Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence

Yun, Jong Seok; Pahk, Jung Woon; Lee, Jong Seok; Shin, Wan Seon; Lee, Shin Young; Hong, Eock Kee

doi:10.1007/s10059-011-0256-7

Cited by 23 publications

(8 citation statements)

References 32 publications

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“…Yun et al () reported that I. obliquus extracts ameliorated oxidative stress, inhibited lipid peroxidation, and repressed premature senescence in human fibroblasts by suppressing the activities of MMP‐1 and MMP‐9 and enhancing the production of collagen in in vivo hairless mice. The freeze dried extracts of I. obliquus scavenged DPPH free radicals in a dose‐dependent manner and exhibited a higher superoxide radical scavenging activity when compared with L‐ascorbic acid (Cui et al, ).…”

Section: Influence Of I Obliquus Extract On the Immune Systemmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties. Chemical analysis of this mushroom has allowed the identification of various constituents such as melanins, phenolic compounds, and lanostane-type triterpenoids. A plethora of findings have highlighted the potential molecular mechanisms of actions of this mushroom such as its ability to scavenge reactive oxygen species, inhibit the growth of tumors, decrease inflammation and insulin resistance in type 2 diabetes, and stimulate the immune system. This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action. The possible role of this mushroom as a therapeutic agent in addressing the pathogenesis of diabetes and cancer has also been suggested.

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Section: Influence Of I Obliquus Extract On the Immune Systemmentioning

confidence: 99%

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Duru

Kovaleva

Данилова

et al. 2019

Phytotherapy Research

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“…Numerous studies have tested the effects of solar radiation and oxidative stress on the skin [ 29 , 83 , 84 , 85 ], and oxidative stress has been linked to age-related loss of skin elasticity [ 86 , 87 , 88 ], defective cellular signaling [ 68 ] and photoaging [ 89 , 90 ]. Because it triggers cellular damage pathways, oxidative stress activates cellular senescence which is thought to directly lead to photoaging [ 91 , 92 , 93 , 94 ]. Cellular senescence is associated with a reduced capacity to divide and proliferate, sometimes in conjunction with shortening of telomeres [ 95 , 96 , 97 , 98 ].…”

Section: Oxidative Stress and Agingmentioning

confidence: 99%

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

2014

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Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study long-term effects of aging. Throughout our lifetime, we accumulate damage generated by UV radiation. UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. In this review, we will focus on UV-induced carcinogenesis and photo aging along with natural protective mechanisms that reduce amount of “realized” solar radiation dose and UV-induced injury. We will focus on the theoretical use of forskolin, a plant-derived pharmacologically active compound to protect the skin against UV injury and prevent aging symptoms by up-regulating melanin production. We will discuss its use as a topically-applied root-derived formulation of the Plectranthus barbatus (Coleus forskolii) plant that grows naturally in Asia and that has long been used in various Aryuvedic teas and therapeutic preparations.

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“…For instance, water and ethanolic extracts of chaga protected H 2 O 2 -treated human lymphocyte from DNA damage (Najafzadeh et al, 2007;Park et al, 2005a;Park et al, 2004). Besides, water extracts of chaga also prevented H 2 O 2 -induced apoptosis and premature senescence in human fibroblasts, it functioned through scavenging intracellular ROS (reactive oxygen species), preventing lipid peroxidation, and increasing collagen synthesis through inhibition of MMP-1 and MMP-9 activities (Yun et al, 2011). Recently, Szychowski et al (2018) found that chaga extract enhanced the antioxidative stress ability of normal cells but induced oxidative stress to cancer cells.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Bioactive Compounds and Bioactive Properties of Chaga (Inonotus obliquus) Mushroom: A Review

Peng¹,

Shahidi²

2020

JFB

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Chaga (Inonotus obliquus) is an edible herbal mushroom extensively distributed in the temperate to frigid regions of the Northern hemisphere, especially the Baltic and Siberian areas. Chaga parasites itself on the trunk of various angiosperms, especially birch tree, for decades and grows to be a shapeless black mass. The medicinal/nutraceutical use of chaga mushroom has been recorded in different ancient cultures of Ainu, Khanty, First Nations, and other Indigenous populations. To date, due to its prevalent use as folk medicine/functional food, a plethora of studies on bioactive compounds and corresponding compositional analysis has been conducted in the past 20 years. In this contribution, various nutraceutical and pharmaceutical potential, including antioxidant, anti-inflammatory, anti-tumor, immunomodulatory, antimutagenic activity, anti-virus, analgesic, antibacterial, antifungal, anti-hyperglycemic, and anti-hyperuricemia activities/effects, as well as main bioactive compounds including phenolics, terpenoids, polysaccharides, fatty acids, and alkaloids of chaga mushroom have been thoroughly reviewed, and tabulated using a total 171 original articles. However, only key bioactivities and bioactives are selectively discussed. Besides, the up-to-date toxicity concerns and risk assessment about the misuse of chaga, which limit its acceptance and use as medicinal/nutraceutical products, have also been clarified.

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Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence

Cited by 23 publications

References 32 publications

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

Bioactive Compounds and Bioactive Properties of Chaga (Inonotus obliquus) Mushroom: A Review

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