Insight into the role of a novel c-di-GMP effector protein in Rhodococcus ruber

Yuan, Yuan; Zhang, Fan; Ai, Lei; Huang, Yuzhu; Ren, Ping

doi:10.1016/j.bbrc.2022.03.131

Cited by 2 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether and how pollutants might interfere with signal perception and downstream cyclic di‐GMP signaling to potentially disturb these or other delicate ecological interactions remains to be shown. On the other hand, cyclic di‐GMP signaling might be exploited for enhanced performance of microbial strains and communities for the biodegradation of pollutants and in wastewater treatment processes partly also due to the enhanced tolerance, degradation potential, and stabilized biofilm formation mediated by cyclic di‐GMP signaling (Benedetti et al, 2016; Dorado‐Morales et al, 2021; Schmutzler et al, 2017; Wan et al, 2016; Wang & Shao, 2021; Yuan et al, 2022).…”

Section: Impact Of Cyclic Di‐gmp Signaling In the Ecological Agricult...mentioning

confidence: 99%

Cyclic di‐GMP signaling—Where did you come from and where will you go?

Römling

2023

Molecular Microbiology

View full text Add to dashboard Cite

Microbes including bacteria are required to respond to their often continuously changing ecological niches in order to survive. While many signaling molecules are produced as seemingly circumstantial byproducts of common biochemical reactions, there are a few second messenger signaling systems such as the ubiquitous cyclic di‐GMP second messenger system that arise through the synthesis of dedicated multidomain enzymes triggered by multiple diverse external and internal signals. Being one of the most numerous and widespread signaling system in bacteria, cyclic di‐GMP signaling contributes to adjust physiological and metabolic responses in all available ecological niches. Those niches range from deep‐sea and hydrothermal springs to the intracellular environment in human immune cells such as macrophages. This outmost adaptability is possible by the modularity of the cyclic di‐GMP turnover proteins which enables coupling of enzymatic activity to the diversity of sensory domains and the flexibility in cyclic di‐GMP binding sites. Nevertheless, commonly regulated fundamental microbial behavior include biofilm formation, motility, and acute and chronic virulence. The dedicated domains carrying out the enzymatic activity indicate an early evolutionary origin and diversification of “bona fide” second messengers such as cyclic di‐GMP which is estimated to have been present in the last universal common ancestor of archaea and bacteria and maintained in the bacterial kingdom until today. This perspective article addresses aspects of our current view on the cyclic di‐GMP signaling system and points to knowledge gaps that still await answers.

show abstract

Section: Impact Of Cyclic Di‐gmp Signaling In the Ecological Agricult...mentioning

confidence: 99%

Cyclic di‐GMP signaling—Where did you come from and where will you go?

Römling

2023

Molecular Microbiology

View full text Add to dashboard Cite

show abstract

An Overview of the Role of Membrane Proteins in Microbial Solvents Tolerance

Mei

Ren

2023

PPL

View full text Add to dashboard Cite

Background: Solvent tolerance is a desired feature of microorganisms for their application in biotechnology. Organic solvent-tolerant microorganisms are able to thrive in the presence of organic solvents. Several mechanisms have been proposed to elucidate their intrinsic tolerance to organic solvents. Objective: The present review aims to summarize the state of the art of the roles of membrane proteins in microbial organic solvent tolerance. Strategies and challenges for improving the protective function of membrane proteins in organic solvent stress are also proposed. Results: Membrane proteins related to transporter, signal transduction, and material and energy metabolism are involved in solvent tolerance. Optimization of the expression level of membrane proteins and engineering of membrane proteins are utilized to tackle the toxicity caused by organic solvents. Conclusions: Membrane proteins occupy a strikingly important position in microbial solvent tolerance. Further research on novel methods in membrane proteins, trade-offs among overexpression and toxicity of membrane proteins and solvent yield, and a direct relationship between signaling pathways and solvent tolerance will advance the utilization of organic solvent-tolerant microorganisms in biotechnology.

show abstract

Insight into the role of a novel c-di-GMP effector protein in Rhodococcus ruber

Cited by 2 publications

References 27 publications

Cyclic di‐GMP signaling—Where did you come from and where will you go?

Cyclic di‐GMP signaling—Where did you come from and where will you go?

An Overview of the Role of Membrane Proteins in Microbial Solvents Tolerance

Contact Info

Product

Resources

About