Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens

Srivastava, Deepak P.; Woolfrey, Kevin M.; Penzes, Peter

doi:10.1124/pr.111.005272

Cited by 118 publications

(141 citation statements)

References 333 publications

(563 reference statements)

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“…All three ERs studied here, ER␣ (Milner et al, 2001), ER␤ (Milner et al, 2005), and GPER1 (Waters et al, 2015), have been localized to subsets of dendritic spines, excitatory axonal boutons, and glial processes within the CA1 region of the hippocampus using immunoelectron microscopy. Although the fraction of spines, boutons, or glia containing immunoreactivity for each extranuclear ER has not been reported, the heterogeneous distribution of ERs predicts that effects mediated by any one ER subtype should occur at only a subset of synapses, as we found.…”

Section: Synapse Specificity In Acute E2-induced Synaptic Potentiationmentioning

confidence: 87%

“…Although the physiological relevance of this effect initially was unclear, there is now compelling evidence that the hippocampus can synthesize estrogens as neurosteroids, which could provide a source of estrogens that fluctuate on the rapid time scale of E2-induced synaptic potentiation. For example, both the male and female hippocampus express the E2-synthesizing enzyme, P450 aromatase (Roselli et al, 1985;MacLusky et al, 1994;Hojo et al, 2004;Tabatadze et al, 2014), and hippocampal cultures (Prange-Kiel et al, 2003), and acute slices (Hojo et al, 2004) produce E2 in vitro. These observations have motivated efforts to understand the cellular mechanism(s) that underlie acute E2-induced synaptic potentiation.…”

Section: Introductionmentioning

confidence: 99%

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17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females

Oberlander

Woolley

2017

J. Neurosci.

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Estradiol (E2) acutely potentiates glutamatergic synaptic transmission in the hippocampus of both male and female rats. Here, we investigated whether E2-induced synaptic potentiation occurs via presynaptic and/or postsynaptic mechanisms and which estrogen receptors (ERs) mediate E2's effects in each sex. Whole-cell voltage-clamp recordings of mEPSCs in CA1 pyramidal neurons showed that E2 increases both mEPSC frequency and amplitude within minutes, but often in different cells. This indicated that both presynaptic and postsynaptic mechanisms are involved, but that they occur largely at different synapses. Two-photon (2p) glutamate uncaging at individual dendritic spines showed that E2 increases the amplitude of uncaging-evoked EPSCs (2pEPSCs) and calcium transients (2pCaTs) at a subset of spines on a dendrite, demonstrating synapse specificity of E2's postsynaptic effects. All of these results were essentially the same in males and females. However, additional experiments using ER-selective agonists indicated sex differences in the mechanisms underlying E2-induced potentiation. In males, an ER␤ agonist mimicked the postsynaptic effects of E2 to increase mEPSC, 2pEPSC, and 2pCaT amplitude, whereas in females, these effects were mimicked by an agonist of G protein-coupled ER-1. The presynaptic effect of E2, increased mEPSC frequency, was mimicked by an ER␣ agonist in males, whereas in females, an ER␤ agonist increased mEPSC frequency. Thus, E2 acutely potentiates glutamatergic synapses similarly in both sexes, but distinct ER subtypes mediate the presynaptic and postsynaptic aspects of potentiation in each sex. This indicates a latent sex difference in which different molecular mechanisms converge to the same functional endpoint in males versus females.

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Section: Synapse Specificity In Acute E2-induced Synaptic Potentiationmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females

Oberlander

Woolley

2017

J. Neurosci.

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“…Although not derived from investigations on neuronal plasticity, the list of nonhistone proteins targeted by HATs from the p300/CBP and MYST families (named for the founding members in yeast: MOZ, YBF2, SAS2 and TIP60) contains candidates such as STAT, NF-kB, steroid receptors, importin-a. They all contribute to processes underlying neuronal plasticity and learning (Nicolas et al 2013;Srivastava et al 2013;Snow et al 2014;Panayotis et al 2015) and therefore qualify as downstream targets of C646.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation

et al. 2016

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Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of longterm memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied garcinol, an inhibitor of the HATs of the p300 (EP300 binding protein)/CBP (CREB-binding protein) family, and the HATs of the PCAF (p300/ CBP-associated factor) family. As comparative agent we applied C646, a specific inhibitor that selectively blocks HATS of the p300/CBP family. Immunochemical analysis reveals differences in histone H3 acetylation in the honeybee brain, in response to the injection of either C646 or garcinol. Behavioral assessment reveals that the two drugs cause memory impairment of different nature when injected after associative conditioning: processes disturbed by garcinol are annihilated by the established transcription blocker actinomycin D and thus seem to require transcription processes. Actions of C646 are unaltered by actinomycin D, and thus seem to be independent of transcription. The outcome of our different approaches as summarized suggests that distinct HATs contribute to different acetylation-mediated processes in memory formation. We further deduce that the acetylation-mediated processes in memory formation comprise transcription-dependent and transcription-independent mechanisms.

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“…Neuroplastisitas dapat terjadi karena rangsangan sensorik dan motorik yang memasuki sistem saraf pusat sehingga terjadi perubahan neuron di otak (Srivastava, 2013;Matthies, 2013). Penelitian yang dilakukan Amagdei et al (2010) menunjukkan musik dapat mengubah cerebral hemodinamik yang mengaktivasi belahan otak kiri dan kanan.…”

Section: Study Neuropsychology Mengenai Paparan Musikunclassified

Mozart KV 448 Menurunkan Densitas dan Aktivitas Neuroglia Hipokampus Mencit (Mus musculus) Selama Stres Prenatal No. 416-KE

Kusumarini

Yustinasari

Hestianah

et al. 2017

Jurnal Sain Veteriner

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The aim of this research was to explore the influence of Mozart KV 448 classical music therapy to the neuroglia cells of mice's hippocampus that were exposed to stress during prenatal. This research were employing twenty female mices and twenty male mices. Female mices were estrus synchronized with PMSG and hCG then monomating to the males. Pregnant females were then divided into four groups (P0, P1, P2, P3). P0 was as control, P1 was treated by one minute forced swim test, P2 was treated by one minute forced swim test followed by thirty minutes classical music Mozart KV 448 and P3 was treated by one minute forced swim test followed by sixty minutes classical music Mozart KV 448. This research was carried out for twenty-one days during gestation period. The neuroglia density result was analyzed using ANOVA and Duncan test. The neuroglia activity result was analyzed using Kruskal wallis test and Z test. The histology reading showed degradation of density and activity of hippocampus neuroglia.Keywords: prenatal stress, classical music, Mozart KV 448, neuroglia, hippocampus AbstrakTujuan dari penelitian ini adalah untuk mengetahui pengaruh terapi musik klasik Mozart KV 448 pada densitas dan aktivitas dari sel neuroglia hipokampus anak mencit yang terpapar stres selama prenatal. Penelitian ini menggunakan 20 mencit betina dan 20 mencit jantan. Mencit betina kemudian di sinkronisasi estrus dengan PMSG dan hCG setelah itu dilakukan mono mating. Mencit betina yang positif bunting di bagi menjadi empat kelompok (P0, P1, P2, P3). P0 sebagai kontrol tidak diberikan perlakuan apapun, P1 diberikan terapi forced swim test selama satu menit, P2 diberikan terapi forced swim test selama satu menit diikuti musik klasik Mozart KV 448 selama 30 menit dan P3 diberikan terapi forced swim test selama satu menit diikuti musik klasik Mozart KV 448 selama 60 menit. Penelitian ini dilakukan selama 21 hari periode kebuntingan. Analisis data pada densitas neuroglia menggunakan ANOVA dan uji Duncan selanjutnya untuk aktivitas neuroglia data yang diperoleh berupa skor nilai tingkat perubahan aktivitas antar neuroglia sehingga menggunakan uji Kruskal wallis dan uji Z. Hasil gambaran histologi dari penelitian ini menunjukkan penurunan terhadap densitas dan aktivitas neuroglia hipokampus.

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Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens

Cited by 118 publications

References 333 publications

17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females

17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females

Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation

Mozart KV 448 Menurunkan Densitas dan Aktivitas Neuroglia Hipokampus Mencit (Mus musculus) Selama Stres Prenatal No. 416-KE

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