Insect Antifeedant Potent Quinoxalines

Lakshmanan, K.; Sekar, K.; Sathiyendiran, V.; Muthuvel, I.

doi:10.18052/www.scipress.com/ilcpa.41.82

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…Due to their properties, chloro-organic compounds are used in many areas. They are very often applied as antifungal [1,2], antibacterial [3], antifidant [4,5], cytotoxic, and anticancer agents [6]. They are also used as organic solvents, refrigerants and media, dielectrics, pesticides, monomers for the production of plastic materials, and intermediates for organic synthesis [7].…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of Bicyclic Halolactones with a Methyl Group in the Cyclohexane Ring into Hydroxylactones and Their Biological Activity

et al. 2016

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Abstract:The aim of this study was the chemical synthesis of a series of halo-and unsaturated lactones, as well as their microbial transformation products. Finally some of their biological activities were assessed. Three bicyclic halolactones with a methyl group in the cyclohexane ring were obtained from the corresponding γ,δ-unsaturated ester during a two-step synthesis. These lactones were subjected to screening biotransformation using twenty two fungal strains. These strains were tested on their ability to transform halolactones into new hydroxylactones. Among the six strains able to catalyze hydrolytic dehalogenation, only two (Fusarium equiseti, AM22 and Yarrowia lipolytica, AM71) gave a product in a high yield. Moreover, one strain (Penicillium wermiculatum, AM30) introduced the hydroxy group on the cyclohexane ring without removing the halogen atom. The biological activity of five of the obtained lactones was tested. Some of these compounds exhibited growth inhibition against bacteria, yeasts and fungi and deterrent activity against peach-potato aphid.

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