Innovations in thoracic imaging: <scp>CT</scp>, radiomics, <scp>AI</scp> and x‐ray velocimetry

Vliegenthart, Rozemarijn; Fouras, Andreas; Jacobs, Colin; Papanikolaou, Nikolaos

doi:10.1111/resp.14344

Cited by 24 publications

(18 citation statements)

References 117 publications

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“…Balancing the positive impact of LCS on LC mortality with the risks of radiation exposure is one major focus of LCS literature. Recent improvements in CT hardware and software fostered a great interest in reducing the radiation burden beyond the current state-of-the-art in thoracic imaging (LDCT) toward imaging at a calculated radiation dose of below 1 milliSievert, termed ultra-low-dose CT (ULDCT) [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Study rationale and design of the PEOPLHE trial

Milanese,

Silva,

Ledda

et al. 2024

Radiol med

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Purpose Lung cancer screening (LCS) by low-dose computed tomography (LDCT) demonstrated a 20–40% reduction in lung cancer mortality. National stakeholders and international scientific societies are increasingly endorsing LCS programs, but translating their benefits into practice is rather challenging. The “Model for Optimized Implementation of Early Lung Cancer Detection: Prospective Evaluation Of Preventive Lung HEalth” (PEOPLHE) is an Italian multicentric LCS program aiming at testing LCS feasibility and implementation within the national healthcare system. PEOPLHE is intended to assess (i) strategies to optimize LCS workflow, (ii) radiological quality assurance, and (iii) the need for dedicated resources, including smoking cessation facilities. Methods PEOPLHE aims to recruit 1.500 high-risk individuals across three tertiary general hospitals in three different Italian regions that provide comprehensive services to large populations to explore geographic, demographic, and socioeconomic diversities. Screening by LDCT will target current or former (quitting < 10 years) smokers (> 15 cigarettes/day for > 25 years, or > 10 cigarettes/day for > 30 years) aged 50–75 years. Lung nodules will be volumetric measured and classified by a modified PEOPLHE Lung-RADS 1.1 system. Current smokers will be offered smoking cessation support. Conclusion The PEOPLHE program will provide information on strategies for screening enrollment and smoking cessation interventions; administrative, organizational, and radiological needs for performing a state-of-the-art LCS; collateral and incidental findings (both pulmonary and extrapulmonary), contributing to the LCS implementation within national healthcare systems.

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Section: Discussionmentioning

confidence: 99%

Study rationale and design of the PEOPLHE trial

Milanese,

Silva,

Ledda

et al. 2024

Radiol med

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“…Bei rein pulmonaler Fragestellung ist die CT auch im Niedrigstrahlendosisbereich ohne Kontrastmittel möglich. Unterstützend werden Bildnachbearbeitungen angewendet, wie multiplanare Rekonstruktionen, Maximum-Intensitäts-Projektionen, CAD(„computer aided diagnosis“)-Systeme und Texturanalysen mit zunehmender Unterstützung durch künstliche Intelligenz [ 4 ].…”

Section: Bildgestützte Diagnostik Und Therapieunclassified

Lungenmetastasen – Onkologische Bedeutung und Therapie

Krämer¹,

Bläker²,

Denecke³

et al. 2023

best practice onkologie

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Hintergrund Die Lunge ist ein häufiger Ort der Metastasierung bei einer Vielzahl unterschiedlicher Tumorerkrankungen. Fragestellung Darstellung der Inzidenz, Diagnostik, Therapie und Prognose von Lungenmetastasen. Material und Methode Sichtung der relevanten Literatur über öffentlich zugängliche Datenbanken (u. a. PubMed, Embase) und Bewertung im multidisziplinären Expertenkreis Ergebnisse Die Lungenmetastasierung bedarf einer differenzierten und spezialisierten radiologischen und histopathologischen Bewertung. Es stehen zahlreiche wirksame lokal-ablative und systemische Behandlungsverfahren zur Verfügung. Schlussfolgerung Der Beitrag gibt eine multidisziplinäre ausgerichtete Übersicht über Diagnose- und Therapieoptionen bei Lungenmetastasen

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“… Examples of radiographically derived ventilation. Panel (A) shows XV analysis of regional lung ventilation using a color scale (red represents areas with decreased ventilation) ( 31 ). Panel (B) represents 4D CT imaging which shows regional areas of high ventilation and areas of low ventilation (red represents areas with decreased ventilation).…”

Section: Introductionmentioning

confidence: 99%

Functional imaging for assessing regional lung ventilation in preclinical and clinical research

Karmali

Sowho²,

Bose

et al. 2023

Front. Med.

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Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized to assess lung function, they do not provide adequate information on regional ventilatory distribution nor function assessments of ventilation during the respiratory cycle. Emerging technologies such as xenon CT, volumetric CT, functional MRI and X-ray velocimetry can assess regional ventilation using non-invasive radiographic methods that may complement current methods of assessing lung function. As a supplement to current modalities of pulmonary function assessment, functional lung imaging has the potential to identify respiratory disease phenotypes with distinct natural histories. Moreover, these novel technologies may offer an optimal strategy to evaluate the effectiveness of novel therapies and therapies targeting localized small airways disease in preclinical and clinical research. In this review, we aim to discuss the features of functional lung imaging, as well as its potential application and limitations to adoption in research.

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Innovations in thoracic imaging: CT, radiomics, AI and x‐ray velocimetry

Cited by 24 publications

References 117 publications

Study rationale and design of the PEOPLHE trial

Study rationale and design of the PEOPLHE trial

Lungenmetastasen – Onkologische Bedeutung und Therapie

Functional imaging for assessing regional lung ventilation in preclinical and clinical research

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