Insecticides induced stress response and recuperation in fish: Biomarkers in blood and tissues related to oxidative damage

Narra, Madhusudan Reddy; Rajender, Kodimyala; Reddy, R. Rudra; Murty, Upadhyayula Suryanarayana; Begum, Ghousia

doi:10.1016/j.chemosphere.2016.10.066

Cited by 106 publications

(36 citation statements)

References 44 publications

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“…Similar results have also been reported (Adejumo et al, 2015). The increased levels of urea and creatinine in cockerels might be due to abnormal mechanisms of filtration and injury to kidneys (El-Murr et al, 2015;Narra et al, 2017). The quantity of serum cholesterol, cardiac isoenzyme and triglycerides increased in glyphosate treated cockerels.…”

Section: Discussionsupporting

confidence: 78%

Exposure to Sub-Acute Concentrations of Glyphosate Induce Clinico-Hematological, Serum Biochemical and Genotoxic Damage in Adult Cockerels

Hussain¹

2019

PVJ

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Current experimental study was aimed to find out the clinico-hematological, serum biochemical and DNA damage impacts of commonly used herbicide (glyphosate) on non-target adult cockerels. Therefore, a total of 25 cockerels were randomly placed in wire cages in five different groups each containing five birds. After seven days of acclimatization, glyphosate-based herbicide was administered to cockerels of groups (B-E) @ 50, 75, 100 and 125 mg/kg BW respectively except group A (control) for 45 days. Blood and serum was collected at 15, 30 and 45 day of the trial from each cockerel. The treated birds at higher doses indicated different clinical signs such as ruffled feather, dullness, tremors, anemic wattle and comb, depression and reduced frequency of crowing. Feed consumption and body mass was significantly (P≤0.05) lowered in cockerels exposed to higher doses of herbicide. The hematological parameters including red blood cell counts, hematocrit and hemoglobin was significantly lower in treated cockerels. Results on different biochemical parameters showed significantly lower quantity of total proteins and albumin while significantly higher concentrations of liver function tests (alanine aminotransferase, aspartate aminotransferase, alkaline phosphate), kidney function tests (urea and creatinine), cardiac biomarkers (CK-Mb, triglycerides, cholesterol) and oxidative stress parameter (malondialdehyde) of treated cockerels in dose and time dependent manner. Results indicate that the frequency of cells with tail DNA was significantly (P≤0.001) in exposed cockerels. The findings of the study suggested that long term exposure of glyphosate induces adverse clinicohematological, serum biochemical and genotoxic effects on birds. A, 2019. Exposure to sub-acute concentrations of glyphosate induce clinicohematological, serum biochemical and genotoxic damage in adult cockerels. Pak Vet J, 39(2): 181-186. http://dx.

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Section: Discussionsupporting

confidence: 78%

Exposure to Sub-Acute Concentrations of Glyphosate Induce Clinico-Hematological, Serum Biochemical and Genotoxic Damage in Adult Cockerels

Hussain¹

2019

PVJ

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“…Plasma glucose concentrations consistently dominate the first axis (i.e., the axis with the greatest explanatory power) of the RDA, independent of fish origin (resident, caged) or sex, and is mostly consistent between matrices (water only; sediment only; combined water and sediment). Increased plasma glucose concentrations as a result of pollutant stress have been noted in previous studies of pesticide exposure [ 103 , 104 ], estrogenic compound exposure [ 105 ] and whole effluent exposure [ 106 ]. The consistent opposition of plasma glucose concentration and relative gonad size (GSI) and gonad maturity along the first axis of the RDA suggests that increasing plasma glucose concentrations are inversely correlated with the reproductive potential of fish ( Fig 6 ; S10 and S11 Figs).…”

Section: Discussionmentioning

confidence: 83%

Contaminants of emerging concern in tributaries to the Laurentian Great Lakes: II. Biological consequences of exposure

et al. 2017

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The Laurentian Great Lakes contain one fifth of the world’s surface freshwater and have been impacted by human activity since the Industrial Revolution. In addition to legacy contaminants, nitrification and invasive species, this aquatic ecosystem is also the recipient of Contaminants of Emerging Concern (CECs) with poorly understood biological consequences. In the current study, we documented the presence, concentrations, and biological effects of CECs across 27 field sites in six Great Lakes tributaries by examining over 2250 resident and caged sunfish (Lepomis ssp.) for a variety of morphological and physiological endpoints and related these results to CEC occurrence. CEC were ubiquitous across studies sites and their presence and concentrations in water and sediment were highest in effluent dominated rivers and downstream of municipal wastewater treatment plant discharges. However, even putative upstream reference sites were not free of CEC presence and fish at these sites exhibited biological effects consistent with CEC exposure. Only the Fox River exhibited consistent adverse biological effects, including increased relative liver size, greater prominence of hepatocyte vacuoles and increased plasma glucose concentrations. Canonical Redundancy Analysis revealed consistent patterns of biological consequences of CEC exposure across all six tributaries. Increasing plasma glucose concentrations, likely as a result of pollutant-induced metabolic stress, were associated with increased relative liver size and greater prominence of hepatocyte vacuoles. These indicators of pollutant exposure were inversely correlated with indicators of reproductive potential including smaller gonad size and less mature gametes. The current study highlights the need for greater integration of chemical and biological studies and suggests that CECs in the Laurentian Great Lakes Basin may adversely affect the reproductive potential of exposed fish populations.

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“…Richendrfer et al [8] observed that Larvae treated with 0.1 mM (≈ 35.0mg/L) Chlorpyrifos had decreased more than 30% of levels of AChE. Recent researches showed that Chlorpyrifos could destroy oxygen free radical balance and form oxidative stress [3,11,12]. The GSH and GST as the important antioxidants substances in liver stressed by Chlorpyrifos were investigated extensively.…”

Section: Introductionmentioning

confidence: 99%

“…Chlorpyrifos (CPF) is widely used in agricultural production [1,2] and is sensitive to the fish [3][4][5][6]. Chlorpyrifos bond with cholinesterase by covalent [7,8] resulting in the accumulation of acetylcholine in the nervous system [8,9].…”

Section: Introductionmentioning

confidence: 99%

Effects of EGCG and Chlorpyrifos on the Mortality, AChE and GSH of Adult Zebrafish: Independent and Combination

Zhang

Gao

et al. 2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Insecticides induced stress response and recuperation in fish: Biomarkers in blood and tissues related to oxidative damage

Cited by 106 publications

References 44 publications

Exposure to Sub-Acute Concentrations of Glyphosate Induce Clinico-Hematological, Serum Biochemical and Genotoxic Damage in Adult Cockerels

Exposure to Sub-Acute Concentrations of Glyphosate Induce Clinico-Hematological, Serum Biochemical and Genotoxic Damage in Adult Cockerels

Contaminants of emerging concern in tributaries to the Laurentian Great Lakes: II. Biological consequences of exposure

Effects of EGCG and Chlorpyrifos on the Mortality, AChE and GSH of Adult Zebrafish: Independent and Combination

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