Innovative Use of 13С-methacetin Breathing Test to Assess the Rate of Hepatic Fibrosis

Medvedev, Yu. V.; Бакулин, И. Г.; Nemtsova, E.G.; Sayganov, S. A.; Бакулина, Н. В.

doi:10.31550/1727-2378-2019-163-8-6-12

Cited by 2 publications

(1 citation statement)

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“…Поскольку специфического противовирусного лечения для SARS-CoV-2 не существует, в соответствии с Временными методическими рекомендациями Минздрава России [10] используют различные жаропонижающие, противовирусные, антибактериальные препараты, биологическую терапию и глюкокортикоиды, каждый из которых или их комбинация может привести к лекарственному повреждению печени и, в первую очередь, это относится к антибактериальным и нестероидным противовоспалительным препаратам. Кроме того, лекарственное взаимодействие нескольких препаратов, принимаемых одновременно для лечения COVID-19, может увеличить риск поражения печени.…”

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New coronavirus infection and liver lesions

Prokofieva

Бакулин

Nemtsova

et al. 2023

Russian Family Doctor

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BACKGROUND: According to published research outcomes, liver dysfunction is one of the predictors of adverse outcome COVID-19. AIM: To study the frequency and severity of liver damage in COVID-19 and suggest therapeutic and prevention approaches to liver damage. MATERIALS AND METHODS: The study included 171 patients with SARS-CoV-2 pneumonia at the age of 2194 (mean age 59.85 14.96). Clinical and biochemical blood tests, coagulogram, blood ammonia test, number linkage test, multislice computed tomography of the chest, and 13C-metacetin breath test. Patients were divided into two groups depending on the volume of lung injury. Statistical processing of the results was performed with the software SPSS 26. RESULTS: The most frequent symptoms were manifestations of intoxication syndrome, respiratory failure, the severity of which correlated with the volume of lung tissue damage according to multislice computed tomography of the chest. In both groups, the activity of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltranspeptidase, and alkaline phosphate increased. However, significant distinctions in the groups were revealed only for gamma-glutamyltranspeptidase and alkaline phosphate levels. The level of C-reactive protein in both groups directly correlated with the level of cytolysis and cholestasis, indicating a significant role of the liver in pathological processes in COVID-19. Conclusion: Hyperammonemia and decreased liver functional reserve of various severity were observed in all patients. CONCLUSIONS: The findings indicate the diagnostic value of the studied parameters for the evaluation of liver damage, as well as the applications of prevention and treatment measures for liver lesions in patients with COVID-19.

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Section: обоснованиеunclassified

New coronavirus infection and liver lesions

Prokofieva

Бакулин

Nemtsova

et al. 2023

Russian Family Doctor

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Clearance tests as a diagnosis method of hepatobiliary system pathologies in animals

Ponamarev,

Popova,

Kostrova

et al. 2023

Аграрная наука Евро-Северо-Востока

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In present-day conditions of industrial agriculture, the animal's body works at the limit of its capabilities, which leads to degenerative diseases of various organs and systems. The development of ergonomic ways of modern diagnosis of these pathologies at the early stages contributes to the maintenance of quantitative and qualitative indices of productivity of animals and to the extension of the time of their economic use. The liver with a great number of functions performed is subjected to the highest load. The aim of the article is to review the available clearance tests in order to diagnose the pathology of the hepatobiliary system of animals at the early stage, considering advantages and disadvantages of the tests. As the result of the search of themed issues in various bibliographic databases there have been selected 45 mostly cited scientific articles. The article reviews such clearance tests as indocyanine green clearance test, aminopyrine breath test, sorbitol elimination test, galactose elimination test, phenylalanine breath test, and hepatobiliary scintigraphy method. Functional tests allow not only diagnosing and differentiating hepatopathologies, but also visualizing their course and liver recovery. Unlike laboratory tests, clearance tests make it possible to evaluate the work of the liver in dynamics. The disadvantages of clearance tests are lack of information for their wide use and frequency of particular differences in elimination of specific substances. To reduce the proportion of existing shortcomings, it is possible to combine clearance tests with other laboratory methods for diagnosing hepatopathy in animals.

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Innovative Use of 13С-methacetin Breathing Test to Assess the Rate of Hepatic Fibrosis

Cited by 2 publications

References 0 publications

New coronavirus infection and liver lesions

New coronavirus infection and liver lesions

Clearance tests as a diagnosis method of hepatobiliary system pathologies in animals

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