Insight on Serum Albumin: From Structure and Biological Properties to Functional Biomaterials for Bone Repair

Jin, Mengmeng; Hou, Yi

doi:10.1021/acsbiomaterials.2c01553

Cited by 8 publications

(3 citation statements)

References 133 publications

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“…Serum albumin (SA), with a molecular weight of 66.5 kDa, is the most abundant protein found in the bloodstream 115 . It possesses a remarkable systemic circulation time of approximately 19 days 116 .…”

Section: Cell/protein Choices For In Vivo Hitchhikingmentioning

confidence: 99%

Advanced hitchhiking nanomaterials for biomedical applications

Wang,

Sun,

Liu

et al. 2023

Theranostics

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Hitchhiking, a recently developed bio-inspired cargo delivery system, has been harnessed for diverse applications. By leveraging the interactions between nanoparticles and circulatory cells or proteins, hitchhiking enables efficient navigation through the vasculature while evading immune system clearance. Moreover, it allows for targeted delivery of nutrients to tissues, surveillance of the immune system, and pathogen elimination. Various synthetic nanomaterials have been developed to facilitate hitchhiking with circulatory cells or proteins. By combining the advantages of synthetic nanomaterials and circulatory cells or proteins, hitchhiking nanomaterials demonstrate several advantages over conventional vectors, including enhanced circulatory stability and optimized therapeutic efficacy. This review provides an overview of general strategies for hitchhiking, choices of cells and proteins, and recent advances of hitchhiking nanomaterials for biomedical applications.

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Section: Cell/protein Choices For In Vivo Hitchhikingmentioning

confidence: 99%

Advanced hitchhiking nanomaterials for biomedical applications

Wang,

Sun,

Liu

et al. 2023

Theranostics

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“…According to previous studies, albumin is successfully used as a biostatic structure, biomaterial coating, or highly biocompatible scaffold [32,33,[40][41][42][43]. Tissue-engineered serum albumin hydrogels used as scaffolds offer a porous structure to achieve great fluid permeability and effective nutrition flow to provide better tissue regeneration [44]. Such scaffolds could be utilized in numerous clinical applications that require grafting materials that promote superior healing processes [45].…”

Section: Introductionmentioning

confidence: 99%

“…Such scaffolds could be utilized in numerous clinical applications that require grafting materials that promote superior healing processes [45]. Furthermore, albumin is an active molecule; the mode of action is not yet fully clarified, but previous animal and in vitro studies have shown that after bone fractures, the local albumin concentration increases [44,46]. Even twelve months after albumin-coated bone allograft implantations, intensive osteoblast action can be observed [47].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases

Gyulay,

Karászi,

Rédei

et al. 2023

IJMS

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We have previously reported that serum albumin-coated bone allograft (BoneAlbumin, BA) is an effective bone substitute. It improves bone regeneration at the patellar and tibial donor sites six months after harvesting bone-patellar tendon-bone (BPTB) autografts for primary anterior cruciate ligament reconstruction (ACLR). In the present study, we examined these donor sites seven years after implantation. The study group (N = 10) received BA-enhanced autologous cancellous bone at the tibial and BA alone at the patellar site. The control group (N = 16) received autologous cancellous bone at the tibial and blood clot at the patellar site. We evaluated subcortical density, cortical thickness, and bone defect volume via CT scans. At the patellar site, subcortical density was significantly higher in the BA group at both time points. There was no significant difference in cortical thickness between the two groups at either donor site. The control group’s bone defect significantly improved and reached the BA group’s values at both sites by year seven. Meanwhile, the bone defects in the BA group did not change significantly and were comparable to the six-month measurements. No complications were observed. There are two limitations in this study: The number of patients recruited is small, and the randomization of the patients could have improved the quality of the study as the control group patients were older compared to the study group patients. Our 7-year results seem to demonstrate that BA is a safe and effective bone substitute that supports faster regeneration of donor sites and results in good-quality bone tissue at the time of ACLR with BPTB autografts. However, studies with a larger number of patients are required to definitively confirm the preliminary results of our study.

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Circular dichroism spectrum of (R)‐(+)‐3,3′‐dibromo‐1,1′‐bi‐2‐naphthol in albumin: Alterations caused by complexation—Experimental and in silico investigation

Ximenes,

Yoguim,

de Souza

et al. 2024

Chirality

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This study describes the interaction of human serum albumin (HSA) with the binol derivative (R)‐(+)‐3,3′‐dibromo‐1,1′‐bi‐2‐naphthol (R‐BrB), which has its optical activity based on the prohibitive energetic barrier for conversion into the enantiomer (S)‐(+)‐3,3′‐dibromo‐1,1′‐bi‐2‐naphthol (S‐BrB). The objective was to assess the ability of HSA to differentiate axial enantiomers based on their binding efficiency and their impact on the CD spectra. We discovered that both enantiomers were effective ligands, and the CD signal disappeared when equimolar amounts of R‐BrB and S‐BrB were simultaneously added, indicating no preference for either enantiomer. The complexation resulted in a significant signal increase at 250 nm and a bathochromic effect at 370 nm. Molecular docking simulations were performed, and the lower energy pose of R‐BrB was selected for DFT calculations. The theoretical CD spectra of free and complexed R‐BrB were obtained and showed alterations corroborating the experimental results. By comparing the difference spectrum (HSA:R‐BrB minus HSA) with the spectrum of free RBrB in water or ethyl alcohol, we concluded that the CD signal intensification was due to the increased solubilization of R‐BrB upon binding to HSA.

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Insight on Serum Albumin: From Structure and Biological Properties to Functional Biomaterials for Bone Repair

Cited by 8 publications

References 133 publications

Advanced hitchhiking nanomaterials for biomedical applications

Advanced hitchhiking nanomaterials for biomedical applications

Evaluation of Serum Albumin-Coated Bone Allograft for Bone Regeneration: A Seven-Year Follow-Up Study of 26 Cases

Circular dichroism spectrum of (R)‐(+)‐3,3′‐dibromo‐1,1′‐bi‐2‐naphthol in albumin: Alterations caused by complexation—Experimental and in silico investigation

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