Insight into drug sensitizing effect of diallyl disulfide and diallyl trisulfide from Allium sativum L. on paclitaxel-resistant triple-negative breast cancer cells

Marni, Rakshmitha; Kundrapu, Durga Bhavani; Chakraborti, Anindita; Malla, Rama Rao

doi:10.1016/j.jep.2022.115452

Cited by 17 publications

(10 citation statements)

References 81 publications

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“…The incubation of PTX‐resistant TNBC cells with diallyl disulfide (DADs) and DATS induced cell cycle arrest and cell death by generating ROS and activating caspase 3 and 9 via targeting CD151. Hence, DADs and DATS from Allium sativum L. have the anticancer potential to treat paclitaxel‐resistant breast cancers (Marni et al, 2022). Curcumin found in turmeric , prevented NK‐B activation in the nucleus.…”

Section: Natural Compounds Inhibiting Tnbcmentioning

confidence: 99%

Compounds from diverse natural origin against triple‐negative breast cancer: A comprehensive review

et al. 2022

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Triple‐negative breast cancer (TNBC) is caused due to the lack of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor 2 (HER2) expression. Triple‐negative breast cancer is the most aggressive heterogeneous disease that is capable of producing different clones and mutations. Tumorigenesis in TNBC is caused due to the mutation or overexpression of tumor suppressor genes. It is also associated with mutations in the BRCA gene which is linked to hereditary breast cancer. In addition, PARP proteins and checkpoint proteins also play a crucial function in causing TNBC. Many cell signaling pathways are dysregulated in TNBC. Even though chemotherapy and immunotherapy are good options for TNBC treatment, the response rates are still low in general. Many phytochemicals that are derived from natural compounds have shown very good inhibitions for TNBC. Natural compounds have the great advantage of being less toxic, having lesser side effects, and being easily available. The secondary metabolites such as alkaloids, terpenoids, steroids, and flavonoids in natural products make them promising inhibitors of TNBC. Their compositions also offer vital insights into inhibitory action, which could lead to new cancer‐fighting strategies. This review can help in understanding how naturally occurring substances and medicinal herbs decrease specific tumors and pave the way for the development of novel and extremely efficient antitumor therapies.

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Section: Natural Compounds Inhibiting Tnbcmentioning

confidence: 99%

Compounds from diverse natural origin against triple‐negative breast cancer: A comprehensive review

et al. 2022

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“…17 DATS, as the most abundant component in garlic oil, has been attributed to many biological effects. Studies have shown that DATS can protect against inflammation and oxidative stress induced by doxorubicin, 19 alleviate cisplatin-induced oxidative injuries, 20 trigger apoptosis in cancer cells, 21 and even overcome drug resistance in breast cancer. 22 Given the significant presence and potential beneficial effects of DATS in garlic oil, it is essential to investigate whether DATS also possesses preventive properties against lung tumorigenesis stimulated by tobacco carcinogens.…”

Section: Introductionmentioning

confidence: 99%

Diallyl trisulfide inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer via modulating gut microbiota and the PPARγ/NF-κB pathway

Qu,

Tian,

Sun

et al. 2024

Food Funct.

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“…The presence of organosulfur compounds, such as S-allyl cysteine sulfoxide (alliin), diallythiosulfinate (allicin), diallyl disulfide (DADS), S-propyl cysteine sulfoxide (PCSO) and Smethyl cysteine sulfoxide (MCSO) is thought to confer garlic with [1] cancer preventive [3] and therapeutic potential [4]. Many of these active substances have also been studied for their individual effects on cancer cells [5]. For example, alliin induces apoptosis via the generation of reactive oxygen species (ROS) in gastric carcinoma cells [6].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative efficacy and mechanism of action of garlic phytochemicals-functionalized gold nanoparticles in triple-negative breast cancer cells

Meher,

Paithankar,

Hosur

et al. 2024

Biomed. Mater.

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Fabrication of gold nanoparticles (GNPs) with phytochemicals is an emerging green nanotechnology approach with therapeutic implications. Garlic, known for its culinary and medicinal properties, has been extensively investigated for its anticancer properties. Here, we report a method to substantially enhance the antiproliferative potency of garlic by functionalizing its phytochemicals to GNPs and demonstrate a possible mechanism of action of these nanoparticles in the triple-negative breast cancer cell line, MDA-MB-231. Garlic gold nanoparticles (As-GNPs) were synthesized using garlic extract (As-EX) and gold chloride and characterized using a variety of spectroscopy techniques, and transmission electron microscopy (TEM). Compared to As-EX, which has a negligible effect on the viability of the cells, As-GNPs inhibited cell viability with an IC50 of 0.310 ± 0.04 mg ml−1 and strongly inhibited the clonogenic and migratory propensities of these cells. As indicated by TEM, the As-GNPs entered the cells via endocytosis and dispersed in the cellular milieu. Since tubulin, the protein involved in cell division, is a verified target for several antiproliferative drugs, we next examined whether the As-GNPs interact with this protein. The As-GNPs showed concentration-dependent binding to purified tubulin, slightly but consistently perturbing its secondary helical integritywithout grossly damaging the tertiary structure of the protein or the net polymer mass of the microtubules, as indicated by a tryptophan-quenching assay, far UV-circular dichroism spectroscopy, anilinonaphthalene sulfonate-binding assay, and polymer mass analysis, respectively. In cells, As-GNPs killed the cancer cells without cell cycle arrest, as evidenced by flow cytometry.

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Insight into drug sensitizing effect of diallyl disulfide and diallyl trisulfide from Allium sativum L. on paclitaxel-resistant triple-negative breast cancer cells

Cited by 17 publications

References 81 publications

Compounds from diverse natural origin against triple‐negative breast cancer: A comprehensive review

Compounds from diverse natural origin against triple‐negative breast cancer: A comprehensive review

Diallyl trisulfide inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer via modulating gut microbiota and the PPARγ/NF-κB pathway

Antiproliferative efficacy and mechanism of action of garlic phytochemicals-functionalized gold nanoparticles in triple-negative breast cancer cells

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