Insect tea extract attenuates CCl4-induced hepatic damage through its antioxidant capacities in ICR mice

Abstract

The Insect tea extract (ITE) contained many polyphenols, the aim of the present study was to determine the preventive effects of ITE on CCl-induced hepatic damage in mice. ITE treated mice could reduce hepatic injury compared to the control mice. The 200 mg/kg ITE increased TC, ALB, SOD, CAT, GSH-Px serum levels, and decreased ALT, AST, ALP, TG, BUN, NO, MDA levels compared to the control group. By histological observation, ITE reduced injury to hepatic cells, and these effects were close to that seen with the drug silymarin. The antioxidant related mRNA and protein expressions of Mn SOD, Gu/Zn SOD, CAT, and GSH-Px increased with ITE treatment in hepatic damage mice. ITE treated mice also showed higher IκB-α mRNA and protein expression, and lower NF-κB-p65, iNOS, COX-2 expressions than those of control mice. These results proved ITE has a prophylactic effect in protecting against hepatic injury through the antioxidant capacities.

Lactobacillus fermentumHFY06 reduced CCl4-induced hepatic damage in Kunming mice

“…32 CCl 4 -induced liver injury can cause signicant intrahepatic inammation and liver brosis in mice. 4,15 Therefore, we used a CCl 4 -induced oxidative stress and acute liver injury mouse model to explore the protective effect of Lactobacillus fermentum HFY06 isolated from yak yogurt on liver injury. Liver weight and liver indices were used as indicators of CCl 4 -induced liver injury.…”

“…Therefore, the levels of serum cytokines, including IL-6, TNF-g and TNF-a, in patients with inammatory diseases are higher than those in healthy individuals. 4,15 Inammatory factors play important roles in liver function, and reducing these inammatory cytokines may be an improved method of preventing liver injury. 41 Previous studies have shown that probiotics can improve alcohol-induced liver injury through their own anti-inammatory properties.…”

“…NF-kB can promote COX-2 gene transcription and regulate its expression, thereby amplifying the inammatory response and aggravating liver injury. 14,15 Liver inammatory cells can produce superoxide, trigger oxidative stress, produce many reactive oxygen species, and damage cells, all of which can be regulated by several antioxidant-related genes. NF-kB, TNF-a and COX-2 mRNA expressions in the model group were higher than those in the normal group.…”

“…13 Increased secretion of genes such as nuclear factor-kB (NF-kB), TNF-a, cyclooxygenase-2 (COX-2) can damage and harm the liver causing inammatory. 4,14,15 Manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu/Zn-SOD) are SOD isomers in the body and are radical scavengers with different ions as active centers. SOD can inhibit free radicals in the body and prevent liver damage.…”

Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism

“…TPS can also improve the anti-oxidant function in gastric cancer mice via decreasing the levels of MDA and increasing the activity of antioxidant enzymes [78,112]. Tea extract could attenuate oxidative damage by improving the expression of SOD, CAT, and GPX, and downregulating the expression of iNOS and COX-2 in mice [113]. Further studies showed that EGCG inhibited iNOS gene expression, iNOS kinase and COX activities, which would reduce the generation of NO and prostacyclin, and decrease protein and DNA damage, and ultimately inhibit cancer [114,115].…”