Inorganic Polyphosphate Modulates TRPM8 Channels

Trimm, Harold H.

doi:10.1201/b12873-3

Cited by 5 publications

(33 citation statements)

References 274 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, while inorganic photosynthesis could provide primordial organisms with food, those organisms were unlikely to utilize the electron vacancies generated within mineral crystals. In case of sulfides, the light‐generated vacancies are promptly refilled by sulfide anions yielding elemental sulfur (see Schoonen et al , Mulkidjanian , Mulkidjanian and Galperin , and references therein).…”

Section: Resultsmentioning

confidence: 99%

Emergence of cytochrome bc complexes in the context of photosynthesis

Dibrova

Shalaeva

Galperin

2017

Physiologia Plantarum

View full text Add to dashboard Cite

The cytochrome bc (cyt bc) complexes are involved in Q‐cycling; they oxidize membrane quinols by high‐potential electron acceptors, such as cytochromes or plastocyanin, and generate transmembrane proton gradient. In several prokaryotic lineages, and also in plant chloroplasts, the catalytic core of the cyt bc complexes is built of a four‐helical cytochrome b (cyt b) that contains three hemes, a three‐helical subunit IV, and an iron‐sulfur Rieske protein (cytochrome b 6 f‐type complexes). In other prokaryotic lineages, and also in mitochondria, the cyt b subunit is fused with subunit IV, yielding a seven‐ or eight‐helical cyt b with only two hemes (cyt bc 1‐type complexes). Here we present an updated phylogenomic analysis of the cyt b subunits of cyt bc complexes. This analysis provides further support to our earlier suggestion that (1) the ancestral version of cyt bc complex contained a small four‐helical cyt b with three hemes similar to the plant cytochrome b 6 and (2) independent fusion events led to the formation of large cyts b in several lineages. In the search for a primordial function for the ancestral cyt bc complex, we address the intimate connection between the cyt bc complexes and photosynthesis. Indeed, the Q‐cycle turnover in the cyt bc complexes demands high‐potential electron acceptors. Before the Great Oxygenation Event, the biosphere had been highly reduced, so high‐potential electron acceptors could only be generated upon light‐driven charge separation. It appears that an ancestral cyt bc complex capable of Q‐cycling has emerged in conjunction with the (bacterio)chlorophyll‐based photosynthetic systems that continuously generated electron vacancies at the oxidized (bacterio)chlorophyll molecules.

show abstract

Section: Resultsmentioning

confidence: 99%

Emergence of cytochrome bc complexes in the context of photosynthesis

Dibrova

Shalaeva

Galperin

2017

Physiologia Plantarum

View full text Add to dashboard Cite

show abstract

“…These networks are proposed to have served as the Earth's first biotopes (see the text and the accompanying article [97]). The picture uses data from refs.…”

Section: Discussionmentioning

confidence: 99%

On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth

Mulkidjanian

Galperin

2009

Biol Direct

View full text Add to dashboard Cite

show abstract

“…slowly (Mulkidjanian 2009). On the other hand, Zn can be stripped and remobilized from buried chimney fragments, and concentrated at the seawater interface due to some waterrelated geological activities (Edmond et al 1995).…”

Section: Discussionmentioning

confidence: 99%

“…1979), it has been found that sphalerite (ZnS) and other metal sulphide minerals widespreadly occurred therein. Among these sulphide species, ZnS precipitates occurred more slowly (Mulkidjanian 2009). On the other hand, Zn can be stripped and remobilized from buried chimney fragments, and concentrated at the seawater interface due to some water-related geological activities (Edmond et al .…”

Section: Discussionmentioning

confidence: 99%

Reversible transformation between α-oxo acids and α-amino acids on ZnS particles: a photochemical model for tuning the prebiotic redox homoeostasis

Wang

Liu

Yang

et al. 2012

International Journal of Astrobiology

View full text Add to dashboard Cite

How prebiotic metabolic pathways could have formed is an essential question for the origins of life on early Earth. From the abiogenetic point of view, the emergence of primordial metabolism may be postulated as a continuum from Earth's geochemical processes to chemoautotrophic biochemical procedures on mineral surfaces. In the present study, we examined in detail the reversible amination of α-ketoglutarate on UV-irradiated ZnS particles under variable reaction conditions such as pH, temperature, hole scavenger species and concentrations, and different amino acids. It was observed that the reductive amination of α-ketoglutarate and the oxidative amination of glutamate were both effectively performed on ZnS surfaces in the presence and absence of a hole scavenger, respectively. Accordingly, a photocatalytic mechanism was proposed. The reversible photochemical reaction was more efficient under basic conditions but independent of temperature in the range of 30-60°C. SO 3 2 − was more effective than S 2 − as the hole scavenger. Finally, we extended the glutamate dehydrogenase-like chemistry to a set of other α-amino acids and their corresponding α-oxo acids and found that hydrophobic amino acid side chains were more conducive to the reversible redox reactions. Since the experimental conditions are believed to have been prevalent in shallow water hydrothermal vent systems of early Earth, the results of this work not only suggest that the ZnS-assisted photochemical reaction can regulate the redox equilibrium between α-amino acids and α-oxo acids, but also provide a model of how prebiotic metabolic homoeostasis could have been developed and regulated. These findings can advance our understanding of the establishment of archaic non-enzymatic metabolic systems and the origins of autotrophy.

show abstract

Inorganic Polyphosphate Modulates TRPM8 Channels

Abstract: Background: The complexity of the problem of the origin of life has spawned a large number of possible evolutionary scenarios. Their number, however, can be dramatically reduced by the simultaneous consideration of various bioenergetic, physical, and geological constraints.

Cited by 5 publications

References 274 publications

Emergence of cytochrome bc complexes in the context of photosynthesis

Emergence of cytochrome bc complexes in the context of photosynthesis

On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth

Reversible transformation between α-oxo acids and α-amino acids on ZnS particles: a photochemical model for tuning the prebiotic redox homoeostasis

Contact Info

Product

Resources

About