Insights into Adaptive Mechanisms of Extreme Acidophiles Based on Quorum Sensing/Quenching-Related Proteins

Huang, Shanshan; Liu, Xueduan; Yang, Weiyi; Ma, Liyuan; Li, Huiying; Liu, Rui; Qiu, Jingxuan; Li, Yiran

doi:10.1128/msystems.01491-21

Cited by 7 publications

(3 citation statements)

References 68 publications

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“…For example, some biofilm bacteria can produce QS-dependent enzymes that modify or degrade antimicrobial agents, reducing their effectiveness. The QS system is divided into four types, each using different signal molecules, including N-Acyl homoserine lactones (AHLs), such as autoinducer-2 (AI-2), and diffusible signaling factor (DSF) (Huang et al, 2022).…”

Section: Quorum Sensingmentioning

confidence: 99%

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

Pai,

Patil,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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Biofilms are a common survival strategy employed by bacteria in healthcare settings, which enhances their resistance to antimicrobial and biocidal agents making infections difficult to treat. Mechanisms of biofilm-induced antimicrobial resistance involve reduced penetration of antimicrobial agents, increased expression of efflux pumps, altered microbial physiology, and genetic changes in the bacterial population. Factors contributing to the formation of biofilms include nutrient availability, temperature, pH, surface properties, and microbial interactions. Biofilm-associated infections can have serious consequences for patient outcomes, and standard antimicrobial therapies are often ineffective against biofilm-associated bacteria, making diagnosis and treatment challenging. Novel strategies, including antibiotics combination therapies (such as daptomycin and vancomycin, colistin and azithromycin), biofilm-targeted agents (such as small molecules (LP3134, LP3145, LP4010, LP1062) target c-di-GMP), and immunomodulatory therapies (such as the anti-PcrV IgY antibodies which target Type IIIsecretion system), are being developed to combat biofilm-induced antimicrobial resistance. A multifaceted approach to diagnosis, treatment, and prevention is necessary to address this emerging problem in healthcare settings.

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Section: Quorum Sensingmentioning

confidence: 99%

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

Pai,

Patil,

Liu

et al. 2023

Front. Cell. Infect. Microbiol.

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“…A comprehensive QS database containing QS proteins described as involved in QS and QQ were downloaded using the application programming interface (https://rest.kegg.jp/). The QS gene sequences from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (KO:02024) and references related to QS systems were used as the basic data [17,34]. The genes involved in the synthesis, sensing, quenching, and transport of signal molecules were selected, and all amino acid sequences from the selected KEGG Orthologs (KOs) were retrieved (accessed in January 2023).…”

Section: Quorum Sensing Databasementioning

confidence: 99%

Metabolic activities of marine ammonia-oxidizing archaea orchestrated by quorum sensing

Pereira,

Qin,

Galand

et al. 2023

Preprint

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Ammonia-oxidizing archaea (AOA) play crucial roles in marine carbon and nitrogen cycles by fixing inorganic carbon and performing the initial step of nitrification. Evaluation of carbon and nitrogen metabolism popularly relies on functional genes such as amoA and accA. Increasing studies suggest that quorum sensing (QS) mainly studied in biofilms for bacteria may serve as a universal communication and regulation mechanism among prokaryotes; however, this has yet to be demonstrated in marine planktonic archaea. To bridge this knowledge gap, we employed a combination of metabolic activity markers (amoA, accA, and grs) to elucidate the regulation of AOA-mediated nitrogen and carbon processes, including their interactions with the surrounding heterotrophic population. Through co-transcription investigations linking metabolic markers to potential key QS genes, we discovered that QS molecules could regulate AOA's carbon, nitrogen, and lipid metabolisms under different conditions. Interestingly, specific AOA ecotypes showed a preference for employing distinct QS systems and a distinct QS circuit involving typical population. Overall, our data demonstrate that quorum sensing (QS) orchestrates nitrogen and carbon metabolism, including the exchange of organic metabolites between AOA and surrounding heterotrophic bacteria, which has been previously overlooked in marine AOA research.

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“…In addition to AHLs, acidophiles have enzyme systems encoding second messenger cyclic di-guanosine (c-di-GMP) that assist in regulating the QS system [ 41 ]. Huang et al revealed the presence of AHL, autoinducer-3, DSF, and AHL-degrading enzymes by annotating the genome of 83 species of acidophiles [ 42 ]. Bioinformatics prediction and laboratory experiments have identified the QS system in acidophiles.…”

Section: Introductionmentioning

confidence: 99%

Roles and Regulation of Quorum Sensing of Acidophiles in Bioleaching: A Review

Luo,

Li,

Chen

et al. 2024

Microorganisms

Self Cite

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Bioleaching has gained significant attention as a cost-effective and environmentally friendly approach for extracting metals from low-grade ores and industrial byproducts. The application of acidophiles in bioleaching has been extensively studied. Among the various mechanisms leaching microorganisms utilize, quorum sensing (QS) is pivotal in regulating their life activities in response to population density. QS has been confirmed to regulate bioleaching, including cell morphology, community structure, biofilm formation, and cell metabolism. Potential applications of QS have also been proposed, such as increasing mineral leaching rates by adding signaling molecules. This review is helpful for comprehensively understanding the role of QS in bioleaching and promoting the practical application of QS-based strategies in bioleaching process optimization.

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Insights into Adaptive Mechanisms of Extreme Acidophiles Based on Quorum Sensing/Quenching-Related Proteins

Abstract: Understanding cell-cell communication QS is highly relevant for comprehending the regulatory and adaptive mechanisms among acidophiles in extremely acidic ecosystems. Previous studies focused on the existence and functionality of a single QS system in several acidophilic strains.

Cited by 7 publications

References 68 publications

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

A growing battlefield in the war against biofilm-induced antimicrobial resistance: insights from reviews on antibiotic resistance

Metabolic activities of marine ammonia-oxidizing archaea orchestrated by quorum sensing

Roles and Regulation of Quorum Sensing of Acidophiles in Bioleaching: A Review

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