Circular dichroism spectrum of (R)‐(+)‐3,3′‐dibromo‐1,1′‐bi‐2‐naphthol in albumin: Alterations caused by complexation—Experimental and in silico investigation
Valdecir Farias Ximenes,
Maurício Ikeda Yoguim,
Aguinaldo Robinson de Souza
et al.
Abstract:This study describes the interaction of human serum albumin (HSA) with the binol derivative (R)‐(+)‐3,3′‐dibromo‐1,1′‐bi‐2‐naphthol (R‐BrB), which has its optical activity based on the prohibitive energetic barrier for conversion into the enantiomer (S)‐(+)‐3,3′‐dibromo‐1,1′‐bi‐2‐naphthol (S‐BrB). The objective was to assess the ability of HSA to differentiate axial enantiomers based on their binding efficiency and their impact on the CD spectra. We discovered that both enantiomers were effective ligands, and … Show more
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