Inorganic pharmaceuticals

Moody, LaMaryet; Holder, Alvin A.

doi:10.1039/b716590k

Cited by 3 publications

(2 citation statements)

References 111 publications

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“…Although Ni complexes have been investigated as anticancer agents,72 only a few investigations consider photoactivity;73 for example, [Ni(bpy) 2 (benzo[1.8]naphthyridinone-2-ol)](PF 6 ) 2 binds to DNA in the absence of irradiation, and upon irradiation (λ irr 365 nm) photocleaves the DNA through a mechanism involving both 1 O 2 and HO• radicals 74…”

Section: The Potential Of D-block Metals As Photoactive Anticancer Comentioning

confidence: 99%

Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine

2009

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The fields of phototherapy and of inorganic chemotherapy both have long histories. Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over drug activation and has remarkable potential for the treatment of cancer. Following photoexcitation, a number of different decay pathways (both photophysical and photochemical) are available to a metal complex. These pathways can result in radiative energy release, loss of ligands or transfer of energy to another species, such as triplet oxygen. We discuss the features which need to be considered when developing a metal-based anticancer drug, and the common mechanisms by which the current complexes are believed to operate. We then provide a comprehensive overview of PACT developments for complexes of the different d-block metals for the treatment of cancer, detailing the more established areas concerning Ti, V, Cr, Mn, Re, Fe, Ru, Os, Co, Rh, Pt, and Cu and also highlighting areas where there is potential for greater exploration. Nanoparticles (Ag, Au) and quantum dots (Cd) are also discussed for their photothermal destructive potential. We also discuss the potential held in particular by mixed-metal systems and Ru complexes.

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Section: The Potential Of D-block Metals As Photoactive Anticancer Comentioning

confidence: 99%

Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine

2009

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“…During the last years several studies on palladium compounds described the antiproliferative action of these complexes against tumor cell lines [6][7][8][9][10][11]. Despite its toxicity, arsenic is known as inorganic pharmaceutical [30]. A significant biological activity was observed for As(III) [31], noteworthy are several compounds, which have affinity to protein thiols.…”

Section: Biological Effectsmentioning

confidence: 99%