Insight into the role of myokines and myogenic regulatory factors under hypobaric hypoxia induced skeletal muscle loss

Srivastava, Sukanya; Rathor, Richa; Singh, Som Nath; Suryakumar, Geetha

doi:10.1080/1354750x.2022.2112290

Cited by 5 publications

(4 citation statements)

References 48 publications

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“…Hypobaric Hypoxia: The simulated high-altitude environment was provided to animals through an animal decompression chamber. [4][5][6][7]79] An altitude of 7620 m, 8% O 2 , and pressure at 282 torr, along with 23-25 °C temperature, 45-55% humidity, and airflow of 2 l min −1 was maintained inside the chamber for the hypoxic group. The decompression chamber or hypoxia chamber was opened once a day to measure the body weight of the animals, change the bedding, and refill the water and food supply.…”

Section: Methodsmentioning

confidence: 99%

“…[3][4][5][6] Recently, we have also reported skeletal muscle as an endocrine organ that secretes myokines and myogenic regulatory factors for the repair and regeneration of HH-induced skeletal muscle loss. [7] A regulatory structure that also regulates skeletal muscle mass is microRNA. Recently, muscle-specific microRNAs are called "myomiR" [8] which have emerged as one of the critical regulators of skeletal muscle function.…”

Section: Introductionmentioning

confidence: 99%

“…[ 3–6 ] Recently, we have also reported skeletal muscle as an endocrine organ that secretes myokines and myogenic regulatory factors for the repair and regeneration of HH‐induced skeletal muscle loss. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

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Increased Expression of MiRNA‐1 Contributes to Hypobaric Hypoxia‐Induced Skeletal Muscle Loss

Srivastava,

Mondal,

Rathor

et al. 2023

Advanced Biology

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The present study aims to analyze the role of microRNA‐1 in the regulation of skeletal muscle loss under hypobaric hypoxia (HH). Male Sprague Dawley rats (n = 10) weighing 230–250 g are divided into two groups, control and HH exposure for 7 days at 25 000 ft. After the hypoxia exposure, the animals are sacrificed and hindlimb skeletal muscles are excised for further analysis. Studies found the potential role of miR‐1 (myomiR) as a biomarker under different atrophic conditions. Prolonged exposure to HH leads to enhanced expression of miR‐1 in skeletal muscle as compared to unexposed controls. The Bioinformatics approach is used to identify the validated targets and the biological processes of miR‐1. The target prediction tools identify PAX3 and HSP70 as major targets for miR‐1. Exposure to HH significantly reduces PAX3 and HSP70 expression during 7 days of HH exposure, which further enhances the activity of FOXO3, MSTN, and ATROGIN known for the progression of skeletal muscle atrophy in relation to control rats. This study indicates the increased expressions of miR‐1 and reduced expression of PAX3 and HSP70 lead to impaired myogenesis in skeletal muscle under HH. Further, enhanced expression of muscle degradation genes such as FOXO3, MSTN, and ATROGIN under HH exposure causes skeletal muscle protein loss.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Increased Expression of MiRNA‐1 Contributes to Hypobaric Hypoxia‐Induced Skeletal Muscle Loss

Srivastava,

Mondal,

Rathor

et al. 2023

Advanced Biology

Self Cite

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“…Associated mechanisms may include elevated neural precursor cell expressed developmentally down-regulated protein (NEDD)4 expression in muscle ( 42 ) and transforming growth factor (TGF)-mediated MSTN ( 43 ). Nevertheless, there are contrasting hypotheses that a high CO 2 environment can promote MSTN degradation by activating the AMPKα2-forkhead box O-like (FoxO) 3a-MuRF1 pathway ( 44 , 45 ). Studies on the mechanisms of COPD combined with sarcopenia have shown high heterogeneity in the fields of hypoxia and oxidative stress; however, the sample sizes of the relevant clinical studies are relatively small.…”

Section: Pathogenesismentioning

confidence: 99%

Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia

et al. 2023

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Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases in the elderly population and is characterized by persistent respiratory symptoms and airflow obstruction. During COPD progression, a variety of pulmonary and extrapulmonary complications develop, with sarcopenia being one of the most common extrapulmonary complications. Factors that contribute to the pathogenesis of coexisting COPD and sarcopenia include systemic inflammation, hypoxia, hypercapnia, oxidative stress, protein metabolic imbalance, and myocyte mitochondrial dysfunction. These factors, individually or in concert, affect muscle function, resulting in decreased muscle mass and strength. The occurrence of sarcopenia severely affects the quality of life of patients with COPD, resulting in increased readmission rates, longer hospital admission, and higher mortality. In recent years, studies have found that oral supplementation with protein, micronutrients, fat, or a combination of nutritional supplements can improve the muscle strength and physical performance of these patients; some studies have also elucidated the possible underlying mechanisms. This review aimed to elucidate the role of nutrition among patients with coexisting COPD and sarcopenia.

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Myokines: A central point in managing redox homeostasis and quality of life

Rathor,

Suryakumar

2024

BioFactors

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Redox homeostasis is a crucial phenomenon that is obligatory for maintaining the healthy status of cells. However, the loss of redox homeostasis may lead to numerous diseases that ultimately result in a compromised quality of life. Skeletal muscle is an endocrine organ that secretes hundreds of myokines. Myokines are peptides and cytokines produced and released by muscle fibers. Skeletal muscle secreted myokines act as a robust modulator for regulating cellular metabolism and redox homeostasis which play a prime role in managing and improving metabolic function in multiple organs. Further, the secretory myokines maintain redox homeostasis not only in muscles but also in other organs of the body via stabilizing oxidants and antioxidant levels. Myokines are also engaged in maintaining mitochondrial dynamics as mitochondria is a central point for the generation of reactive oxygen species (ROS). Ergo, myokines also act as a central player in communicating signals to other organs, including the pancreas, gut, liver, bone, adipose tissue, brain, and skin via their autocrine, paracrine, or endocrine effects. The present review provides a comprehensive overview of skeletal muscle‐secreted myokines in managing redox homeostasis and quality of life. Additionally, probable strategies will be discussed that provide a solution for a better quality of life.

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Insight into the role of myokines and myogenic regulatory factors under hypobaric hypoxia induced skeletal muscle loss

Cited by 5 publications

References 48 publications

Increased Expression of MiRNA‐1 Contributes to Hypobaric Hypoxia‐Induced Skeletal Muscle Loss

Increased Expression of MiRNA‐1 Contributes to Hypobaric Hypoxia‐Induced Skeletal Muscle Loss

Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia

Myokines: A central point in managing redox homeostasis and quality of life

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