Insight into prognostics, diagnostics, and management strategies for SARS CoV-2

Abstract

The foremost challenge in countering infectious diseases is the shortage of effective therapeutics.

Nanotechnology meets immunology towards a rapid diagnosis solution: the COVID-19 outbreak challenge

“…Thus, based on these results, it is worth mentioning that, compared to other similar assays reported in the literature for COVID-19 rapid diagnosis, 12 our newly developed LFA test presents a reliable rapid qualitative color reading detection response within 10 minutes after applying the sample, which endows applicability at the point-of-care by individuals in general and health professionals. Although beyond the scope of this research, it can be envisioned that further studies will need to address other parameters, including the limit of detection, sensitivity, and accuracy for the specificity of detection of COVID-19, where other viruses that could potentially cause cross-reactions, would be discarded ( e.g.…”

“…Since the very beginning of the SARS-CoV-2 reported cases, it was almost a consensus among health professionals, public authorities, and society that the strategy to fight the pandemic would require different crucial fronts, including (i) social distancing and sanitary actions combined with rapid and early diagnosis of infected individuals to minimize or ideally to avoid the virus dissemination; (ii) intensive research for developing new vaccines preventing the infection through massive vaccination, and (iii) dramatic search for effective treatments for the infected patients to reduce hospitalization and mortality. 9–14…”

“…[6][7][8] Since the very beginning of the SARS-CoV-2 reported cases, it was almost a consensus among health professionals, public authorities, and society that the strategy to ght the pandemic would require different crucial fronts, including (i) social distancing and sanitary actions combined with rapid and early diagnosis of infected individuals to minimize or ideally to avoid the virus dissemination; (ii) intensive research for developing new vaccines preventing the infection through massive vaccination, and (iii) dramatic search for effective treatments for the infected patients to reduce hospitalization and mortality. [9][10][11][12][13][14] In this view, from the strategic diagnosis front against COVID-19, most health facilities rely on polymerase chain reaction (PCR)-based tests based on the amplication of genetic material (i.e., RNA) to detect the virus. While considered the "gold standard" method for diagnosis and extremely sensitive, PCR poses several challenges, including a relatively long time to get the results, a "cold chain" is usually required to transport the samples from patients to the lab, sophisticated facilities and expensive equipment are needed, and well-trained lab technicians are essential to perform the testing.…”

The role of electrochemical biosensors in SARS-CoV-2 detection: a bibliometrics-based analysis and review

“…7 Developing an accurate and efficient SARS-CoV-2 detection method is essential to reducing the rate of COVID-19 transmission. [8][9][10] In the past two years, many papers have proposed new methods to detect SARS-CoV-2.…”

2D MXene‐Based Biosensing: A Review

“…The outburst of the coronavirus disease (COVID-19) has caused a great menace to human health and well-being. [1,2] The main challenge in countering this infectious disease was the absence of effective therapeutics. It put forth the importance of early disease monitoring of chronic pathologies that aid to reduce mortality and improve patient healthcare.…”