Insight into the Role of Angiopoietins in Ageing-Associated Diseases

Abstract

Angiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is expected to permit clinical applications, especially in antiangiogenic therapies against tumors. Several drugs targeting the Ang-TIE signaling pathway in cancer patients are under clinical development. Similar to how cancer increases with age, unsuitable angiogenesis or endothelial dysfunction is often seen in other ageing-associated diseases (AADs) such as atherosclerosis, Alzheimer’s disease, type 2 diabetes, chronic kidney disease and cardiovascular diseases. Thus, the Ang-TIE pathway is a possible molecular target for AAD therapy. In this review, we focus on the potential role of the Ang-TIE signaling pathway in AADs, especially non-cancer-related AADs. We also suggest translational insights and future clinical applications of this pathway in those AADs.

The Potential Role of Cytokines and Growth Factors in the Pathogenesis of Alzheimer’s Disease

“…Dysfunction of autophagy/mitophagy indicates a notable neuroinflammatory pathology and involvement of cytokines. IL-1β and IFN-γ (which are known to be expressed in AD pathogenesis) exposure to primary rat β-islet cells hindered autophagy resulting in cell apoptosis [64] and additionally, IL-1β was reported to modulate microglia autophagy in LPS cultures in the presence and absence of Aβ42 [67,86]. This evidence suggests that IL-1β and IFN-γ maintain control of inflammation in AD via lysosomal pathway and initiation of phagophore assembly.…”

scAgeCom: a murine atlas of age-related changes in intercellular communication inferred with the package scDiffCom

“…This LRI could be an important regulator of microvascular aging and its therapeutic potential seems worth investigating. Moreover, we found down-regulation of angiopoietin-1 (Angpt1) in 7 tissues, which could lead to the formation of leaky vessels, as vessel stability relies on the balance of Angpt1 and Angpt2 81 .…”

Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway

“…The development of RA disease relies upon pannus formation and neovascularization ( 2 ). Ang1 is a critical modulator during the physiological and pathological progression of angiogenesis ( 39 ). APLN reportedly increases IL-1β expression and VEGF-mediated angiogenesis, facilitating OA development ( 14 , 19 ).…”