Insights into the mechanisms of deep brain stimulation

Ashkan, Keyoumars; Rogers, Priya; Bergman, Hagai; Ughratdar, Ismail

doi:10.1038/nrneurol.2017.105

Cited by 261 publications

(208 citation statements)

References 78 publications

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“…Compared to purely inhibition theory, the filter effect of deep brain stimulation is more and more recognized. A moderate function is good (Ashkan, Rogers, Bergman, & Ughratdar, ; Chiken & Nambu, ; McIntyre, Savasta, Kerkerian‐Le Goff, & Vitek, ). In this study, high beta and gamma oscillations restore in the circuit after GPi‐DBS but exhibited sustained suppression after STN‐DBS.…”

Section: Discussionmentioning

confidence: 99%

Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome

et al. 2019

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IntroductionPrevious studies found subthalamic nucleus deep brain stimulation (STN‐DBS) has clinical effect on Parkinson's disease, dystonia, and obsessive compulsive disorder. It is noteworthy that only a few studies report the STN‐DBS for Tourette's syndrome (TS). Globus pallidus interna (GPi)‐DBS is the one of the most common targets for TS. So, this paper aims to investigate the neural oscillations in STN and GPi as well as the DBS effect between these two targets in same patients.MethodsThe local field potentials (LFPs) were simultaneously recorded from the bilateral GPi and STN in four patients with TS. The LFPs were decomposed into neural oscillations, and the frequency and time–frequency characteristics of the neural oscillations were analyzed across the conditions of resting, poststimulation, and movement.ResultsNo difference of resting LFP was found between the two targets. The poststimulation period spectral power revealed the high beta and gamma oscillations were recovered after GPi‐DBS but remained attenuated after STN‐DBS. The STN beta oscillation has fewer changes during tics than voluntary movement, and the gamma oscillation was elevated when the tics appeared.ConclusionThe high beta and gamma oscillations in GPi restored after GPi‐DBS, but not STN‐DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN‐DBS due to the influence on the hyper‐direct pathway but not GPi‐DBS.

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Section: Discussionmentioning

confidence: 99%

Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome

et al. 2019

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“…From cardiac arrhythmias to neurodegenerative disorders, maladaptive phenotypes in electrophysiology can result in serious and potentially deadly medical conditions 95,96 . In the case of neural dysfunction, deep brain stimulation (DBS) is the FDA approved standard of care for treating many of these disorders, including Parkinson’s disease, dystonia and essential tremor 97 .…”

Section: Discussionmentioning

confidence: 99%

Nongenetic Optical Methods for Measuring and Modulating Neuronal Response

Zimmerman

Tian

2018

ACS Nano

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The ability to sensitively probe and modulate electrical signals at cellular length-scale is a key challenge in the field of electrophysiology. Electrical signals play an integral role in regulating cellular behavior and in controlling biological function. From cardiac arrhythmias to neurodegenerative disorder, maladaptive phenotypes in electrophysiology can result in serious and potentially deadly medical conditions. Understanding how to monitor and control this behavior in a precise and non-invasive fashion represents an important step in developing next-generation therapeutic devices. As we develop a deeper understanding of neural network formation, electrophysiology has the potential to offer fundamental insights into the inner working of the brain. In this perspective, we will first explore traditional methods for examining neural function, briefly touching on recent genetic advances in electrophysiology, before turning to latest innovations in optical sensing and stimulation of action potentials in neurons. We will primarily focus our exploration on nongenetic optical methods, as these provide a high spatiotemporal resolution and can be achieved in a minimally invasive fashion.

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“…A consensus has not been reached about DBS therapeutic mechanisms, which are likely target and disease specific 55. DBS may provide benefit through different physiological mechanisms; for instance, DBS of the subthalamic nucleus in PD has been shown to modulate aberrant firing bursts, beta band oscillations and beta band coupling/synchronisation locally and within efferent structures like globus pallidus internal (GPi) 8 55.…”

Section: Methodsmentioning

confidence: 99%

Approaches to neuromodulation for schizophrenia

Gault

Davis

Cascella

et al. 2017

J Neurol Neurosurg Psychiatry

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Based on the success of deep brain stimulation (DBS) for treating movement disorders, there is growing interest in using DBS to treat schizophrenia (SZ). we review the unmet needs of patients with SZ and the scientific rationale behind the DBS targets proposed in the literature in order to guide future development of DBS to treat this vulnerable patient population. SZ remains a devastating disorder despite treatment. Relapse, untreated psychosis, intolerable side effects and the lack of effective treatment for negative and cognitive symptoms contribute to poor outcome. Novel therapeutic interventions are needed to treat SZ and DBS is emerging as a potential intervention. Convergent genetic, pharmacological and neuroimaging evidence implicating neuropathology associated with psychosis is consistent with SZ being a circuit disorder amenable to striatal modulation with DBS. Many of the DBS targets proposed in the literature may modulate striatal dysregulation. Additional targets are considered for treating tardive dyskinesia and negative and cognitive symptoms. A need is identified for the concurrent development of neurophysiological biomarkers relevant to SZ pathology in order to inform DBS targeting. Finally, we discuss the current clinical trials of DBS for SZ, and their ethical considerations. we conclude that patients with severe symptoms despite treatment must have the capacity to consent for a DBS clinical trial in which risks can be estimated, but benefit is not known. in addition, psychiatric populations should have access to the potential benefits of neurosurgical advances. CurreNT sTATe of TreATmeNT for sChizophreNiA► Schizophrenia (SZ) remains a devastating disorder despite antipsychotic, psychological and social treatments.

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Insights into the mechanisms of deep brain stimulation

Cited by 261 publications

References 78 publications

Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome

Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome

Nongenetic Optical Methods for Measuring and Modulating Neuronal Response

Approaches to neuromodulation for schizophrenia

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