Insect bite reaction and HIV infection

Nair, Sukumaran Pradeep

doi:10.4103/0378-6323.148612

Cited by 4 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present study is limited by its retrospective nature and small sample size; however, it supports findings reported by other authors and expands upon evidence for folliculocentric hypersensitivity reactions being a unique clinicopathologic entity 2,3,5,7,8 . Our cohort centered on the diagnosis of CLL/SLL, but it should be noted that similar cutaneous eruptions have been reported in various other hematologic malignancies, HIV, and agammaglobulinemia 18,19 . Further studies are warranted to determine whether there might be related pathogenesis between these entities.…”

Section: Discussionsupporting

confidence: 84%

Folliculocentric lymphocytic hypersensitivity reactions in CLL/SLL patients: A unique clinicopathologic entity amongst non‐specific hypersensitivity reactions

Abbott

Corean

Snyder

et al. 2023

Skin Health and Disease

View full text Add to dashboard Cite

Background Cutaneous hypersensitivity eruptions in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) are a clinically and histologically heterogeneous group that can either precede, occur with, or follow the development of a hematologic malignancy. Therefore, establishing the diagnosis requires careful clinical and pathologic correlation and an understanding of the broad spectrum of presentations. Data is lacking on the correlation of skin disease with molecular/cytogenetic risk profiling of the tumor. Objectives The aims of this study were to characterize the clinical, histological, and genetic aberrations in recurrent cutaneous hypersensitivity reactions in patients with CLL/SLL. Methods A single site academic retrospective chart review of medical records, histopathology, molecular and cytogenetic data in CLL/SLL patients who developed biopsy‐proven cutaneous hypersensitivity reactions. Results Five hundred one new diagnoses of CLL/SLL with 73 patients requiring cutaneous biopsies for skin lesions or rashes were identified. With exclusion criteria, 20 biopsies were identified from 17 patients (mean age, 69.6 years, females = 9) with unexplained cutaneous eruptions. These were commonly pruritic, erythematous papules above the waist. Most biopsies had a prominent superficial, deep dermal eosinophilic infiltrate (85%), with a robust T‐cell predominant dermal infiltrate in 40%. Five out of 17 patients (29%) had a predominately folliculocentric CD4+ T‐cell infiltrate; all occurring on the head and neck. Overall, the prevalence of cutaneous hypersensitivity eruptions requiring biopsy was 3.4% (n = 17), and the prevalence of folliculocentric CD4+ T‐cell infiltrate was 1% (n = 5). Conclusion Cutaneous hypersensitivity reactions in CLL/SLL are heterogeneous; however, folliculotropic CD4+ T‐cell infiltrates may be seen in a small but distinct clinical subset of patients. Commonly tested cytogenetic aberrations in CLL/SLL do not appear to be correlated with the presence of cutaneous hypersensitivity reactions.

show abstract

Section: Discussionsupporting

confidence: 84%

Folliculocentric lymphocytic hypersensitivity reactions in CLL/SLL patients: A unique clinicopathologic entity amongst non‐specific hypersensitivity reactions

Abbott

Corean

Snyder

et al. 2023

Skin Health and Disease

View full text Add to dashboard Cite

show abstract

“…Interestingly, “exaggerated insect bite reactions” have been described in patients positive for human immunodeficiency virus and patients with congenital agammaglobulinemia and have therefore been linked to the first description of Weed who coined this term in CLL patients . Having a closer look at these publications, however, in all these patients “true” insect bites are reported which clearly differentiates these conditions from ED. In contrast in ED, insect bites are no longer thought to be causative .…”

Section: Discussionmentioning

confidence: 99%

“…There is clinical evidence that the underlying malignancy is causative for ED because this reaction has not been described in nonmalignant conditions and healthy people . Interestingly, “exaggerated insect bite reactions” have been described in patients positive for human immunodeficiency virus and patients with congenital agammaglobulinemia and have therefore been linked to the first description of Weed who coined this term in CLL patients . Having a closer look at these publications, however, in all these patients “true” insect bites are reported which clearly differentiates these conditions from ED.…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic dermatosis of hematologic malignancy: Correlation of molecular characteristics of skin lesions and extracutaneous manifestations of hematologic malignancy

et al. 2018

View full text Add to dashboard Cite

Background Skin diseases are frequent in patients with chronic lymphocytic leukemia (CLL) and other hematological neoplasias. Eosinophilic dermatosis (ED) of hematologic malignancy has long been considered a nonspecific cutaneous reaction pattern. Recently neoplastic cells have been shown to be present in ED, thus challenging the classification as a nonspecific dermatosis. Methods We report five patients with ED in association with CLL. We further investigated the presence of neoplastic B‐cells in the skin infiltrate by immunohistochemistry and immunoglobulin heavy chain rearrangement and compared these to extracutaneous manifestations of CLL. Results The phenotype of the lymphocytic infiltrate was predominately CD3+ (range: 60%‐90%). CD20+ and CD79a+ lymphocytes were less frequent, accounting for up to 15% (range: absent ‐ 15%). CD23+ lymphocytes represented up to 20% (range: absent ‐ 20%) of the infiltrate. The analysis of the immunoglobulin heavy chain rearrangement in the skin specimens showed clonal rearrangements in 4/5 patients and in three of these four patients clones were identical to extracutaneous CLL manifestations. Conclusion Our data show that neoplastic B‐cells are very frequently found in ED when systematically evaluated. This findings support the hypothesis that leukemic cells play a pathogenetic role in ED of hematologic malignancy.

show abstract

“…Denominado de erupção pápulopruriginosa do HIV ou prurigo do HIV é considerado marcador da infecção HIV em algumas populações (172,173). Esta associado a níveis de CD4 inferior a 350 células por mm3 (162,(174)(175)(176), e também à falha terapêutica (177,178).…”

Section: 6 -Saliva Como Potencializadora De Doenças Sistêmicasunclassified

“…Fenômeno semelhante ocorreu com a erupção pápulo pruriginosa do HIV, também chamado de prurigo do HIV. Esta manifestação que é raramente descrita nas casuísticas dos países de clima temperado é considerada marcadora da infecção pelo HIV em algumas populações (172,173). Fator geográfico foi considerado como influenciador para o surgimento desta dermatose, que apresenta muitas semelhanças, do ponto de vista clínico e histológico com o a síndrome EPPER aqui referido como prurigo pós radioterapia (171).…”

Section: Protocolo De Extração Dos áCidos Nucleicosunclassified

Prurigo pós radioterapia: estudo clínico, histológico e imunohistoquímico

Valle¹

View full text Add to dashboard Cite

Introdução: Prurigo é uma terminologia de conotação sindrômica que tem o prurido como sintoma incondicional. O sinal é dermatológico, caracteristicamente manifestado por pápulas que se distribuem com relativa simetria pelo tegumento. Do ponto de vista clínico é uma condição de fácil suspeita, mas de difícil conclusão causal. Na Fundação Centro de Controle de Oncologia do Amazonas (FCECON), quadro de prurigo em pacientes oncológicos eram ocasionalmente identificados após início da radioterapia para o tratamento do tumor de base, contexto epidemiológico que não é classicamente relacionado ao prurigo. Objetivos: Descrever os aspectos clínicos, histopatológicos e imunoistoquímicos dos casos pósradioterapia. Métodos: estudo transversal, descritivo, de janeiro de 2006 a dezembro de 2012, com seleção de pacientes com CID de prurigo na FCECON. Serão descritas as características clínicas, histopatológicas e imunoistoquimicas dos casos com pesquisa de DNA viral do EBV, CMV e parvovírus B19. Resultados: Foram 35 mulheres e um homem, com idade média de 47 anos, sempre com queixa de prurido. A pelve sempre foi o campo irradiado com mediana de 28 dias para o surgimento dos sintomas. Foram 34 tumores ginecológicos com 31 casos de colo de útero. Ao todo ocorreram 13.339 lesões (média de 371), com 535 do grupo 1 (vesículas e urticas), 4.934 do grupo 2 (pápulas), 4.218 do grupo 3 (escoriações) e 3.652 do grupo 4 (residuais). Os membros inferiores foram acometidos em todos os casos e em 27 casos houve acometimento dos membros superiores. A histologia das 27 lâminas disponíveis identificou epiderme normal em cinco pacientes, atrofia em dois, espongiose em oito e alteração secundária ao prurido nas demais. Espongiose folicular e/ou espongiose do acrossiríngeo foram identificadas por nove ocasiões. Infiltrado perivascular superficial, profundo e intersticial composto por linfócitos e eosinófilos com distribuição perianexial foi o padrão mais encontrado na derme. O padrão do infiltrado foi de linfócitos T CD4 e ausência de linfócitos CD20 e linfócitos CD56. Não foi identificado DNA viral nas amostras examinadas.Discussão: O quadro de prurigo pós-radioterapia possui as mesmas características clínicoepidemiológicas e histológicas da síndrome EPPER. Histologicamente pode ser inclusa dentro das doenças inflamatórias eosinofílicas da pele, com padrão imunoistoquímico do infiltrado sugestivo de reação de hipersensibilidade mediada por linfócitos no padrão Th2. Como reação a picada de mosquitos foi o diagnóstico histológico de todos os casos, postula-se que o prurigo pós radioterapia, ou síndrome EPPER, seja reação imunológica precipitada pela exposição aos antígenos salivares do mosquito em um ambiente imune induzido pelo efeito abscopal secundário a irradiação pélvica. A natureza do estudo não permite confirmar esta conclusão, que deverá ser fruto de pesquisas futuras. Conclusões: O quadro de prurigo pós radioterapia esteve associado a irradiação da pelve, especialmente de tumores ginecológicos, com predomínio do câncer de colo de útero. Cl...

show abstract

Insect bite reaction and HIV infection

Cited by 4 publications

References 4 publications

Folliculocentric lymphocytic hypersensitivity reactions in CLL/SLL patients: A unique clinicopathologic entity amongst non‐specific hypersensitivity reactions

Folliculocentric lymphocytic hypersensitivity reactions in CLL/SLL patients: A unique clinicopathologic entity amongst non‐specific hypersensitivity reactions

Eosinophilic dermatosis of hematologic malignancy: Correlation of molecular characteristics of skin lesions and extracutaneous manifestations of hematologic malignancy

Prurigo pós radioterapia: estudo clínico, histológico e imunohistoquímico

Contact Info

Product

Resources

About