Insecticide Resistance and Vector Control

Brogdon, William G.; McAllister, Janet

doi:10.1300/j096v06n02_04

Cited by 94 publications

(110 citation statements)

References 63 publications

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“…Aedes mosquito control still challenges public health authorities of subtropical and tropical countries worldwide due to mosquito ability to adapt fast to adverse breeding conditions and also by the development of resistance against routinely used insecticides [7, 10, 12, 14, 27, 28]. Moreover, the capability of Aedes spp.…”

Section: Discussionmentioning

confidence: 99%

Knockdown resistance (kdr) of the voltage-gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia

et al. 2017

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Background Aedes aegypti is the main vector of several arthropod-borne viral infections in the tropics profoundly affecting humans, such as dengue fever (DF), West Nile (WN), chikungunya and more recently Zika. Eradication of Aedes still largely depends on insecticides, which is the most cost-effective strategy, and often inefficient due to resistance development in exposed Aedes populations. We here conducted a study of Ae. aegypti resistance towards several insecticides regularly used in the city of Denpasar, Bali, Indonesia.Methods Aedes aegypti egg samples were collected with ovitraps and thereafter hatched in the insectary of the Gadjah Mada University. The F0 generation was used for all bioassay-related experiments and knockdown resistance (kdr) assays.ResultsResults clearly showed resistance development of Ae. aegypti against tested insecticides. Mortalities of Ae. aegypti were less than 90% with highest resistance observed against 0.75% permethrin. Mosquitoes from the southern parts of Denpasar presented high level of resistance pattern in comparison to those from the western and northern parts of Denpasar. Kdr analysis of voltage-gated sodium channel (Vgsc) gene showed significant association to S989P and V1016G mutations linked to resistance phenotypes against 0.75% permethrin. Conversely, Ae. aegypti F1534C gene mutation did not result in any significant correlation to resistance development.ConclusionsPeriodically surveillance of insecticide resistances in Ae. aegypti mosquitoes will help local public health authorities to set better goals and allow proper evaluation of on-going mosquito control strategies. Initial detection of insecticide resistance will contribute to conduct proper actions in delaying mosquito resistance development such as insecticide rotation or combination of compounds in order to prolong chemical efficacy in combating Ae. aegypti vectors in Indonesia.

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Section: Discussionmentioning

confidence: 99%

Knockdown resistance (kdr) of the voltage-gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia

et al. 2017

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“…The mechanisms involved in insecticide resistance include three major groups of enzymes: esterases, mixed function oxidases (MFO) and glutathione S-transferases (GST), and alteration of target sites such as: insensitive acetylcholinesterase (iAChE) and kdr (knock down resistance) [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Susceptibility to insecticides and resistance mechanisms in Aedes aegypti from the Colombian Caribbean Region

Maestre‐Serrano¹,

Gómez‐Camargo²,

Ponce‐García³

et al. 2014

Pesticide Biochemistry and Physiology

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“…The major setback of insecticide use is the selection for resistance, observed not only in the targeted pests but also in many other sympatric species [2], [3]. At the physiological level, resistance is a consequence of either increased detoxication or modification of the insecticide target, the latter often resulting in very high insensitivity [4], [5]. However both mechanisms may be responsible for vector control failure and have to be addressed by insecticide resistance management strategies.…”

Section: Introductionmentioning

confidence: 99%

Novel AChE Inhibitors for Sustainable Insecticide Resistance Management

et al. 2012

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Resistance to insecticides has become a critical issue in pest management and it is particularly chronic in the control of human disease vectors. The gravity of this situation is being exacerbated since there has not been a new insecticide class produced for over twenty years. Reasoned strategies have been developed to limit resistance spread but have proven difficult to implement in the field. Here we propose a new conceptual strategy based on inhibitors that preferentially target mosquitoes already resistant to a currently used insecticide. Application of such inhibitors in rotation with the insecticide against which resistance has been selected initially is expected to restore vector control efficacy and reduce the odds of neo-resistance. We validated this strategy by screening for inhibitors of the G119S mutated acetylcholinesterase-1 (AChE1), which mediates insensitivity to the widely used organophosphates (OP) and carbamates (CX) insecticides. PyrimidineTrione Furan-substituted (PTF) compounds came out as best hits, acting biochemically as reversible and competitive inhibitors of mosquito AChE1 and preferentially inhibiting the mutated form, insensitive to OP and CX. PTF application in bioassays preferentially killed OP-resistant Culex pipiens and Anopheles gambiae larvae as a consequence of AChE1 inhibition. Modeling the evolution of frequencies of wild type and OP-insensitive AChE1 alleles in PTF-treated populations using the selectivity parameters estimated from bioassays predicts a rapid rise in the wild type allele frequency. This study identifies the first compound class that preferentially targets OP-resistant mosquitoes, thus restoring OP-susceptibility, which validates a new prospect of sustainable insecticide resistance management.

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Insecticide Resistance and Vector Control

Cited by 94 publications

References 63 publications

Knockdown resistance (kdr) of the voltage-gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia

Knockdown resistance (kdr) of the voltage-gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia

Susceptibility to insecticides and resistance mechanisms in Aedes aegypti from the Colombian Caribbean Region

Novel AChE Inhibitors for Sustainable Insecticide Resistance Management

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