Innovative intragastric ascaridole floating tablets: Development, optimization, and in vitro–in vivo evaluation

Zhao, Qiang; Gao, Baoan; Ma, Lulu; Lian, Jianhao; Deng, Li; Chen, Jianming

doi:10.1016/j.ijpharm.2015.10.007

Cited by 29 publications

(6 citation statements)

References 29 publications

(25 reference statements)

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“…To investigate the possible release mechanism of cefditoren from floating matrices, the release results were mathematically analyzed according to the zero-order, first-order, and Higuchi model (Korsmeyer et al, 1983;Liu and Fassihi, 2008;Siber et al, 2005;Tadros, 2010;Zhao et al, 2015). The most appropriate model was selected according to the correlation values (r).…”

Section: Kinetic Analysis Of the Release Datamentioning

confidence: 99%

Gastroretentive floating matrix tablets of cefditoren pivoxil: 23 full factorial design, formulation, in vitro evaluation, and optimization

El-Masry¹,

M.²,

Habib³

2022

J App Pharm Sci

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Cefditoren pivoxil is a bactericidal cephalosporin with low oral bioavailability and short half-life. It is used twice daily, causing patient inconvenience and plasma concentration fluctuations. The present work aimed to design a gastroretentive floating matrix of cefditoren pivoxil after enhancing its solubility by solid dispersion technique. Cefditoren solid dispersions (SDs) were prepared by utilizing polyvinylpyrrolidone (PVP) and poloxamer 188. The resulting SDs enhanced cefditoren pivoxil dissolution rate compared to PM; this may be due to the change in physical properties of drug crystal which is confirmed by thermal analysis. SD prepared by PVP was selected for further consideration to prepare gastro-retentive retentive tablets (GFTs) . 2 3 full factorial designs with eight formulations were prepared to utilize the direct compression method. Hydrophilic or hydrophobic swellable polymers (hydroxypropyl methylcellulose K15M or ethyl acetate, respectively) were used with or without a gas-generating agent such as citric acid and sodium bicarbonate. Precompression and postcompression assessments were carried out for powder mixture and GFTs, respectively. F3 displayed the best-sustained release profile. Furthermore, F3 showed good physical stability upon storage under accelerated conditions (40 o C/75% RH) for 3 months.

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Section: Kinetic Analysis Of the Release Datamentioning

confidence: 99%

Gastroretentive floating matrix tablets of cefditoren pivoxil: 23 full factorial design, formulation, in vitro evaluation, and optimization

El-Masry¹,

M.²,

Habib³

2022

J App Pharm Sci

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“…The floating beads were structurally hollow spheres with a bulk density of <1 g/ml and a porosity of 34%. An in vivo study on rabbits was performed by gamma scintigraphy showing gastroretention of beads up to 5 h. There have been several other recent reports of success in vivo gastric retention of floating tablets and microspheres containing versatile drug molecules such as ascaridole, calcium-disodium edentate, and repaglinide [76,77]. Magnetic resonance imaging is another technique to prove in vivo gastroretention of a GRDDS.…”

Section: In Vivo Assessment Of Gastroretentive Propertiesmentioning

confidence: 99%

In Vitro in Vivo Studies on Floating Microspheres for Gastroretentive Drug Delivery System: A Review

Krishna¹,

Kumar

Rajat

2021

Asian J Pharm Clin Res

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The purpose of writing this review on gastroretentive drug delivery systems (GRDDS) was to compile the recent literature with a special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. One of the complex processes in the human body is gastric emptying, as it is highly variable, which makes the in vivo performance of the drug delivery systems uncertain. GRDDS has gained immense popularity in the field of oral drug delivery recently. It is a widely employed approach to retain the dosage form in the stomach for an extended period of time and release the drug slowly that can address many challenges associated with the conventional oral delivery system. Conventional drug delivery systems may not overcome the issues imposed by the gastrointestinal tract (GIT) such as incomplete release of drugs, decrease in dose effectiveness, and frequent dose requirement. To overcome this variability, a controlled drug delivery system with a prolonged gastric residence time of >12 h in the stomach can be of great practical importance for drugs with an absorption window in the upper small intestine. GRDFs enable prolonged and continuous release of the drug to the upper part of the GIT and thus significantly extend the duration of drug release and improve the bioavailability of drugs that have a narrow therapeutic window; by this way, they prolong dosing interval and increase compliance.

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“…Direct compression techniques were used for the preparation of the tablets whereas content uniformity, friability, weight variation and hardness parameter were taken for their evaluation. Further, drug release behaviors, total floating time, floating lag time were also evaluated during the study [48].…”

Section: Analytical Aspect Of Ascaridolementioning

confidence: 99%

A phytochemical of modern medicinal perspective

Patel¹

2017

JCLM

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Innovative intragastric ascaridole floating tablets: Development, optimization, and in vitro–in vivo evaluation

Cited by 29 publications

References 29 publications

Gastroretentive floating matrix tablets of cefditoren pivoxil: 23 full factorial design, formulation, in vitro evaluation, and optimization

Gastroretentive floating matrix tablets of cefditoren pivoxil: 23 full factorial design, formulation, in vitro evaluation, and optimization

In Vitro in Vivo Studies on Floating Microspheres for Gastroretentive Drug Delivery System: A Review

A phytochemical of modern medicinal perspective

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