Insights into novel anticancer applications for apigenin

Kowalczyk, Adam; Bodalska, Agnieszka; Miranowicz, Marta; Karłowicz-Bodalska, Katarzyna

doi:10.17219/acem/41978

Cited by 23 publications

(12 citation statements)

References 32 publications

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“…Found plentifully in many medicinal plants and in many vegetables and fruits, apigenin, a naturally-occurring flavonoid, has several physiological functions [155,156]. It showed anticancer activity via JAK/STAT pathway inhibition by reducing phosphorylated JAK1/2 and STAT3 in breast cancer (BT-474) cells [25].…”

Section: Apigeninmentioning

confidence: 99%

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Bose¹,

Banerjee²,

Mondal³

et al. 2020

Cells

126

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Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis. Natural agents, including phytochemicals, exhibit potent anticancer activities via various mechanisms. However, the therapeutic potency of phytoconstituents as inhibitors of JAK/STAT signaling against cancer has only come into focus in recent days. The current review highlights phytochemicals that can suppress the JAK/STAT pathway in order to impede cancer cell growth. Various databases, such as PubMed, ScienceDirect, Web of Science, SpringerLink, Scopus, and Google Scholar, were searched using relevant keywords. Once the authors were in agreement regarding the suitability of a study, a full-length form of the relevant article was obtained, and the information was gathered and cited. All the complete articles that were incorporated after the literature collection rejection criteria were applied were perused in-depth and material was extracted based on the importance, relevance, and advancement of the apprehending of the JAK/STAT pathway and their relation to phytochemicals. Based on the critical and comprehensive analysis of literature presented in this review, phytochemicals from diverse plant origins exert therapeutic and cancer preventive effects, at least in part, through regulation of the JAK/STAT pathway. Nevertheless, more preclinical and clinical research is necessary to completely comprehend the capability of modulating JAK/STAT signaling to achieve efficient cancer control and treatment.

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Section: Apigeninmentioning

confidence: 99%

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Bose¹,

Banerjee²,

Mondal³

et al. 2020

Cells

126

View full text Add to dashboard Cite

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“…Apigenin is a flavonoid abundantly available in Apium leaves. It reportedly has anti-cancer properties [reviewed by Kowalczyk et al (2017)] and can enhance skeletal muscle hypertrophy and myoblast differentiation in mice (Jang et al, 2017). As aforementioned, the enzyme responsible for conversion of naringenin to apigenin is known and its manipulation leads to an increased level of apigenin (Tan et al, 2017).…”

Section: Breeding For Nutraceuticals and Food Safetymentioning

confidence: 99%

Celery and Celeriac: A Critical View on Present and Future Breeding

et al. 2020

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Cultivated for the crispy petioles and round, fleshy, and flavored hypocotyl celery and celeriac have over two centuries of breeding history in Europe. In this review paper we summarized the most recent advances touching when necessary the historical context of celery and celeriac breeding. In the post genomic era of research, the genome sequence of celery is only partially available. We comprised however in this paper the most important aspects of celery genetics that are available today and have applicability in celery modern cultivars development. We discussed the problems and traits that drive the main celery and celeriac breeding goals, like hybrid seed production, disease resistance, and interesting enlarged hypocotyl and petiole characteristics. Besides the classical breeding traits we covered the potential of integration of existing cultivars as sources for consumer oriented traits like nutraceuticals and health promoting substances. Sustainability is a subject that is continuously growing in popularity and we looked at the genetic base of celery and celeriac that makes them sources for abiotic stress resistance and candidates for phytoremediation. We explored the fundamental concepts gained in various fields of celery and related species research, as resources for future improvement of celery and celeriac germplasm. We forecast what the next years will bring to Apium breeding.

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“…Studies have shown that apigenin is a potent antioxidant, antiviral, antimicrobial and chemo preventive agent. [4][5][6][7] In the structure of this compound three hydroxyl groups together with double bonds at C2 and C3 are present. Such chemical structure provides that apigenin can acts as a phytoestrogen.…”

Section: Introductionmentioning

confidence: 98%

Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro

Jukić

Cvetanović

Špoljarić

et al. 2019

ACSi

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In the frame of this paper, the enzyme-assisted hydrolysis coupled with ultrasound and Soxhlet extraction was applied in order to get extracts of chamomile ligulate flowers (CLF). Obtained extracts were characterized in terms to their apigenin and apigenin glucoside composition, as well as antiproliferative potential against tumour cells. Antioxidant activity was determined by two different assays based on different mechanisms showing that autofermented extracts have higher reduction potential. Autofermented extracts prepared by ultrasound and Soxhlet extraction had a stronger impact on the treated carcinoma (HeLa and NCI-H358) and leukemia (K562) cells' growth reduction in comparison to the native extracts, 30-35% greater inhibition at the lowest concentration (0.01 mg/mL), in two observed time points (48 and 72 h). Leukemia cells are more sensitive to all tested extracts. The autofermented CLF extracts with highest antiproliferative efficacy induced morphological changes and apoptosis in the HeLa cells. Obtained results clearly showed that the combination of enzymatic hydrolysis with cavitation phenomenon results in extracts with higher apigenin content and increased biological potential.

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Insights into novel anticancer applications for apigenin

Cited by 23 publications

References 32 publications

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Celery and Celeriac: A Critical View on Present and Future Breeding

Autofermentation of Chamomile Ligulate Flowers Promote Antitumor Effects in vitro

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