Insights into the pivotal role of statins and its nanoformulations in hyperlipidemia

Singh, Sukhbir; Zahoor, Ishrat; Sharma, Neelam; Behl, Tapan; Kanojia, Neha; Sehgal, Aayush; Mohan, Syam; Almoshari, Yosif; Salawi, Ahmad; Aleya, Lotfi; Bungău, Simona

doi:10.1007/s11356-022-23043-3

Cited by 5 publications

(2 citation statements)

References 126 publications

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“…Statins are HMG-CoA reductase inhibitors used in the management of hypercholesterolemia or familial dyslipidemias [ 51 ] and for primary or secondary prevention of atherosclerotic vascular disease (ASCVD) [ 52 , 53 ].…”

Section: Role Of Statins In Managing Dyslipidemiamentioning

confidence: 99%

The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

Nartea

Mitoiu

Ghiorghiu

2023

CIMB

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Many investigations have discovered a connection between statins and magnesium supplements. On one hand, increasing research suggests that chronic hypomagnesemia may be an important factor in the etiology of some metabolic illnesses, including obesity and overweight, insulin resistance and type 2 diabetes mellitus, hypertension, alterations in lipid metabolism, and low-grade inflammation. Chronic metabolic problems seem to be prevented by a high Mg intake combined with diet and/or supplements. On the other hand, it is known that statins lower the frequency of cardiac events, stroke, and mortality, not by lowering LDL-C, but by the capacity to reduce mevalonate formation. That will enhance endothelial function, inhibit vascular smooth muscle cell proliferation and migration and encourage macrophages to promote plaque stability and regression while reducing inflammation. Taking these factors into consideration, we did an extensive analysis of the relevant literature, comparing the effects of Mg2 and statin medications on lipoproteins and, implicitly, on the key enzymes involved in cholesterol metabolism.

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Section: Role Of Statins In Managing Dyslipidemiamentioning

confidence: 99%

The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

Nartea

Mitoiu

Ghiorghiu

2023

CIMB

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“…Currently, the treatment methods for CHD combined with HLP mainly focus on reducing myocardial oxygen consumption [ 5 ] and improving myocardial blood circulation [ 6 ] while lowering blood lipid levels. Statins can stabilize vascular plaques, improve the function of endothelial cells, and most importantly, lower blood lipid levels by blocking the metabolic pathway of intracellular hydroxymethylglutaryl-coenzyme A and inhibiting cholesterol synthesis [ 7 ]. However, studies have shown that long-term use of statins can lead to abnormal liver and kidney functions, damage to nerves, muscles, and cardiovascular systems, and even death [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of oral Chinese patent medicines in the treatment of coronary heart disease combined with hyperlipidemia: a systematic review and network meta-analysis of 78 trials

Yang,

Li,

Zhou

et al. 2023

Chin Med

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Aim of the study To evaluate the clinical efficacy and safety of commonly used oral Chinese patent medicines for the treatment of coronary heart disease combined with hyperlipidemia in clinical practice through a network meta-analysis. Materials and methods PubMed, Embase, Cochrane Library, Web of Science, Wanfang, VIP, SinoMed, and CNKI databases were searched for all published randomized controlled trials (RCTs) on the treatment of coronary heart disease combined with hyperlipidemia using Chinese patent medicines. NoteExpress software was used to screen the literature obtained from the databases according to the inclusion and exclusion criteria. The Cochrane risk of bias assessment tool was used to evaluate the quality of the included studies. A network meta-analysis was performed using R 4.2.1. Subgroup analyses of outcome indicators were made based on conventional treatment (CT) methods. The incidence of adverse events in the included RCTs was statistically analyzed. A funnel plot was drawn using RevMan 5.4.1 software for the assessment of bias in the total clinical effectiveness rate. Finally, the quality of evidence for interventions with statistically significant differences was evaluated using the GRADE system. Results A total of 78 RCTs were included, involving 7,955 cases and 8 types of Chinese patent medicines, which were Tongxinluo Capsule, Naoxintong Capsule, Compound Danshen Dripping Pill, Shexiangbaoxin Pill, Songling Xuemaikang Capsule, Xuezhikang Capsule, Yindan Xinnaotong Capsule, and Zhibitai Capsule. A total of 24 RCTs reported the incidence of adverse events, but no statistically significant difference in the incidence of adverse events was found between the experimental and control groups in each study (P > 0.05). There was no obvious publication bias in all studies, but the overall quality of evidence in the included RCTs was low. Comparison of different intervention measures showed that Naoxintong Capsule + CT improved the cardiac index and cardiac output, and lowered the low-density lipoprotein cholesterol and total cholesterol levels. Tongxinluo Capsule + CT raised high-density lipoprotein cholesterol levels and reduced triglyceride levels. Xuezhikang Capsule + CT improved the total clinical effectiveness rate. Subgroup analyses showed that differences in CT did not cause heterogeneity in the results. Conclusion Compared with the use of CT alone, the combined use of Chinese patent medicines with CT can effectively improve the symptoms in patients with both coronary heart disease and hyperlipidemia.

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Polymethoxyflavones in citrus extract has a beneficial effect on hypercholesterolemia rats by promoting liver cholesterol metabolism

Du,

Su,

Yan

et al. 2024

Journal of Ethnopharmacology

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Insights into the pivotal role of statins and its nanoformulations in hyperlipidemia

Cited by 5 publications

References 126 publications

The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients

Efficacy and safety of oral Chinese patent medicines in the treatment of coronary heart disease combined with hyperlipidemia: a systematic review and network meta-analysis of 78 trials

Polymethoxyflavones in citrus extract has a beneficial effect on hypercholesterolemia rats by promoting liver cholesterol metabolism

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