< n< 0.85.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of a Controlled Release System of TBH Herbicide Using Alginate Microparticles

et al. 2016

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The development of controlled delivery system formulations has received increasing interest in the agriculture area. Tebuthiuron (TBH) is the most commonly used herbicide for weed control in sugar cane and cotton crops. The TBH and some of its metabolites are detected in surface water by leaching process, evidencing contamination and the need for an efficient process to decrease pesticide residues. The development of a controlled system release appears as a good solution. The present investigation aimed to study the development and evaluation of alginate microparticles as a delivery system for the TBH. The calcium alginate microparticles were prepared from the crosslinking of sodium alginate by Ca ++ containing varied amounts of TBH supplied in CaCl 2 aqueous solution. The particle size and morphological analysis of microparticles were determined by optical microscopy (OM) and by field emission gun scanning electron microscopy (FEG-SEM). The encapsulation efficiency and release of TBH studies was accessed by UV-vis spectroscopy. The results show that the polymeric microparticles containing TBH can be obtained successfully through a simple method and is suitable as a controlled release carrier system for herbicides and can be effective for controlling weeds.

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“…The drug release from swellable and hydrophilic matrices is controlled by physical and chemical process, involving the liquid penetration within the polymer network, the swelling of hydrated polymer, drug diffusion throughout swollen matrix and, sometimes, its erosion [45,46].…”

Section: Characterization Of Cf Loaded Pva/cs Cryogels By Ft-ir Spectmentioning

confidence: 99%

Poly (vinyl alcohol)/chitosan cryogels as PH responsive ciprofloxacin carriers

2016

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The pH responsiveness of swelling behavior and the release of ciprofloxacin hydrochloride from poly (vinyl alcohol)/chitosan cryogels of various compositions were investigated. All cryogels swelled and reached equilibrium within 100 min, indicating that the cryogels swell relatively fast. Increasing the chitosan content in the poly (vinyl alcohol) cryogels increased the swelling capacity of the cryogels. The poly (vinyl alcohol)/chitosan cryogels exhibited a sudden change in swelling characteristics at a certain pH value of the swelling medium as critical pH of 6.37-6.68 which depends on chitosan content. Ciprofloxacin hydrochloride was loaded into poly (vinyl alcohol)/chitosan cryogels to study its in-vitro release. Drug release behavior was found to be pHdependent. The release mechanism changes with pH of the medium and mainly at critical pH. The release rate is high in acidic medium (pH 4.5 and 5.5) as compared with basic one (pH 7.4), in the last pH medium the drug being delivered in a prolonged period and with a slow release rate. The pH responsiveness indicates that these systems are interesting drug carriers for the oral formulations or as wound dressing materials.

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Insights into the swelling process and drug release mechanisms from cross-linked pectin/high amylose starch matrices

Cited by 150 publications

References 53 publications

Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Mucoadhesive-floating zinc-pectinate–sterculia gum interpenetrating polymer network beads encapsulating ziprasidone HCl

Development and Evaluation of a Controlled Release System of TBH Herbicide Using Alginate Microparticles

Poly (vinyl alcohol)/chitosan cryogels as PH responsive ciprofloxacin carriers

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