Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: An animal study

Abstract

Inorganic polyphosphate (poly(P)) is recognized as a therapeutic agent that promotes fibroblast growth factor and enhances osteogenic differentiation, and in vivo, when adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) enhances bone regeneration. The present study focused on the effect of poly(P) adsorbed onto IP-CHA granules (Poly(P)/IP-CHA) in guided bone regeneration (GBR). Dental implants were placed into the edentulous mandibular areas of five Beagle-Labrador hybrid dogs with screw expose on the buccal side, and then bone defects were filled Poly(P)/IP-CHA (test) or IP-CHA (control). After 12 weeks, histological evaluation and histomorphometrical analysis were performed. Newly-bone formation around exposed implant screw was clearly detected in the test-group. The ratio for regenerated bone height in the test group versus the control-group was 85.6±20.2 and 62.6±23.8, respectively, with no significant difference, while, that for bone implant contact was significantly higher (67.9±11.8 and 48.8±14.1, respectively). These findings indicate that Poly(P)/IP-CHA enhances bone regeneration in GBR.

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

“…The enzyme responsible for polyP synthesis in bone tissue cells has not been identified and the signal molecules determining separate stages of this process are unknown. Fascinating, in vivo experiments demonstrated that artificial introduction of polyP into the bone growth or regeneration zone accelerates these processes (Grynpas et al, 2002; Pilliar et al, 2007; Shanjani et al, 2007; Doi et al, 2014). The finding that polyP induces osteoblastic differentiation and bone mineralization creates a basis for development of novel polyP-containing drugs for bone disease treatment and new polyP-containing materials for bone substitution.…”

Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction

“…Porous hydroxyapatite (porous HA, [Ca 10 (PO 4 ) 6 (OH) 2 ]) shows excellent biocompatibility and osteoconduction ability and is used for bone formation at bone defect areas around implants. [1][2][3][4] However, porous HA has insufficient mechanical strength for applications in load-bearing situations or for large bone defects. [5][6][7] In contrast, titanium has been applied in the orthopaedic and dental elds for bone reconstruction or bone graing to x bone plates, articial joints, and dental implants.…”

Influence of Implant Surface Topography on Primary Stability in a Standardized Osteoporosis Rabbit Model Study

“…Glucocorticoids mainly affect bone quality by decreasing bone formation through osteoblastogenesis reduction and increased osteoblast and osteocyte apoptosis. The analysis of various surface modification or novel biomaterials with commercialized dental implant has been performed in healthy animals [ 12 ]. In the future, the significance of these analyses in osteoporotic animal will be demanded in research fields of implant material and biomaterial.…”