Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic

Liang, Chengyuan; Ning, Hui; Liu, Yuzhi; Qiao, Guaiping; Li, Juan; Tian, Lei; Ju, Xingke; Jia, Minyi; Liu, Hong; Cao, Wenqiang; Yu, Pengcheng; Han, Li; Ren, Xiaodong

doi:10.1016/j.phyplu.2021.100027

Cited by 24 publications

(17 citation statements)

References 133 publications

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“…Previous studies have shown that inflammation and oxidative stress are also important factors in exacerbating organ fibrosis. Some studies have found that LianhuaQingwen Capsules (LHQW) can treat COVID-19 mainly through reducing the production of pro-inflammatory mediators TNF-α and IL-6, controlling the inflammatory storm, and decreasing EndoMT numbers, thereby reducing lung injury [119] . DHZC can effectively inhibit macrophage infiltration into tissues in the hepatic vascular niche, while inhibiting the PI3K/AKT pathway to attenuate abnormal activation of ECs and exert anti-hepatic fibrosis effects [120] .…”

Section: Treatment Strategies For Organ Fibrosis Using Western and Tr...mentioning

confidence: 99%

WITHDRAWN: The Role of the Vascular Niche in Organ Fibrosis and COVID-19-Related Organ Damage and the Countermeasures adopted by Chinese and Western Medicine

Zhou

Yang

Sui

et al. 2022

Pharmacological Research - Modern Chinese Medicine

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Section: Treatment Strategies For Organ Fibrosis Using Western and Tr...mentioning

confidence: 99%

WITHDRAWN: The Role of the Vascular Niche in Organ Fibrosis and COVID-19-Related Organ Damage and the Countermeasures adopted by Chinese and Western Medicine

Zhou

Yang

Sui

et al. 2022

Pharmacological Research - Modern Chinese Medicine

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“…In our research, Paxlovid was also proved to significantly reduced the period of viral PCR conversion in patients whose conditions were mild and moderate. As a traditional Chinese medicine, LHQW can significantly suppress the SARS-COV-2 replication affecting the morphology of viral granule and exerting antiviral activity in vitro (25,26). Some studies showed that it may improve the clinical symptoms of patients infected with SARS-COV-2, such as fever, fatigue and myalgia, but safety is not guaranteed if combined with conventional treatment (27).…”

Section: Discussionmentioning

confidence: 99%

Clinical advancement of patients infected with SARS-CoV-2 Omicron variant in Shanghai, China

Shao

Fan

Zhang

et al. 2022

Preprint

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Background Studies on the Omicron variant infection have generally been restricted to descriptions of its initial clinical and epidemiological characteristics, we investigated the timeline-related advancement in individuals with Omicron variant. Methods We conducted a retrospective, single centered study including 226 laboratory confirmed cases with Omicron variant between April 6th and May 11th, 2022 in Shanghai, China. Final date of follow-up was May 30, 2022. Results Among 226 enrolled patients, the median age was 52 years old, and 118 (52.2%) were female. The duration from onset of symptoms to hospitalization was 3 (IQR, 2-4) days for symptomatic patients. Cough occurred in 168 patients (74.3% ). The median interval to negative reverse-transcriptase PCR tests of nasopharynx swab was 10 days (interquartile range [IQR]: 8-13 days). No radiographic progressions were found in 196 patients on the 7th day after onset of symptoms. The median duration of fever in all participants was 5 days (IQR: 4-6 days). The median PCR conversion time of Paxlovid-treated patients was 8 days (IQR: 7-10 days) compared with that of Lianhuaqingwen (10 days, IQR: 8-13 days) (p=0.00056). Booster vaccination can significantly decrease the severity of Omicron infection when compared with unvaccinated, partially or fully vaccinated patients (p=0.009). The median time of PCR conversion in individuals aged under 14 recovered significantly faster than older patients (median 8 days versus 11 days, P < 0.0001). In multivariate logistic analysis, erythrocyte sedimentation rate (ESR) (OR=1.05) was independently related to the severity of the infection. Conclusions The majority clinical symptoms of Omicron infection were not severe. Early and aggressive administration of Paxlovid can significantly reduce the PCR conversion time. Booster vaccination should also be highly recommended in population over 14 years old.

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“…These studies seem to show that GF has a stronger heatclearing effect than RF (Nishibe, 2002;Dong et al, 2017;Wang et al, 2018). FF is the main ingredient of Forsythiae honeysuckle (Lian-Hua-Qing-Wen) prescription recommended in the TCM treatment protocol of COVID-19 in China (Liang et al, 2021). The better heat-clearing ability of GF (mainly based on the anti-inflammatory Frontiers in Pharmacology frontiersin.org properties) might explain the more frequent uses of GF in these TCM prescriptions (Nishibe, 2002;Dong et al, 2017;Wang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Better detoxifying effect of ripe forsythiae fructus over green forsythiae fructus and the potential mechanisms involving bile acids metabolism and gut microbiota

Wang

Qin

et al. 2022

Front. Pharmacol.

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Forsythiae Fructus (FF), the fruit of Forsythia suspensa (Thunb.) Vahl. (Lianqiao), is one of the most fundamental herbs in Traditional Chinese Medicines (TCM), mainly due to its heat-clearing and detoxifying effects. There are two types of FF, the greenish fruits that start to ripen (GF) and the yellow fruits that are fully ripe (RF), called “Qingqiao” and “Laoqiao” referred to the Chinese Pharmacopoeia, respectively. It undergoes a complex series of changes during the maturation of FF. However, the clinical uses and preparation of phytopharmaceuticals of FF have not been distinguished to date. Moreover, there is limited information on the study of the difference in pharmacological activity between RF and GF. In this study, a rat model of bile duct ligation (BDL)-induced cholestasis was used to compare the differences in their effects. RF was found to have better results than GF in addressing toxic bile acids (BAs) accumulation and related pathological conditions caused by BDL. The underlying mechanism may be related to the interventions of gut microbiota. The results of the present study suggest that the better detoxifying effect of RF than GF may be indirectly exerted through the regulation of gut microbiota and thus the improvement of BAs metabolism.

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Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic

Cited by 24 publications

References 133 publications

WITHDRAWN: The Role of the Vascular Niche in Organ Fibrosis and COVID-19-Related Organ Damage and the Countermeasures adopted by Chinese and Western Medicine

WITHDRAWN: The Role of the Vascular Niche in Organ Fibrosis and COVID-19-Related Organ Damage and the Countermeasures adopted by Chinese and Western Medicine

Clinical advancement of patients infected with SARS-CoV-2 Omicron variant in Shanghai, China

Better detoxifying effect of ripe forsythiae fructus over green forsythiae fructus and the potential mechanisms involving bile acids metabolism and gut microbiota

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