Insight into the effect of particle size distribution differences on the antibacterial activity of carbon dots

Sun, Baohong; Wu, Fan; Zhang, Qicheng; Chu, Xiaohong; Wang, Zhixuan; Huang, Xinrong; Li, Jie; Yang, Cheng; Zhou, Ninglin; Shen, Jian

doi:10.1016/j.jcis.2020.10.015

Cited by 80 publications

(76 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, K. pneumoniae and S. epidermidis were displaying a much higher incubation time for the complete eradication. In comparison to other heteroatom doped CDs reported in the literature [48][49][50], our synthesized CDs exhibited superior antimicrobial effects against all four pathogens without any passivation of atoms. Two major compounds, demethoxycurcumin and bisdemethoxycurcumin, are partially remained inside or on the surface of CDs, which enhance the bactericidal property of CDs.…”

Section: Antibacterial Activitymentioning

confidence: 62%

Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

et al. 2021

View full text Add to dashboard Cite

Carbon dots (CDs) were obtained from medicinal turmeric leaves (Curcuma longa) by a facile one-step hydrothermal method and evaluated for their bactericidal activities against two gram-negative; Escherichia coli, Klebsiella pneumoniae, and two gram-positive counterparts; Staphylococcus aureus, S. epidermidis. The CDs exhibited spherical shapes with a mean size of 2.6 nm. The fluorescence spectra of CDs revealed intense fluorescence at λex/em = 362/429 nm with a bright blue color in an aqueous solution. The CDs showed strong photostability under various environmental conditions (pH, salt, and UV-radiation). The complete bactericidal potency of CDs was 0.25 mg/mL for E.coli and S. aureus after 8 h of exposure, while for K. pneumoniae, and S. epidermidis, the CDs at 0.5 mg/mL good antibacterial effect within 8 h and complete eradication after 24 h of exposure is observed. The release of reactive oxygen species played a crucial role in the death of the bacterial cell. The present study provides a strategy for the preparation of CDs from a medicinal plant and their potential antibacterial activities against four common contagious pathogens.

show abstract

Section: Antibacterial Activitymentioning

confidence: 62%

Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Both drug-resistant and toxic problems are relieving [ 8 ]. Recently, CDs [ 9 , 10 ] and nanoclusters (NCs) [ 11 ] are well applied for combating bacterial infections because they are biocompatible [ 12 ], active [ 13 ], and can be easily cleaned by circulations due to the ultra-small sizes [ 14 , 15 ]. Especially, researchers have found that CDs show excellent free radical scavenging ability, which can be stronger than many traditional anti-infection drugs [ 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Zhuang

Li²,

Daoyong³

et al. 2021

Nanoscale Res Lett

View full text Add to dashboard Cite

Carbon dots (CDs) have been widely used as antimicrobials due to their active surface, but some CDs suffer instability. Therefore, the relative applications such as the antibacterial activity may not be reliable for long-term use. Herein, we synthesize CDs with blue fluorescence by a hydrothermal process. Thereafter, polyethylenimine was applied for the assembly of CDs into CDs-based frameworks (CDFs). The CDFs exhibited quenched fluorescence but showed more stable properties based on the scanning electron microscope and zeta potential investigations. Both CDs and CDFs show antibacterial activity toward Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), but CDFs exhibited better antibacterial performance, and S. aureus could be completely inhibited with the minimum inhibitory concentration of 30 μg/mL. This reveals CDFs magnify both the stability and antibacterial activity, which would be more promising for practical applications. Graphic abstract

show abstract

“…These results revealed that CGCDs lead to frustration in the walls and membranes of E. coli and S. aureus. Bacterial death can be controlled by tuning the size of the CGCDs [76]. Ma et al tested three kinds of CDs, including osmanthus leaves-derived CDs (OCDs), milk vetch-derived CDs (MCDs), and tea leaves-derived CDs (TCDs).…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Magnified SEM images in the red square (b) E. coli, (f) S. aureus; and ACDs-treated (d) E. coli, and (h) S. aureus, adapted with permission from[123], Royal Society of Chemistry, 2020. SEM images of (i) E. coli and S. aureus untreated and treated with 75 µg/mL and 50 µg/mL of s-CGCDs, m-CGCDs, and l-CGCDs in Luria-Bertani broth medium for 6 h, adapted with permission from[76], Elsevier, 2021.…”

mentioning

confidence: 99%

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

View full text Add to dashboard Cite

This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.

show abstract

Insight into the effect of particle size distribution differences on the antibacterial activity of carbon dots

Cited by 80 publications

References 86 publications

Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

Green Synthesis of Multifunctional Carbon Dots with Antibacterial Activities

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

Contact Info

Product

Resources

About